Skip to main content

Research Repository

Advanced Search

Analysis of the interaction and proliferative activity of adenocarcinoma, peripheral blood mononuclear and mesenchymal stromal cells after co-cultivation in vitro

Kitaeva, Kristina V.; Prudnikov, Tikhon S.; Gomzikova, Marina O.; Kletukhina, Sevindzh K.; James, Victoria; Rizvanov, Albert A.; Solovyeva, Valeriya V.

Authors

Kristina V. Kitaeva

Tikhon S. Prudnikov

Marina O. Gomzikova

Sevindzh K. Kletukhina

Victoria James

Albert A. Rizvanov

Valeriya V. Solovyeva



Abstract

The tumor microenvironment is a heterogeneous population of cells actively involved in the process of growth and development of a tumor. Research has demonstrated the interactions between the different populations of cells are critical for the formation of the tumor microenvironment and, if recapitulated experimentally, can be used to produce more effective models for preclinical screening of anticancer drugs. In this study, we demonstrate co-culturing HeLa adenocarcinoma cells, peripheral blood mononuclear cells, and mesenchymal stromal cells results in changes in the proliferative activity of the peripheral blood mononuclear cells and mesenchymal stromal cell populations. This data supports the further development of in vitro co-culture systems utilizing these cell types for pre-clinical screening of anticancer drugs.

Journal Article Type Article
Publication Date Mar 15, 2019
Journal BioNanoScience
Print ISSN 2191-1630
Electronic ISSN 2191-1649
Publisher Humana Press
Peer Reviewed Peer Reviewed
APA6 Citation Kitaeva, K. V., Prudnikov, T. S., Gomzikova, M. O., Kletukhina, S. K., James, V., Rizvanov, A. A., & Solovyeva, V. V. (2019). Analysis of the interaction and proliferative activity of adenocarcinoma, peripheral blood mononuclear and mesenchymal stromal cells after co-cultivation in vitro. BioNanoScience, doi:10.1007/s12668-019-00625-z
DOI https://doi.org/10.1007/s12668-019-00625-z
Keywords Co-culture; Intercellular interaction; Adenocarcinoma; Mononuclear blood cell; Mesenchymal stromal cell; Test system; Drug screening
Publisher URL https://link.springer.com/article/10.1007/s12668-019-00625-z

Files

Analysis of the interaction and proliferative activity of adenocarcinoma, peripheral blood mononuclear and mesenchymal stromal cells after co-cultivation in vitro (1.1 Mb)
PDF





You might also like



Downloadable Citations

;