SnoRNAs in cardiovascular development, function, and disease

Chabronova, Alzbeta; Holmes, Terri L.; Hoang, Duc M.; Denning, Chris; James, Victoria; Smith, James G. W.; Peffers, Mandy J.

Abstract

Small nucleolar RNAs (snoRNAs) are emerging as important regulators of cardiovascular (patho)biology. Several roles of snoRNAs have recently been identified in heart development and congenital heart diseases, as well as their dynamic regulation in hypertrophic and dilated cardiomyopathies, coronary heart disease (CHD), myocardial infarction (MI), cardiac fibrosis, and heart failure. Furthermore, reports of changes in vesicular snoRNA expression and altered levels of circulating snoRNAs in response to cardiac stress suggest that snoRNAs also function in cardiac signaling and intercellular communication. In this review, we summarize and discuss key findings and outline the clinical potential of snoRNAs considering current challenges and gaps in the field of cardiovascular diseases (CVDs).

Citation

Chabronova, A., Holmes, T. L., Hoang, D. M., Denning, C., James, V., Smith, J. G. W., & Peffers, M. J. (2024). SnoRNAs in cardiovascular development, function, and disease. Trends in Molecular Medicine, 30(6), 562-578. https://doi.org/10.1016/j.molmed.2024.03.004

• Journal Article Type: Review
• Acceptance Date: Mar 8, 2024
• Online Publication Date: Mar 23, 2024
• Publication Date: 2024-06
• Deposit Date: May 25, 2024
• Publicly Available Date: May 28, 2024
• Journal: Trends in Molecular Medicine
• Print ISSN: 1471-4914
• Electronic ISSN: 1471-499X
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 30
• Issue: 6
• Pages: 562-578
• DOI: https://doi.org/10.1016/j.molmed.2024.03.004
• Keywords: extracellular vesicles, snoRNA, cardiomyopathy, exercise, biomarker, cardiac fibrosis
• Public URL: https://nottingham-repository.worktribe.com/output/33549029
• Publisher URL: https://www.cell.com/trends/molecular-medicine/fulltext/S1471-4914(24)00059-5