Therapeutic Potential of Extracellular Vesicles for the Treatment of Nerve Disorders

Galieva, Luisa R.; James, Victoria; Mukhamedshina, Yana O.; Rizvanov, Albert A.

doi:10.3389/fnins.2019.00163

Authors

Luisa R. Galieva

VICTORIA JAMES Victoria.James@nottingham.ac.uk
Associate Professor

Yana O. Mukhamedshina

Albert A. Rizvanov

Abstract

The use of extracellular vesicles (EVs) as cell free therapy is a promising approach to stimulate tissue regeneration including that of the nervous system. EVs transfer bioactive proteins and lipids, RNA and microRNAs, which play a relevant role in EV-mediated intercellular communication. The immunomodulatory, anti-inflammatory, and neuroprotective effects of mesenchymal stem cells-derived EVs have been well studied, knowledge of this paracrine mechanism and the availability of these cells, positions mesenchymal stem cells as a potential source of EVs for cell free therapy for a variety of regenerative and nervous system disorders. In this review, we focus on the immunomodulatory and neuroprotective effects of stem cells-derived EVs within in vitro and in vivo models of nerve disorders.

Citation

Galieva, L. R., James, V., Mukhamedshina, Y. O., & Rizvanov, A. A. (2019). Therapeutic Potential of Extracellular Vesicles for the Treatment of Nerve Disorders. Frontiers in Neuroscience, 13, https://doi.org/10.3389/fnins.2019.00163

Journal Article Type	Article
Acceptance Date	Feb 12, 2019
Online Publication Date	Mar 5, 2019
Publication Date	Mar 5, 2019
Deposit Date	Mar 5, 2019
Publicly Available Date	Mar 5, 2019
Journal	Frontiers in Neuroscience
Print ISSN	1662-4548
Publisher	Frontiers Media
Peer Reviewed	Peer Reviewed
Volume	13
Article Number	163
DOI	https://doi.org/10.3389/fnins.2019.00163
Public URL	https://nottingham-repository.worktribe.com/output/1610104
Publisher URL	https://www.frontiersin.org/articles/10.3389/fnins.2019.00163/full