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Therapeutic Potential of Extracellular Vesicles for the Treatment of Nerve Disorders

Galieva, Luisa R.; James, Victoria; Mukhamedshina, Yana O.; Rizvanov, Albert A.

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Authors

Luisa R. Galieva

Yana O. Mukhamedshina

Albert A. Rizvanov



Abstract

The use of extracellular vesicles (EVs) as cell free therapy is a promising approach to stimulate tissue regeneration including that of the nervous system. EVs transfer bioactive proteins and lipids, RNA and microRNAs, which play a relevant role in EV-mediated intercellular communication. The immunomodulatory, anti-inflammatory, and neuroprotective effects of mesenchymal stem cells-derived EVs have been well studied, knowledge of this paracrine mechanism and the availability of these cells, positions mesenchymal stem cells as a potential source of EVs for cell free therapy for a variety of regenerative and nervous system disorders. In this review, we focus on the immunomodulatory and neuroprotective effects of stem cells-derived EVs within in vitro and in vivo models of nerve disorders.

Journal Article Type Article
Acceptance Date Feb 12, 2019
Online Publication Date Mar 5, 2019
Publication Date Mar 5, 2019
Deposit Date Mar 5, 2019
Publicly Available Date Mar 5, 2019
Journal Frontiers in Neuroscience
Print ISSN 1662-4548
Publisher Frontiers Media
Peer Reviewed Peer Reviewed
Volume 13
Article Number 163
DOI https://doi.org/10.3389/fnins.2019.00163
Public URL https://nottingham-repository.worktribe.com/output/1610104
Publisher URL https://www.frontiersin.org/articles/10.3389/fnins.2019.00163/full

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