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All Outputs (960)

Maternal depression, antidepressant prescriptions, and congenital anomaly risk in offspring: a population-based cohort study (2014)
Journal Article
Ban, L., Gibson, J. E., West, J., Fiaschi, L., Sokal, R., Smeeth, L., …Tata, L. J. (in press). Maternal depression, antidepressant prescriptions, and congenital anomaly risk in offspring: a population-based cohort study. BJOG: An International Journal of Obstetrics and Gynaecology, 121(12), https://doi.org/10.1111/1471-0528.12682

OBJECTIVE: To estimate risks of major congenital anomaly (MCA) among children of mothers prescribed antidepressants during early pregnancy or diagnosed with depression but without antidepressant prescriptions. DESIGN: Population-based cohort study.... Read More about Maternal depression, antidepressant prescriptions, and congenital anomaly risk in offspring: a population-based cohort study.

Venous thromboembolism in children with cancer – a population-based cohort study (2014)
Journal Article
Walker, A. J., Grainge, M. J., Card, T. R., West, J., Ranta, S., & Ludvigsson, J. F. (2014). Venous thromboembolism in children with cancer – a population-based cohort study. Thrombosis Research, 133(3), https://doi.org/10.1016/j.thromres.2013.12.021

Introduction: Cancer is a known risk factor for venous thromboembolism (VTE) in adults, but population-based data in children are scarce. Materials and methods: We conducted a cohort study utilising linkage of the Clinical Practice Research Datab... Read More about Venous thromboembolism in children with cancer – a population-based cohort study.

Variation in the risk of venous thromboembolism in people with colorectal cancer: a population-based cohort study from England (2014)
Journal Article
Walker, A., West, J., Card, T. R., Humes, D., & Grainge, M. J. (2014). Variation in the risk of venous thromboembolism in people with colorectal cancer: a population-based cohort study from England. Journal of Thrombosis and Haemostasis, 12(5), https://doi.org/10.1111/jth.12533

BACKGROUND: Patients with colorectal cancer are at high risk of developing venous thromboembolism (VTE), and recent international guidelines have advised extended prophylaxis for some of these patients following surgery or during chemotherapy. Howeve... Read More about Variation in the risk of venous thromboembolism in people with colorectal cancer: a population-based cohort study from England.

Small-Cell Lung Cancer in England: Trends in Survival and Chemotherapy Using the National Lung Cancer Audit (2014)
Journal Article
Khakwani, A., Rich, A. L., Tata, L. J., Powell, H. A., Stanley, R. A., Baldwin, D. R., & Hubbard, R. B. (2014). Small-Cell Lung Cancer in England: Trends in Survival and Chemotherapy Using the National Lung Cancer Audit. PLoS ONE, 9(2), Article e89426. https://doi.org/10.1371/journal.pone.0089426

Background The purpose of this study was to identify trends in survival and chemotherapy use for individuals with small-cell lung cancer (SCLC) in England using the National Lung Cancer Audit (NLCA). Methods We used data from the NLCA database... Read More about Small-Cell Lung Cancer in England: Trends in Survival and Chemotherapy Using the National Lung Cancer Audit.

Signalling Paediatric Side Effects using an Ensemble of Simple Study Designs (2014)
Journal Article
Reps, J., M. Garibaldi, J., Aickelin, U., Soria, D., E. Gibson, J., & B. Hubbard, R. (2014). Signalling Paediatric Side Effects using an Ensemble of Simple Study Designs. Drug Safety, 37(3), 163-170. https://doi.org/10.1007/s40264-014-0137-z

Background: Children are frequently prescribed medication `o-label', meaning there has not been sucient testing of the medication to determine its safety or eectiveness. The main reason this safety knowledge is lacking is due to ethical restrictions... Read More about Signalling Paediatric Side Effects using an Ensemble of Simple Study Designs.

The epidemiology of irritable bowel syndrome (2014)
Journal Article
Canavan, C., West, J., & Card, T. R. (2014). The epidemiology of irritable bowel syndrome. Clinical Epidemiology, 6, https://doi.org/10.2147/CLEP.S40245

Irritable bowel syndrome (IBS) is a functional condition of the bowel that is diagnosed using clinical criteria. This paper discusses the nature of the diagnostic process for IBS and how this impacts epidemiological measurements. Depending on the dia... Read More about The epidemiology of irritable bowel syndrome.

Smoking cessation advice recorded during pregnancy in United Kingdom primary care (2014)
Journal Article
Hardy, B., Szatkowski, L., Tata, L. J., Coleman, T., & Dhalwani, N. (2014). Smoking cessation advice recorded during pregnancy in United Kingdom primary care. BMC Family Practice, 15(21), https://doi.org/10.1186/1471-2296-15-21

Background: United Kingdom (UK) national guidelines recommend that all pregnant women who smoke should be advised to quit at every available opportunity, and brief cessation advice is an efficient and cost-effective means to increase quit rates. The... Read More about Smoking cessation advice recorded during pregnancy in United Kingdom primary care.

1 and 5 year survival estimates for people with cirrhosis of the liver in England, 1998–2009: a large population study (2014)
Journal Article
Ratib, S., Fleming, K. M., Crooks, C. J., Aithal, G. P., & West, J. (2014). 1 and 5 year survival estimates for people with cirrhosis of the liver in England, 1998–2009: a large population study. Journal of Hepatology, 60(2), https://doi.org/10.1016/j.jhep.2013.09.027

BACKGROUND & AIMS: Large, population-based studies that have included the full spectrum of cirrhosis estimating survival, taking into account time-at-risk are lacking. We aimed to report 1- and 5-year average survival rates for people with cirrhosis... Read More about 1 and 5 year survival estimates for people with cirrhosis of the liver in England, 1998–2009: a large population study.

Occurrence of liver cirrhosis in England, a cohort study, 1998-2009: a comparison with cancer (2014)
Journal Article
Ratib, S., West, J., Crooks, C. J., & Fleming, K. M. (2014). Occurrence of liver cirrhosis in England, a cohort study, 1998-2009: a comparison with cancer. American Journal of Gastroenterology, 109(2), https://doi.org/10.1038/ajg.2013.405

OBJECTIVES: There is no routine registration of the occurrence of newly diagnosed cases of cirrhosis in the United Kingdom. This study seeks to determine precise estimates and trends of the incidence of cirrhosis in England, and directly compare the... Read More about Occurrence of liver cirrhosis in England, a cohort study, 1998-2009: a comparison with cancer.

Patients' and healthcare professionals' views on a specialist smoking cessation service delivered in a United Kingdom hospital: a qualitative study (2014)
Journal Article
Bains, M., Britton, J., Marsh, J., Jayes, L., & Murray, R. L. (2014). Patients' and healthcare professionals' views on a specialist smoking cessation service delivered in a United Kingdom hospital: a qualitative study. Tobacco Induced Diseases, 12(2), https://doi.org/10.1186/1617-9625-12-2

BACKGROUND: Hospital admission provides a powerful opportunity to promote smoking cessation. We explored patients' and healthcare professionals' (HCP) views of a specialist smoking cessation service comprising systematic smoking ascertainment, defau... Read More about Patients' and healthcare professionals' views on a specialist smoking cessation service delivered in a United Kingdom hospital: a qualitative study.

Rising burden of gout in the UK but continuing suboptimal management: A nationwide population study (2014)
Journal Article
Kuo, C. F., Grainge, M. J., Mallen, C., Zhang, W., & Doherty, M. (2015). Rising burden of gout in the UK but continuing suboptimal management: A nationwide population study. Annals of the Rheumatic Diseases, 74(4), 661-667. https://doi.org/10.1136/annrheumdis-2013-204463

Objectives: To describe trends in the epidemiology of gout and patterns of urate-lowering treatment (ULT) in the UK general population from 1997 to 2012. Methods: We used the Clinical Practice Research Datalink to estimate the prevalence and incidenc... Read More about Rising burden of gout in the UK but continuing suboptimal management: A nationwide population study.

Rate of improvement of CF life expectancy exceeds that of general population: observational death registration study (2014)
Journal Article
Hurley, M., McKeever, T. M., Prayle, A. P., Smyth, A. R., & Fogarty, A. W. (2014). Rate of improvement of CF life expectancy exceeds that of general population: observational death registration study. Journal of Cystic Fibrosis, 13(4), https://doi.org/10.1016/j.jcf.2013.12.002

Background: It is unclear why cystic fibrosis (CF) survival has improved. We wished to quantify increases in CF median age of death in the context of general population survival improvement. Method: Death registration data analysis (US, England & Wa... Read More about Rate of improvement of CF life expectancy exceeds that of general population: observational death registration study.

The direct medical costs of epilepsy in children and young people: a population-based study of health resource utilisation (2014)
Journal Article
Ali, M. A. S., Elliott, R. A., & Tata, L. J. (in press). The direct medical costs of epilepsy in children and young people: a population-based study of health resource utilisation. Epilepsy Research, 108(3), https://doi.org/10.1016/j.eplepsyres.2013.12.014

We described the health resource utilisation (HRU) and associated direct medical costs of managing epilepsy in children and young people (CYP) using population-level data from the United Kingdom. The study cohort were CYP born between 1988 and 20... Read More about The direct medical costs of epilepsy in children and young people: a population-based study of health resource utilisation.

Treatment decisions and survival for people with small-cell lung cancer (2014)
Journal Article
Powell, H., Tata, L., Baldwin, D., Potter, V., Stanley, R., Khakwani, A., & Hubbard, R. (in press). Treatment decisions and survival for people with small-cell lung cancer. British Journal of Cancer, 110(4), https://doi.org/10.1038/bjc.2013.812

Background: Chemotherapy improves survival for many patients with SCLC, and hence it is important to understand variations in practice and outcomes for this treatment strategy. Methods: We used the National Lung Cancer Audit and Hospital Episodes... Read More about Treatment decisions and survival for people with small-cell lung cancer.

Copy Number Variation of the Beta-Defensin Genes in Europeans: No Supporting Evidence for Association with Lung Function, Chronic Obstructive Pulmonary Disease or Asthma (2014)
Journal Article
Wain, L. V., Odenthal-Hesse, L., Abujaber, R., Sayers, I., Beardsmore, C., Gaillard, E. A., …Hollox, E. J. (2014). Copy Number Variation of the Beta-Defensin Genes in Europeans: No Supporting Evidence for Association with Lung Function, Chronic Obstructive Pulmonary Disease or Asthma. PLoS ONE, 9(1), Article e84192. https://doi.org/10.1371/journal.pone.0084192

Lung function measures are heritable, predict mortality and are relevant in diagnosis of chronic obstructive pulmonary disease (COPD). COPD and asthma are diseases of the airways with major public health impacts and each have a heritable component. G... Read More about Copy Number Variation of the Beta-Defensin Genes in Europeans: No Supporting Evidence for Association with Lung Function, Chronic Obstructive Pulmonary Disease or Asthma.

Health status of UK care home residents: a cohort study (2014)
Journal Article
Gordon, A. L., Franklin, M., Bradshaw, L., Logan, P., Elliott, R., & Gladman, J. R. (2014). Health status of UK care home residents: a cohort study. Age and Ageing, 43(1), https://doi.org/10.1093/ageing/aft077

Background: UK care home residents are often poorly served by existing healthcare arrangements. Published descriptions of residents’ health status have been limited by lack of detail and use of data derived from surveys drawn from social, rather than... Read More about Health status of UK care home residents: a cohort study.

Did hardening occur among smokers in England from 2000 to 2010? (2014)
Journal Article
Docherty, G., McNeill, A., Gartner, C., & Szatkowski, L. (2014). Did hardening occur among smokers in England from 2000 to 2010?. Addiction, 109(1), https://doi.org/10.1111/add.12359

Aims To assess trends in the prevalence of ‘hardcore’ smoking in England between 2000 and 2010, and to examine associations between hardcore smoking and socio-demographic variables. Design Secondary analysis of data from the United Kingdom's... Read More about Did hardening occur among smokers in England from 2000 to 2010?.

Perinatal maternal life events and psychotic experiences in children at twelve years in a birth cohort study (2013)
Journal Article
Dorrington, S., Zammit, S., Asher, L., Evans, J., Heron, J., & Lewis, G. (2014). Perinatal maternal life events and psychotic experiences in children at twelve years in a birth cohort study. Schizophrenia Research, 152(1), 158-163. https://doi.org/10.1016/j.schres.2013.11.006

Background: International studies indicate that the median prevalence of psychotic experiences in children is 7%. It has been proposed that environmental stress during pregnancy may affect the neurodevelopment of the foetus and lead to a vulnerabilit... Read More about Perinatal maternal life events and psychotic experiences in children at twelve years in a birth cohort study.

Familial aggregation of gout and relative genetic and environmental contributions: a nationwide population study in Taiwan (2013)
Journal Article
Kuo, C., Grainge, M. J., See, L., Yu, K., Luo, S., Valdes, A. M., …Doherty, M. (2015). Familial aggregation of gout and relative genetic and environmental contributions: a nationwide population study in Taiwan. Annals of the Rheumatic Diseases, 74(2), 369-374. https://doi.org/10.1136/annrheumdis-2013-204067

© 2015, BMJ Publishing Group. All rights reserved. Objective: To examine familial aggregation of gout and to estimate the heritability and environmental contributions to gout susceptibility in the general population. Methods: Using data from the Nati... Read More about Familial aggregation of gout and relative genetic and environmental contributions: a nationwide population study in Taiwan.