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Treatment decisions and survival for people with small-cell lung cancer

Powell, H.A.; Tata, L.J.; Baldwin, D.R.; Potter, V.A.; Stanley, R.A.; Khakwani, A.; Hubbard, R.B.

Authors

H.A. Powell

D.R. Baldwin

V.A. Potter

R.A. Stanley

A. Khakwani aamir.khakwani@nottingham.ac.uk

RICHARD HUBBARD richard.hubbard@nottingham.ac.uk
Blf/Gsk Professor of Epidemiological Resp Research



Abstract

Background: Chemotherapy improves survival for many patients with SCLC, and hence it is important to understand variations in practice and outcomes for this treatment strategy.

Methods: We used the National Lung Cancer Audit and Hospital Episodes Statistics to determine the proportion of patients who received chemotherapy for SCLC, and assess the effects of patient and organisational factors on the odds of receiving chemotherapy and of completing four cycles. We calculated median survival and used Cox regression to determine factors that predicted survival.

Results: Of 15 091 cases of SCLC, 70% received at least one cycle of chemotherapy. More deprived people were less likely to receive chemotherapy, but patients were more likely to receive chemotherapy, and to complete Xfour cycles, if they were referred to the lung cancer team by their GP. Median survival for those treated with chemotherapy was 12.9 months for limited and 7.3 months for extensive stage disease.

Conclusions: The Linked NLCA and HES data provide real-life measures of survival in people treated with chemotherapy and
show how this is influenced by patient and tumour characteristics. These data show the characteristics of patients who are less likely to complete a full course of treatment, an adverse predictor of survival.

Citation

Powell, H., Tata, L., Baldwin, D., Potter, V., Stanley, R., Khakwani, A., & Hubbard, R. (in press). Treatment decisions and survival for people with small-cell lung cancer. British Journal of Cancer, 110(4), https://doi.org/10.1038/bjc.2013.812

Journal Article Type Article
Acceptance Date Dec 6, 2013
Online Publication Date Jan 7, 2014
Deposit Date Oct 24, 2016
Publicly Available Date Oct 24, 2016
Journal British Journal of Cancer
Print ISSN 0007-0920
Electronic ISSN 1532-1827
Publisher Cancer Research UK
Peer Reviewed Peer Reviewed
Volume 110
Issue 4
DOI https://doi.org/10.1038/bjc.2013.812
Keywords lung neoplasm; small cell; survival; chemotherapy; radiotherapy
Public URL http://eprints.nottingham.ac.uk/id/eprint/37770
Publisher URL http://www.nature.com/bjc/journal/v110/n4/full/bjc2013812a.html
Related Public URLs http://dx.doi.org/10.1038/bjc.2013.812
Copyright Statement Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by-nd-sa/4.0
Additional Information Supplementary information available for this article at http://www.nature.com/b...pinfo/bjc2013812s1.html

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by-nd-sa/4.0





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