Signalling Paediatric Side Effects using an Ensemble of Simple Study Designs
Reps, Jenna; M. Garibaldi, Jonathan; Aickelin, Uwe; Soria, Daniele; E. Gibson, Jack; B. Hubbard, Richard
JONATHAN GARIBALDI JON.GARIBALDI@NOTTINGHAM.AC.UK
Professor of Computer Science
JACK GIBSON email@example.com
Assistant Professor in Epidemiology
RICHARD HUBBARD firstname.lastname@example.org
Blf/Gsk Professor of Epidemiological Resp Research
Background: Children are frequently prescribed medication `o-label', meaning there has not been sucient testing of the medication to determine its safety or eectiveness. The main reason this safety knowledge is lacking is due to
ethical restrictions that prevent children from being included in the majority of clinical trials.
Methods: Multiple measures of association are calculated for each drug and medical event pair and these are used as features that are fed into a classifier to determine the likelihood of the drug and medical event pair corresponding to an adverse drug reaction. The classier is trained using known adverse drug reactions or known non-adverse drug reaction relationships.
Results: The novel ensemble framework obtained a false positive rate of 0:149, a sensitivity of 0:547 and a specificity of 0:851 when implemented on a reference set
of drug and medical event pairs. The novel framework consistently outperformed each individual simple study design.
Conclusion: This research shows that it is possible to exploit the mechanism of causality and presents a framework for signalling adverse drug reactions eectively.
Reps, J., M. Garibaldi, J., Aickelin, U., Soria, D., E. Gibson, J., & B. Hubbard, R. (2014). Signalling Paediatric Side Effects using an Ensemble of Simple Study Designs. Drug Safety, 37(3), 163-170. https://doi.org/10.1007/s40264-014-0137-z
|Journal Article Type||Article|
|Online Publication Date||Feb 19, 2014|
|Deposit Date||Sep 29, 2014|
|Publicly Available Date||Sep 29, 2014|
|Peer Reviewed||Peer Reviewed|
|Keywords||Biomedical Informatics, Data Mining|
|Copyright Statement||Copyright information regarding this work can be found at the following address: http://eprints.nottingh.../end_user_agreement.pdf|
|Additional Information||The final publication is available at Springer via http://dx.doi.org/10.1007/s40264-014-0137-z|
Copyright information regarding this work can be found at the following address: http://eprints.nottingham.ac.uk/end_user_agreement.pdf
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