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Signalling Paediatric Side Effects using an Ensemble of Simple Study Designs

Reps, Jenna; M. Garibaldi, Jonathan; Aickelin, Uwe; Soria, Daniele; E. Gibson, Jack; B. Hubbard, Richard

Authors

Jenna Reps

Jonathan M. Garibaldi

Uwe Aickelin

Daniele Soria

Jack E. Gibson

Richard B. Hubbard

Abstract

Background: Children are frequently prescribed medication `o-label', meaning there has not been sucient testing of the medication to determine its safety or eectiveness. The main reason this safety knowledge is lacking is due to
ethical restrictions that prevent children from being included in the majority of clinical trials.

Methods: Multiple measures of association are calculated for each drug and medical event pair and these are used as features that are fed into a classifier to determine the likelihood of the drug and medical event pair corresponding to an adverse drug reaction. The classier is trained using known adverse drug reactions or known non-adverse drug reaction relationships.

Results: The novel ensemble framework obtained a false positive rate of 0:149, a sensitivity of 0:547 and a specificity of 0:851 when implemented on a reference set
of drug and medical event pairs. The novel framework consistently outperformed each individual simple study design.

Conclusion: This research shows that it is possible to exploit the mechanism of causality and presents a framework for signalling adverse drug reactions eectively.

Journal Article Type Article
Publication Date 2014-03
Journal Drug Safety
Print ISSN 0114-5916
Electronic ISSN 1179-1942
Publisher Springer Verlag
Peer Reviewed Peer Reviewed
Volume 37
Issue 3
Pages 163-170
Institution Citation Reps, J. M., Garibaldi, J. M., Aickelin, U., Soria, D., Gibson, J. E., & Hubbard, R. B. (2014). Signalling Paediatric Side Effects using an Ensemble of Simple Study Designs. Drug Safety, 37(3), 163-170. https://doi.org/10.1007/s40264-014-0137-z
DOI https://doi.org/10.1007/s40264-014-0137-z
Keywords Biomedical Informatics, Data Mining
Publisher URL http://link.springer.com/article/10.1007/s40264-014-0137-z
Copyright Statement Copyright information regarding this work can be found at the following address: http://eprints.nottingh.../end_user_agreement.pdf
Additional Information The final publication is available at Springer via http://dx.doi.org/10.1007/s40264-014-0137-z

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://eprints.nottingham.ac.uk/end_user_agreement.pdf




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