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Rate of improvement of CF life expectancy exceeds that of general population: observational death registration study

Hurley, Matthew; McKeever, Tricia M.; Prayle, Andrew P.; Smyth, Alan R.; Fogarty, Andrew W.

Authors

Matthew Hurley

TRICIA MCKEEVER tricia.mckeever@nottingham.ac.uk
Professor of Epidemiology and Medical Statistics

Andrew P. Prayle

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ALAN SMYTH alan.smyth@nottingham.ac.uk
Professor of Child Health

ANDREW FOGARTY andrew.fogarty@nottingham.ac.uk
Clinical Associate Professor & Reader in Clinical Epidemiology



Abstract

Background: It is unclear why cystic fibrosis (CF) survival has improved. We wished to quantify increases in CF median age of death in the context of general population survival improvement.
Method: Death registration data analysis (US, England & Wales (E&W)—1972–2009).
Results: CF median age of death is higher in US than E&W and greater for males, opposite to that of death from all causes. CF median age of death has increased by 0.543 life years per year (E&W, US combined (95% confidence interval 0.506, 0.582)). The difference in median age at death between those dying from all causes and CF decreased in both territories. CF median age of death for males is greater than for females in both territories. This gap has not narrowed.
Conclusion: The median age of death of people with CF is improving more rapidly than that of the general population in US and E&W.

Journal Article Type Article
Publication Date Jul 1, 2014
Journal Journal of Cystic Fibrosis
Print ISSN 1569-1993
Electronic ISSN 1873-5010
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 13
Issue 4
APA6 Citation Hurley, M., McKeever, T. M., Prayle, A. P., Smyth, A. R., & Fogarty, A. W. (2014). Rate of improvement of CF life expectancy exceeds that of general population: observational death registration study. Journal of Cystic Fibrosis, 13(4), doi:10.1016/j.jcf.2013.12.002
DOI https://doi.org/10.1016/j.jcf.2013.12.002
Keywords Cystic fibrosis; Survival; Mortality; Healthcare
Publisher URL http://www.sciencedirect.com/science/article/pii/S1569199313002270
Copyright Statement Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0





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