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Antibody-targeting of ultra-small nanoparticles enhances imaging sensitivity and enables longitudinal tracking of multiple myeloma (2019)
Journal Article
Detappe, A., Reidy, M., Yu, Y., Mathieu, C., Nguyen, H. V., Coroller, T. P., …Ghoroghchian, P. P. (2019). Antibody-targeting of ultra-small nanoparticles enhances imaging sensitivity and enables longitudinal tracking of multiple myeloma. Nanoscale, https://doi.org/10.1039/c9nr06512a

Monitoring malignant progression and disease recurrence post-therapy are central challenges to improving the outcomes of patients with multiple myeloma (MM). Whereas current detection methods that rely upon bone marrow examination allow for precise m... Read More about Antibody-targeting of ultra-small nanoparticles enhances imaging sensitivity and enables longitudinal tracking of multiple myeloma.

Polyoxazoline-Based Bottlebrush and Brush-Arm Star Polymers via ROMP: Syntheses and Applications as Organic Radical Contrast Agents (2019)
Journal Article
Alvaradejo, G. G., Nguyen, H. V., Harvey, P., Gallagher, N. M., Le, D., Ottaviani, M. F., …Johnson, J. A. (2019). Polyoxazoline-Based Bottlebrush and Brush-Arm Star Polymers via ROMP: Syntheses and Applications as Organic Radical Contrast Agents. ACS Macro Letters, 8(4), 473-478. https://doi.org/10.1021/acsmacrolett.9b00016

The synthesis of functional poly(2-alkyl-2-oxazoline) (PAOx) copolymers with complex nanoarchitectures using a graft-through ring-opening metathesis polymerization (ROMP) approach is described. First, well-defined norbornene-terminated poly(2-ethyl-2... Read More about Polyoxazoline-Based Bottlebrush and Brush-Arm Star Polymers via ROMP: Syntheses and Applications as Organic Radical Contrast Agents.

Sensing Uranyl(VI) Ions by Coordination and Energy Transfer to a Luminescent Europium(III) Complex (2018)
Journal Article
Harvey, P., Nonat, A., Platas-Iglesias, C., Natrajan, L. S., & Charbonnière, L. J. (2018). Sensing Uranyl(VI) Ions by Coordination and Energy Transfer to a Luminescent Europium(III) Complex. Angewandte Chemie, 130(31), 10069-10072. https://doi.org/10.1002/ange.201805316

The release of uranyl(VI) is a hazardous environmental issue, with limited ways to monitor accumulation in situ. Here, we present a method for the detection of uranyl(VI) ions through the utilization of a unique fluorescence energy transfer process t... Read More about Sensing Uranyl(VI) Ions by Coordination and Energy Transfer to a Luminescent Europium(III) Complex.

Critical analysis of the limitations of Bleaney's theory of magnetic anisotropy in paramagnetic lanthanide coordination complexes (2014)
Journal Article
Funk, A. M., Finney, K. N. A., Harvey, P., Kenwright, A. M., Neil, E. R., Rogers, N. J., …Parker, D. (2014). Critical analysis of the limitations of Bleaney's theory of magnetic anisotropy in paramagnetic lanthanide coordination complexes. Chemical Science, 6(3), 1655-1662. https://doi.org/10.1039/c4sc03429e

The origins of the breakdown of Bleaney's theory of magnetic anisotropy are described, based on an analysis of eleven different complexes of the second half of the 4f elements that form isostructural series. An examination of the chemical shift and r... Read More about Critical analysis of the limitations of Bleaney's theory of magnetic anisotropy in paramagnetic lanthanide coordination complexes.

Ratiometric detection of enzyme turnover and flavin reduction using rare-earth upconverting phosphors (2014)
Journal Article
Harvey, P., Oakland, C., Driscoll, M. D., Hay, S., & Natrajan, L. S. (2014). Ratiometric detection of enzyme turnover and flavin reduction using rare-earth upconverting phosphors. Dalton Transactions, 43(14), 5265-5268. https://doi.org/10.1039/c4dt00356j

Gd4O2S:Yb:Tm rare-earth upconversion phosphors have been utilised to monitor the redox behaviour of flavin mononucleotide and report on the turnover of a flavo-protein, (pentaerythritol tetranitrate reductase). The presence of two bands separated by... Read More about Ratiometric detection of enzyme turnover and flavin reduction using rare-earth upconverting phosphors.

Moving the goal posts: enhancing the sensitivity of PARASHIFT proton magnetic resonance imaging and spectroscopy (2013)
Journal Article
Harvey, P., Blamire, A. M., Wilson, J. I., Finney, K. N. A., Funk, A. M., Senanayake, P. K., & Parker, D. (2013). Moving the goal posts: enhancing the sensitivity of PARASHIFT proton magnetic resonance imaging and spectroscopy. Chemical Science, 4(11), 4251-4258. https://doi.org/10.1039/c3sc51526e

Paramagnetic probes for chemical shift imaging are described, in which a reporting tert-butyl resonance is integrated and placed about 6 to 6.5 Å from a lanthanide ion. At this distance, the resonance is shifted to a region of the 1H NMR spectral win... Read More about Moving the goal posts: enhancing the sensitivity of PARASHIFT proton magnetic resonance imaging and spectroscopy.

Characterisation and evaluation of paramagnetic fluorine labelled glycol chitosan conjugates for 19F and 1H magnetic resonance imaging (2013)
Journal Article
Parker, D., De Luca, E., Botta, M., Harvey, P., Chalmers, K. H., Mishra, A., …Wilson, J. I. (2014). Characterisation and evaluation of paramagnetic fluorine labelled glycol chitosan conjugates for 19F and 1H magnetic resonance imaging. Journal of Biological Inorganic Chemistry, 19(2), 215-227. https://doi.org/10.1007/s00775-013-1028-y

Medium molecular weight glycol chitosan conjugates have been prepared, linked by an amide bond to paramagnetic Gd(III), Ho(III) and Dy(III) macrocyclic complexes in which a trifluoromethyl reporter group is located 6.5 Å from the paramagnetic centre.... Read More about Characterisation and evaluation of paramagnetic fluorine labelled glycol chitosan conjugates for 19F and 1H magnetic resonance imaging.