Moving the goal posts: enhancing the sensitivity of PARASHIFT proton magnetic resonance imaging and spectroscopy

Harvey, Peter; Blamire, Andrew M.; Wilson, J. Ian; Finney, Katie-Louise N. A.; Funk, Alexander M.; Senanayake, P. Kanthi; Parker, David

Abstract

Paramagnetic probes for chemical shift imaging are described, in which a reporting tert-butyl resonance is integrated and placed about 6 to 6.5 Å from a lanthanide ion. At this distance, the resonance is shifted to a region of the 1H NMR spectral window far away from the usual 0–12 ppm range, permitting selective observation. Furthermore, judicious selection of the lanthanide ion, according to the applied magnetic field strength, leads to relaxation rate enhancements of the order of 100–200, permitting more rapid data acquisition per unit time in both spectroscopy and imaging experiments. The enhanced sensitivity allows the detection of these complexes in mice within a few minutes using shift imaging, following tail vein injection of doses of the order of 0.1 mmol kg−1.

Citation

Harvey, P., Blamire, A. M., Wilson, J. I., Finney, K. N. A., Funk, A. M., Senanayake, P. K., & Parker, D. (2013). Moving the goal posts: enhancing the sensitivity of PARASHIFT proton magnetic resonance imaging and spectroscopy. Chemical Science, 4(11), 4251-4258. https://doi.org/10.1039/c3sc51526e

• Journal Article Type: Article
• Acceptance Date: Aug 19, 2013
• Online Publication Date: Aug 19, 2013
• Publication Date: Aug 19, 2013
• Deposit Date: Oct 24, 2019
• Journal: Chemical Science
• Print ISSN: 2041-6520
• Electronic ISSN: 2041-6539
• Publisher: Royal Society of Chemistry
• Peer Reviewed: Peer Reviewed
• Volume: 4
• Issue: 11
• Pages: 4251-4258
• DOI: https://doi.org/10.1039/c3sc51526e
• Public URL: https://nottingham-repository.worktribe.com/output/2829632
• Publisher URL: https://pubs.rsc.org/en/content/articlelanding/2013/SC/c3sc51526e#!divAbstract