Skip to main content

Research Repository

Advanced Search

Polyoxazoline-Based Bottlebrush and Brush-Arm Star Polymers via ROMP: Syntheses and Applications as Organic Radical Contrast Agents

Alvaradejo, Gabriela Gil; Nguyen, Hung V.-T.; Harvey, Peter; Gallagher, Nolan M.; Le, Dao; Ottaviani, M. Francesca; Jasanoff, Alan; Delaittre, Guillaume; Johnson, Jeremiah A.

Polyoxazoline-Based Bottlebrush and Brush-Arm Star Polymers via ROMP: Syntheses and Applications as Organic Radical Contrast Agents Thumbnail


Authors

Gabriela Gil Alvaradejo

Hung V.-T. Nguyen

Nolan M. Gallagher

Dao Le

M. Francesca Ottaviani

Alan Jasanoff

Guillaume Delaittre

Jeremiah A. Johnson



Abstract

Copyright © 2019 American Chemical Society. The synthesis of functional poly(2-alkyl-2-oxazoline) (PAOx) copolymers with complex nanoarchitectures using a graft-through ring-opening metathesis polymerization (ROMP) approach is described. First, well-defined norbornene-terminated poly(2-ethyl-2-oxazoline) (PEtOx) macromonomers (MM) were prepared by cationic ring-opening polymerization. ROMP of these MMs produced bottlebrush copolymers with PEtOx side chains. In addition, PEtOx-based branched MMs bearing a terminal alkyne group were prepared and conjugated to an azide-containing bis-spirocyclohexyl nitroxide via Cu-catalyzed azide-alkyne cycloaddition (CuAAC). ROMP of this branched MM, followed by in situ cross-linking, provided PEtOx-based brush-arm star polymers (BASPs) with nitroxide radicals localized at the core-shell interface. These PEtOx-based nitroxide-containing BASPs displayed relaxivity values on par with state-of-the-art polyethylene glycol (PEG)-based nitroxide materials, making them promising as organic radical contrast agents for metal-free magnetic resonance imaging (MRI).

Citation

Alvaradejo, G. G., Nguyen, H. V., Harvey, P., Gallagher, N. M., Le, D., Ottaviani, M. F., …Johnson, J. A. (2019). Polyoxazoline-Based Bottlebrush and Brush-Arm Star Polymers via ROMP: Syntheses and Applications as Organic Radical Contrast Agents. ACS Macro Letters, 8(4), 473-478. https://doi.org/10.1021/acsmacrolett.9b00016

Journal Article Type Article
Acceptance Date Mar 11, 2019
Online Publication Date Apr 4, 2019
Publication Date Apr 16, 2019
Deposit Date Oct 23, 2019
Publicly Available Date Mar 28, 2024
Journal ACS Macro Letters
Electronic ISSN 2161-1653
Publisher American Chemical Society
Peer Reviewed Peer Reviewed
Volume 8
Issue 4
Pages 473-478
DOI https://doi.org/10.1021/acsmacrolett.9b00016
Public URL https://nottingham-repository.worktribe.com/output/2828753
Publisher URL https://pubs.acs.org/doi/10.1021/acsmacrolett.9b00016
Additional Information This document is the unedited Author’s version of a Submitted Work that was subsequently accepted for publication in ACS Macro Letters, copyright © American Chemical Society after peer review. To access the final edited and published work see https://pubs.acs.org/doi/10.1021/acsmacrolett.9b00016.

Files




You might also like



Downloadable Citations