Image-guided neural activity manipulation with a paramagnetic drug

Bricault, Sarah; Barandov, Ali; Harvey, Peter; DeTienne, Elizabeth; Hai, Aviad; Jasanoff, Alan

Abstract

© 2020, The Author(s). Targeted manipulations of neural activity are essential approaches in neuroscience and neurology, but monitoring such procedures in the living brain remains a significant challenge. Here we introduce a paramagnetic analog of the drug muscimol that enables targeted neural inactivation to be performed with feedback from magnetic resonance imaging. We validate pharmacological properties of the compound in vitro, and show that its distribution in vivo reliably predicts perturbations to brain activity.

Citation

Bricault, S., Barandov, A., Harvey, P., DeTienne, E., Hai, A., & Jasanoff, A. (2020). Image-guided neural activity manipulation with a paramagnetic drug. Nature Communications, 11(1), Article 136. https://doi.org/10.1038/s41467-019-13933-5

• Journal Article Type: Article
• Acceptance Date: Dec 4, 2019
• Online Publication Date: Jan 9, 2020
• Publication Date: 2020
• Deposit Date: Jan 13, 2020
• Publicly Available Date: Jan 13, 2020
• Journal: Nature Communications
• Electronic ISSN: 2041-1723
• Publisher: Nature Publishing Group
• Peer Reviewed: Peer Reviewed
• Volume: 11
• Issue: 1
• Article Number: 136
• DOI: https://doi.org/10.1038/s41467-019-13933-5
• Keywords: General Biochemistry, Genetics and Molecular Biology; General Physics and Astronomy; General Chemistry
• Public URL: https://nottingham-repository.worktribe.com/output/3706315
• Publisher URL: https://www.nature.com/articles/s41467-019-13933-5