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Image-guided neural activity manipulation with a paramagnetic drug

Bricault, Sarah; Barandov, Ali; Harvey, Peter; DeTienne, Elizabeth; Hai, Aviad; Jasanoff, Alan

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Authors

Sarah Bricault

Ali Barandov

Elizabeth DeTienne

Aviad Hai

Alan Jasanoff



Abstract

© 2020, The Author(s). Targeted manipulations of neural activity are essential approaches in neuroscience and neurology, but monitoring such procedures in the living brain remains a significant challenge. Here we introduce a paramagnetic analog of the drug muscimol that enables targeted neural inactivation to be performed with feedback from magnetic resonance imaging. We validate pharmacological properties of the compound in vitro, and show that its distribution in vivo reliably predicts perturbations to brain activity.

Citation

Bricault, S., Barandov, A., Harvey, P., DeTienne, E., Hai, A., & Jasanoff, A. (2020). Image-guided neural activity manipulation with a paramagnetic drug. Nature Communications, 11(1), Article 136. https://doi.org/10.1038/s41467-019-13933-5

Journal Article Type Article
Acceptance Date Dec 4, 2019
Online Publication Date Jan 9, 2020
Publication Date 2020
Deposit Date Jan 13, 2020
Publicly Available Date Jan 13, 2020
Journal Nature Communications
Electronic ISSN 2041-1723
Publisher Nature Publishing Group
Peer Reviewed Peer Reviewed
Volume 11
Issue 1
Article Number 136
DOI https://doi.org/10.1038/s41467-019-13933-5
Keywords General Biochemistry, Genetics and Molecular Biology; General Physics and Astronomy; General Chemistry
Public URL https://nottingham-repository.worktribe.com/output/3706315
Publisher URL https://www.nature.com/articles/s41467-019-13933-5

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