Antibody-targeting of ultra-small nanoparticles enhances imaging sensitivity and enables longitudinal tracking of multiple myeloma

Detappe, Alexandre; Reidy, Mairead; Yu, Yingjie; Mathieu, Clelia; Nguyen, Hung V.-T.; Coroller, Thibaud P.; Lam, Fred; Jarolim, Petr; Harvey, Peter; Protti, Andrea; Nguyen, Quang De; Johnson, Jeremiah A.; Cremillieux, Yannick; Tillement, Olivier; Ghobrial, Irene M.; Ghoroghchian, P. Peter

Abstract

Monitoring malignant progression and disease recurrence post-therapy are central challenges to improving the outcomes of patients with multiple myeloma (MM). Whereas current detection methods that rely upon bone marrow examination allow for precise monitoring of minimal residual disease and can help to elucidate clonal evolution, they do not take into account the spatial heterogeneity of the tumor microenvironment. As such, they are uninformative as to the localization of malignant plasma cells and may lead to false negative results. With respect to the latter challenge, clinically-available imaging agents are neither sufficiently sensitive nor specific enough to detect minute plasma cell populations. Here, we sought to explore methods by which to improve detection of MM cells within their natural bone marrow environment, using whole-animal magnetic resonance imaging to longitudinally monitor early-stage disease as well as to enhance tumor detection after systemic therapy. We conducted a proof-of-concept study to demonstrate that ultra-small (

Citation

Detappe, A., Reidy, M., Yu, Y., Mathieu, C., Nguyen, H. V.-T., Coroller, T. P., Lam, F., Jarolim, P., Harvey, P., Protti, A., Nguyen, Q. D., Johnson, J. A., Cremillieux, Y., Tillement, O., Ghobrial, I. M., & Ghoroghchian, P. P. (2019). Antibody-targeting of ultra-small nanoparticles enhances imaging sensitivity and enables longitudinal tracking of multiple myeloma. Nanoscale, 11(43), 20485-20496. https://doi.org/10.1039/c9nr06512a

• Journal Article Type: Article
• Acceptance Date: Sep 23, 2019
• Online Publication Date: Oct 16, 2019
• Publication Date: Nov 21, 2019
• Deposit Date: Oct 28, 2019
• Publicly Available Date: Oct 28, 2019
• Journal: Nanoscale
• Print ISSN: 2040-3364
• Electronic ISSN: 2040-3372
• Publisher: Royal Society of Chemistry
• Peer Reviewed: Peer Reviewed
• Volume: 11
• Issue: 43
• Pages: 20485-20496
• DOI: https://doi.org/10.1039/c9nr06512a
• Keywords: General Materials Science
• Public URL: https://nottingham-repository.worktribe.com/output/2976918
• Publisher URL: https://pubs.rsc.org/en/Content/ArticleLanding/2019/NR/C9NR06512A#!divAbstract
• Contract Date: Oct 28, 2019