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Association between benzodiazepine use and exacerbations and mortality in patients with asthma: a matched case-control and survival analysis using the United Kingdom Clinical Practice Research Datalink (2015)
Journal Article
Nakafero, G., Sanders, R. D., Nguyen-Van-Tam, J. S., & Myles, P. R. (2015). Association between benzodiazepine use and exacerbations and mortality in patients with asthma: a matched case-control and survival analysis using the United Kingdom Clinical Practice Research Datalink. Pharmacoepidemiology and Drug Safety, 24(8), 793-802. https://doi.org/10.1002/pds.3799

Purpose: To investigate the association between the GABAergic drugs, benzodiazepines or zopiclone, and the occurrence of asthma exacerbations and subsequent mortality in a cohort of asthma patients. Methods: 105,747 patients without asthma exacerba... Read More about Association between benzodiazepine use and exacerbations and mortality in patients with asthma: a matched case-control and survival analysis using the United Kingdom Clinical Practice Research Datalink.

Plasma lipid biomarker signatures in squamous carcinoma and adenocarcinoma lung cancer patients (2015)
Journal Article
Ravipati, S., Baldwin, D. R., Barr, H. L., Fogarty, A. W., & Barrett, D. A. (in press). Plasma lipid biomarker signatures in squamous carcinoma and adenocarcinoma lung cancer patients. Metabolomics, 11(6), https://doi.org/10.1007/s11306-015-0811-x

There is a clinical need for reliable biomarkers for lung cancer that permit early diagnosis of the disease and provide prediction of histological phenotype. A prospective study design was used with a study population of patients with suspected lung... Read More about Plasma lipid biomarker signatures in squamous carcinoma and adenocarcinoma lung cancer patients.

Global incidence and mortality of idiopathic pulmonary fibrosis: a systematic review (2015)
Journal Article
Hutchinson, J. P., Fogarty, A. W., Hubbard, R. B., & McKeever, T. M. (2015). Global incidence and mortality of idiopathic pulmonary fibrosis: a systematic review. European Respiratory Journal, 46(3), https://doi.org/10.1183/09031936.00185114

Introduction: As idiopathic pulmonary fibrosis emerges as an important public health problem, there is a need to coordinate data on incidence and mortality globally. This study aims to systematically assess all available studies to investigate the gl... Read More about Global incidence and mortality of idiopathic pulmonary fibrosis: a systematic review.

Physical activity for smoking cessation in pregnancy: randomised controlled trial (2015)
Journal Article
Ussher, M., Lewis, S., Aveyard, P., Manyonda, I., West, R., Lewis, B., …Coleman, T. (2015). Physical activity for smoking cessation in pregnancy: randomised controlled trial. BMJ, 350, Article h2145. https://doi.org/10.1136/bmj.h2145

Objective: To determine the effectiveness of a physical activity intervention for smoking cessation during pregnancy. Design: Parallel group, randomised controlled, multicentre trial. Setting: 13 hospitals in England, April 2009 to January 20... Read More about Physical activity for smoking cessation in pregnancy: randomised controlled trial.

Complications and mortality in hereditary hemorrhagic telangiectasia: a population-based study (2015)
Journal Article
Donaldson, J., McKeever, T. M., Hall, I. P., Hubbard, R., & Fogarty, A. W. (2015). Complications and mortality in hereditary hemorrhagic telangiectasia: a population-based study. Neurology, 84(18), https://doi.org/10.1212/WNL.0000000000001538

OBJECTIVES: Studies report that the risks of significant neurologic complications (including stroke, cerebral abscess, and migraine) and hemorrhagic sequelae are high in patients with hereditary hemorrhagic telangiectasia (HHT), and that life expe... Read More about Complications and mortality in hereditary hemorrhagic telangiectasia: a population-based study.

Direct targeting of risk factors significantly increases the detection of liver cirrhosis in primary care: a cross-sectional diagnostic study utilising transient elastography (2015)
Journal Article
Harman, D. J., Ryder, S. D., James, M. W., Jelpke, M., Ottey, D. S., Wilkes, E. A., …Guha, I. N. (2015). Direct targeting of risk factors significantly increases the detection of liver cirrhosis in primary care: a cross-sectional diagnostic study utilising transient elastography. BMJ Open, 5(4), Article e007516. https://doi.org/10.1136/bmjopen-2014-007516

OBJECTIVES: To assess the feasibility of a novel diagnostic algorithm targeting patients with risk factors for chronic liver disease in a community setting. DESIGN: Prospective cross-sectional study. SETTING: Two primary care practices (adult... Read More about Direct targeting of risk factors significantly increases the detection of liver cirrhosis in primary care: a cross-sectional diagnostic study utilising transient elastography.

Risk factors for long-bone fractures in children up to 5 years of age: a nested case–control study (2015)
Journal Article
Baker, R., Orton, E., Tata, L. J., & Kendrick, D. (2015). Risk factors for long-bone fractures in children up to 5 years of age: a nested case–control study. Archives of Disease in Childhood, 100(5), https://doi.org/10.1136/archdischild-2013-305715

Aim: To investigate risk factors for first long-bone fractures in children up to 5 years old in order to provide evidence about which families could benefit from injury prevention interventions. Methods: Population-based matched nested case–control... Read More about Risk factors for long-bone fractures in children up to 5 years of age: a nested case–control study.

Nicotine replacement therapy in pregnancy and major congenital anomalies in offspring (2015)
Journal Article
Dhalwani, N. N., Szatkowski, L., Coleman, T., Fiaschi, L., & Tata, L. J. (2015). Nicotine replacement therapy in pregnancy and major congenital anomalies in offspring. Pediatrics, 135(5), https://doi.org/10.1542/peds.2014-2560

BACKGROUND AND OBJECTIVES: Nicotine replacement therapy (NRT) is now being used as a smoking cessation aid during pregnancy, although little is known about fetal safety. We assessed the relationship between early pregnancy exposure to NRT or smoking... Read More about Nicotine replacement therapy in pregnancy and major congenital anomalies in offspring.

Medical Crises in Older People: cohort study of older people attending acute medical units, developmental work and randomised controlled trial of a specialist geriatric medical intervention for high-risk older people; cohort study of older people with mental health problems admitted to hospital, developmental work and randomised controlled trial of a specialist medical and mental health unit for general hospital patients with delirium and dementia; and cohort study of residents of care homes and interview study of health-care provision to residents of care homes (2015)
Journal Article
Gladman, J., Harwood, R., Conroy, S., Logan, P., Elliott, R., Jones, R., …Frowd, N. (2015). Medical Crises in Older People: cohort study of older people attending acute medical units, developmental work and randomised controlled trial of a specialist geriatric medical intervention for high-risk older people; cohort study of older people with mental health problems admitted to hospital, developmental work and randomised controlled trial of a specialist medical and mental health unit for general hospital patients with delirium and dementia; and cohort study of residents of care homes and interview study of health-care provision to residents of care homes. Programme Grants for Applied Research, 3(4), 1-410. https://doi.org/10.3310/pgfar03040

Background This programme of research addressed shortcomings in the care of three groups of older patients: patients discharged from acute medical units (AMUs), patients with dementia and delirium admitted to general hospitals, and care home residen... Read More about Medical Crises in Older People: cohort study of older people attending acute medical units, developmental work and randomised controlled trial of a specialist geriatric medical intervention for high-risk older people; cohort study of older people with mental health problems admitted to hospital, developmental work and randomised controlled trial of a specialist medical and mental health unit for general hospital patients with delirium and dementia; and cohort study of residents of care homes and interview study of health-care provision to residents of care homes.

Socioeconomic variation in the incidence of childhood coeliac disease in the UK (2015)
Journal Article
Zingone, F., West, J., Crooks, C. J., Fleming, K. M., Card, T. R., Ciacci,, C., & Tata, L. J. (2015). Socioeconomic variation in the incidence of childhood coeliac disease in the UK. Archives of Disease in Childhood, 100(5), https://doi.org/10.1136/archdischild-2014-307105

BACKGROUND: Serological studies indicate that evidence of coeliac disease (CD) exists in about 1% of all children, but we lack estimates of current diagnostic patterns among children and how they vary by socioeconomic group. METHODS: We identifie... Read More about Socioeconomic variation in the incidence of childhood coeliac disease in the UK.

Do cravings predict smoking cessation in smokers calling a national quit line: secondary analyses from a randomised trial for the utility of ‘urges to smoke’ measures (2015)
Journal Article
Taggar, J. S., Lewis, S., Docherty, G., Bauld, L., McEwen, A., & Coleman, T. (in press). Do cravings predict smoking cessation in smokers calling a national quit line: secondary analyses from a randomised trial for the utility of ‘urges to smoke’ measures. Substance Abuse Treatment, Prevention, and Policy, 10(15), https://doi.org/10.1186/s13011-015-0011-8

BACKGROUND: Single-item urges to smoke measures have been contemplated as important measures of nicotine dependence This study aimed to prospectively determine the relationships between measures of craving to smoke and smoking cessation, and compare... Read More about Do cravings predict smoking cessation in smokers calling a national quit line: secondary analyses from a randomised trial for the utility of ‘urges to smoke’ measures.

Prevalence of smoking among patients treated in NHS hospitals in England in 2010/11: a national audit (2015)
Journal Article
Szatkowski, L., Murray, R., Hubbard, R. B., Agrawal, S., Huang, Y., & Britton, J. (2015). Prevalence of smoking among patients treated in NHS hospitals in England in 2010/11: a national audit. Thorax, 70(5), https://doi.org/10.1136/thoraxjnl-2014-206285

Using data from The Health Improvement Network and Hospital Episode Statistics, we investigate smoking prevalence, number of smokers treated and opportunities for cessation intervention among patients treated in National Health Service (NHS) hospital... Read More about Prevalence of smoking among patients treated in NHS hospitals in England in 2010/11: a national audit.

Cardiovascular risk factors and cognitive decline in older people with type 2 diabetes (2015)
Journal Article
Feinkohl, I., Keller, M., Robertson, C. M., Morling, J. R., McLachlan, S., Frier, B. M., …Price, J. F. (2015). Cardiovascular risk factors and cognitive decline in older people with type 2 diabetes. Diabetologia, 58(7), https://doi.org/10.1007/s00125-015-3581-0

AIMS/HYPOTHESIS: The aim of this work was to assess the role of well-established cardiovascular risk factors in the late-life cognitive decline of patients with type 2 diabetes. METHODS: Data from 831 participants (aged 60-75 years) attending the... Read More about Cardiovascular risk factors and cognitive decline in older people with type 2 diabetes.

Abstinence and relapse among smokers who use varenicline in a quit attempt-a pooled analysis of randomized controlled trials: Relapse and abstinence in smokers treated with varenicline (2015)
Journal Article
Agboola, S. A., Coleman, T., McNeill, A., & Leonardi-Bee, J. (2015). Abstinence and relapse among smokers who use varenicline in a quit attempt-a pooled analysis of randomized controlled trials: Relapse and abstinence in smokers treated with varenicline. Addiction, 110(7), 1182-1193. doi:10.1111/add.12941

Background and aims Varenicline increases the likelihood of long-term abstinence following a quit attempt. It has been suggested that 1) part of its benefit arises from ‘recruiting into abstinence’ smokers who are not able to stop on the target quit... Read More about Abstinence and relapse among smokers who use varenicline in a quit attempt-a pooled analysis of randomized controlled trials: Relapse and abstinence in smokers treated with varenicline.

A systematic review and meta-analysis of thiazide-induced hyponatraemia: time to reconsider electrolyte monitoring regimens after thiazide initiation? (2015)
Journal Article
Barber, J., McKeever, T. M., McDowell, S. E., Clayton, J. A., Ferner, R. E., Gordon, R. D., …Glover, M. (2015). A systematic review and meta-analysis of thiazide-induced hyponatraemia: time to reconsider electrolyte monitoring regimens after thiazide initiation?. British Journal of Clinical Pharmacology, 79(4), https://doi.org/10.1111/bcp.12499

Aims: Hyponatraemia is one of the major adverse effects of thiazide and thiazide-like diuretics and the leading cause of drug-induced hyponatraemia requiring hospital admission. We sought to review and analyze all published cases of this important co... Read More about A systematic review and meta-analysis of thiazide-induced hyponatraemia: time to reconsider electrolyte monitoring regimens after thiazide initiation?.

Exposure to point-of-sale displays and changes in susceptibility to smoking: findings from a cohort study of school students (2015)
Journal Article
Bogdanovica, I., Szatkowski, L., McNeill, A., Spanopoulos, D., & Britton, J. (2015). Exposure to point-of-sale displays and changes in susceptibility to smoking: findings from a cohort study of school students. Addiction, 110(4), https://doi.org/10.1111/add.12826

Aims To investigate the association between frequency of visiting shops and noticing of tobacco point-of-sale (PoS) displays and the development of susceptibility to smoking, or smoking uptake, in secondary school students. Design Two surveys... Read More about Exposure to point-of-sale displays and changes in susceptibility to smoking: findings from a cohort study of school students.

?-Glutamyltransferase, but not markers of hepatic fibrosis, is associated with cardiovascular disease in older people with type 2 diabetes mellitus: the Edinburgh Type 2 Diabetes Study (2015)
Journal Article
Morling, J. R., Fallowfield, J. A., Williamson, R. M., Robertson, C. M., Glancy, S., Guha, I. N., …Price, J. F. (2015). γ-Glutamyltransferase, but not markers of hepatic fibrosis, is associated with cardiovascular disease in older people with type 2 diabetes mellitus: the Edinburgh Type 2 Diabetes Study. Diabetologia, 58(7), 1484-1493. https://doi.org/10.1007/s00125-015-3575-y

© 2015, The Author(s). Aims/hypothesis: We examined the association of prevalent and incident cardiovascular disease (CVD) with chronic liver disease in a cohort of community-based people with type 2 diabetes, in order to clarify the relationship bet... Read More about ?-Glutamyltransferase, but not markers of hepatic fibrosis, is associated with cardiovascular disease in older people with type 2 diabetes mellitus: the Edinburgh Type 2 Diabetes Study.

Healthcare workers' willingness to work during an influenza pandemic: a systematic review and meta-analysis (2015)
Journal Article
Aoyagi, Y., Beck, C. R., Dingwall, R., & Nguyen-Van-Tam, J. (2015). Healthcare workers' willingness to work during an influenza pandemic: a systematic review and meta-analysis. Influenza and Other Respiratory Viruses, 9(3), 120-130. https://doi.org/10.1111/irv.12310

To estimate the proportion of healthcare workers (HCWs) willing to work during an influenza pandemic and identify associated risk factors, we undertook a systematic review and meta-analysis compliant with PRISMA guidance. Databases and grey literatur... Read More about Healthcare workers' willingness to work during an influenza pandemic: a systematic review and meta-analysis.

Maternal smoking and the risk of still birth: systematic review and meta-analysis (2015)
Journal Article
Marufu, T. C., Ahankari, A. S., Coleman, T., & Lewis, S. (in press). Maternal smoking and the risk of still birth: systematic review and meta-analysis. BMC Public Health, 15, Article 239. https://doi.org/10.1186/s12889-015-1552-5

BACKGROUND: Smoking in pregnancy is known to be associated with a range of adverse pregnancy outcomes, yet there is a high prevalence of smoking among pregnant women in many countries, and it remains a major public health concern. We have conducted a... Read More about Maternal smoking and the risk of still birth: systematic review and meta-analysis.