John P. Hutchinson
Global incidence and mortality of idiopathic pulmonary fibrosis: a systematic review
Hutchinson, John P.; Fogarty, Andrew W.; Hubbard, Richard B.; McKeever, Tricia M.
ANDREW FOGARTY email@example.com
Clinical Associate Professor & Reader in Clinical Epidemiology
RICHARD HUBBARD firstname.lastname@example.org
Blf/Gsk Professor of Epidemiological Resp Research
TRICIA MCKEEVER email@example.com
Professor of Epidemiology and Medical Statistics
Introduction: As idiopathic pulmonary fibrosis emerges as an important public health problem, there is a need to coordinate data on incidence and mortality globally. This study aims to systematically assess all available studies to investigate the global burden of disease.
Methods: Medline and Embase databases were searched systematically for all population-based studies of incidence or mortality of idiopathic pulmonary fibrosis. Clinical case series and prevalence studies were excluded. The search was supplemented using Google search engine, hand-searching of references and conference abstracts. Data were extracted independently by two authors using a pre-specified proforma, with assessment of methodological quality.
Results: 34 studies were identified providing data from 21 countries from 1968-2012. 28 studies reported incidence data, and eight reported mortality data. In studies from year 2000 onwards, we estimated a conservative incidence range of 3-9 cases per 100,000 per year for Europe and North America. Incidence was lower in East Asia and South America. The majority of studies showed an increase in incidence over time.
Conclusions: The incidence of idiopathic pulmonary fibrosis is increasing worldwide, and rates are coming together across countries. Current data suggest incidence is similar to that of conditions such as stomach, liver, testicular and cervical cancers.
Hutchinson, J. P., Fogarty, A. W., Hubbard, R. B., & McKeever, T. M. (2015). Global incidence and mortality of idiopathic pulmonary fibrosis: a systematic review. European Respiratory Journal, 46(3), doi:10.1183/09031936.00185114
|Journal Article Type||Article|
|Publication Date||May 14, 2015|
|Deposit Date||Feb 12, 2016|
|Publicly Available Date||Feb 12, 2016|
|Journal||European Respiratory Journal|
|Publisher||European Respiratory Society|
|Peer Reviewed||Peer Reviewed|
|Keywords||idiopathic pulmonary fibrosis, incidence, mortality|
|Copyright Statement||Copyright information regarding this work can be found at the following address: http://eprints.nottingham.ac.uk/end_user_agreement.pdf|
|Additional Information||This is an author-submitted, peer-reviewed version of a manuscript that has been accepted for publication in the European Respiratory Journal, prior to copy-editing, formatting and typesetting. This version of the manuscript may not be duplicated or reproduced without prior permission from the copyright owner, the European Respiratory Society. The publisher is not responsible or liable for any errors or omissions in this version of the manuscript or in any version derived from it by any other parties. The final, copy-edited, published article, which is the version of record, is available without a subscription 18 months after the date of issue publication.|
Hutchinson - global incidence and mortality of IPF - 2015.pdf
Copyright information regarding this work can be found at the following address: http://eprints.nottingham.ac.uk/end_user_agreement.pdf
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