Srinivasarao Ravipati
Plasma lipid biomarker signatures in squamous carcinoma and adenocarcinoma lung cancer patients
Ravipati, Srinivasarao; Baldwin, David R.; Barr, Helen L.; Fogarty, Andrew W.; Barrett, David A.
Authors
David R. Baldwin
Helen L. Barr
ANDREW FOGARTY ANDREW.FOGARTY@NOTTINGHAM.AC.UK
Clinical Associate Professor & Reader in Clinical Epidemiology
David A. Barrett
Abstract
There is a clinical need for reliable biomarkers for lung cancer that permit early diagnosis of the disease and provide prediction of histological phenotype. A prospective study design was used with a study population of patients with suspected lung cancer. Blood samples were collected from 17 patients with histologically confirmed squamous cell lung carcinoma, 17 individuals with adenocarcinoma, and 17 control individuals who did not subsequently have a diagnosis of lung cancer or any other cancer. Blood plasma samples were analysed for their lipid profiles using liquid chromatography coupled with high resolution mass spectrometry. Data were analysed using multivariate statistical methods. There was good separation between histological subtypes and control groups and also between individuals with a subsequent diagnosis of adenocarcinoma and squamous cell carcinoma (sensitivity 80 %, specificity 83 %, Q2 = 0.70). Alterations in the levels of different classes of lipids including triglycerides (TGs), phosphatidylinositols (PIs), phosphatidylcholines (PCs), phosphatidylethanolamines (PEs), free fatty acids, lysophospholipids and sphingolipids were observed in squamous carcinoma and adenocarcinoma lung cancer patients when compared with control patients. In conclusion, this study has identified candidate lipid biomarkers of non-small cell lung cancer patients which may be helpful to indicate the tumour subtype and to differentiate them from patients who do not have lung cancer. Measuring these biomarkers has the potential to improve diagnosis in patients with suspected lung cancer and risk stratification in screening.
Citation
Ravipati, S., Baldwin, D. R., Barr, H. L., Fogarty, A. W., & Barrett, D. A. (in press). Plasma lipid biomarker signatures in squamous carcinoma and adenocarcinoma lung cancer patients. Metabolomics, 11(6), https://doi.org/10.1007/s11306-015-0811-x
Journal Article Type | Article |
---|---|
Acceptance Date | May 19, 2015 |
Online Publication Date | May 26, 2015 |
Deposit Date | Nov 22, 2016 |
Publicly Available Date | Nov 22, 2016 |
Journal | Metabolomics |
Electronic ISSN | 1573-3890 |
Publisher | Springer Verlag |
Peer Reviewed | Peer Reviewed |
Volume | 11 |
Issue | 6 |
DOI | https://doi.org/10.1007/s11306-015-0811-x |
Keywords | lung cancer, squamous carcinoma, adenocarcinoma, lipidomics |
Public URL | https://nottingham-repository.worktribe.com/output/751329 |
Publisher URL | http://link.springer.com/article/10.1007%2Fs11306-015-0811-x |
Additional Information | The final publication is available at Springer via http://dx.doi.org/10.1007/s11306-015-0811-x |
Contract Date | Nov 22, 2016 |
Files
Lung cancer paper2015 FINAL clean.pdf
(6 Mb)
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