Insa Feinkohl
Cardiovascular risk factors and cognitive decline in older people with type 2 diabetes
Feinkohl, Insa; Keller, Mark�ta; Robertson, Christine M.; Morling, Joanne R.; McLachlan, Stela; Frier, Brian M.; Deary, Ian J.; Strachan, Mark W.J.; Price, Jackie F.
Authors
Mark�ta Keller
Christine M. Robertson
JOANNE MORLING JOANNE.MORLING@NOTTINGHAM.AC.UK
Clinical Associate Professor
Stela McLachlan
Brian M. Frier
Ian J. Deary
Mark W.J. Strachan
Jackie F. Price
Abstract
AIMS/HYPOTHESIS: The aim of this work was to assess the role of well-established cardiovascular risk factors in the late-life cognitive decline of patients with type 2 diabetes.
METHODS: Data from 831 participants (aged 60-75 years) attending the 4 year follow-up of the Edinburgh Type 2 Diabetes Study (ET2DS) were used. Smoking history (pack-years), BP, HbA1c, plasma glucose and cholesterol were determined at baseline clinics (single time measurements) and/or from serial data recorded on a clinical management database from diagnosis until recruitment ('historical' data). Principal component analysis derived a factor, g, of general ability from seven cognitive tests. Linear regression models of follow-up g were adjusted for baseline g to represent 4 year cognitive change. 'Accelerated late-life cognitive decline' was defined as scoring in the lowest tertile of '4 year cognitive change' regression scores. Analyses controlled for age and sex.
RESULTS: A baseline history of moderate/heavy smoking (>/= 10 pack-years) and a 1% increased historical HbA1c (equivalent to an increase by 11 mmol/mol) predicted a 64% (OR 1.64; 95% CI 1.14, 2.34; p = 0.007) and 21% (OR 1.21; 95% CI 1.00, 1.45; p = 0.046) increased risk of accelerated cognitive decline, respectively. When treated as continuous measures, higher pack-years, historical HbA1c and historical BP emerged as significant independent predictors of 4 year decline in g (standardised beta range -0.07 to -0.14; all p
Citation
Feinkohl, I., Keller, M., Robertson, C. M., Morling, J. R., McLachlan, S., Frier, B. M., …Price, J. F. (2015). Cardiovascular risk factors and cognitive decline in older people with type 2 diabetes. Diabetologia, 58(7), https://doi.org/10.1007/s00125-015-3581-0
Journal Article Type | Article |
---|---|
Acceptance Date | Mar 16, 2015 |
Online Publication Date | Apr 7, 2015 |
Publication Date | Jul 31, 2015 |
Deposit Date | Apr 27, 2018 |
Publicly Available Date | Apr 27, 2018 |
Journal | Diabetologia |
Print ISSN | 0012-186X |
Electronic ISSN | 1432-0428 |
Publisher | Springer Verlag |
Peer Reviewed | Peer Reviewed |
Volume | 58 |
Issue | 7 |
DOI | https://doi.org/10.1007/s00125-015-3581-0 |
Keywords | Blood glucose; Blood pressure; Cardiovascular risk ; Cholesterol; Cognitive impairment ; Glycaemic control; Hyperglycaemia; Older age; Smoking ; Type 2 diabetes |
Public URL | https://nottingham-repository.worktribe.com/output/755845 |
Publisher URL | https://link.springer.com/article/10.1007%2Fs00125-015-3581-0 |
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Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0
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