All Outputs (91)

Phenotypic change and induction of cytokeratin expression during in vitro culture of corneal stromal cells (2015)
Journal Article

Purpose: Cells of the corneal epithelium and stroma can be distinguished in vivo by different intermediate filaments, cytokeratins for corneal epithelial cells (CEC) and vimentin for keratocytes. Isolated and cultured keratocytes change phenotype, lo... Read More about Phenotypic change and induction of cytokeratin expression during in vitro culture of corneal stromal cells.

Preventive acetaminophen reduces postoperative opioid consumption, vomiting, and pain scores after surgery: systematic review and meta-analysis (2015)
Journal Article

Background and Objectives: Preventive analgesia has been proposed as a potential strategy to reduce postoperative pain. However, there is currently no review that focuses on acetaminophen for preventive analgesia. Methods: We conducted a search of... Read More about Preventive acetaminophen reduces postoperative opioid consumption, vomiting, and pain scores after surgery: systematic review and meta-analysis.

Cardiomyocytes from human pluripotent stem cells: from laboratory curiosity to industrial biomedical platform (2015)
Journal Article

Cardiomyocytes from human pluripotent stem cells (hPSCs-CMs) could revolutionise biomedicine. Global burden of heart failure will soon reach USD $90bn, while unexpected cardiotoxicity underlies 28% of drug withdrawals. Advances in hPSC isolation, Cas... Read More about Cardiomyocytes from human pluripotent stem cells: from laboratory curiosity to industrial biomedical platform.

Investigating lung responses with functional hyperpolarized xenon-129 MRI in an ex vivo rat model of asthma (2015)
Journal Article

© 2015 The Authors. Wiley Periodicals, Inc. Purpose: Asthma is a disease of increasing worldwide importance that calls for new investigative methods. Ex vivo lung tissue is being increasingly used to study functional respiratory parameters independen... Read More about Investigating lung responses with functional hyperpolarized xenon-129 MRI in an ex vivo rat model of asthma.

Measuring macroscopic brain connections in vivo (2015)
Journal Article

Decades of detailed anatomical tracer studies in non-human animals point to a rich and complex organization of long-range white matter connections in the brain. State-of-the art in vivo imaging techniques are striving to achieve a similar level of de... Read More about Measuring macroscopic brain connections in vivo.

Nottingham Prognostic Index Plus: validation of a clinical decision making tool in breast cancer in an independent series (2015)
Journal Article

The Nottingham Prognostic Index Plus (NPI+)is a clinical decision making tool in breast cancer (BC) that aims to provide improved patient outcome stratification superior to the traditional NPI. This study aimed to validate the NPI+ in an independent... Read More about Nottingham Prognostic Index Plus: validation of a clinical decision making tool in breast cancer in an independent series.

How does auditory training work? Joined up thinking and listening (2015)
Journal Article

Auditory training aims to compensate for degradation in the auditory signal and is offered as an intervention to help alleviate the most common complaint in people with hearing loss, understanding speech in a background noise. Yet there remain many u... Read More about How does auditory training work? Joined up thinking and listening.

An integrated approach to correction for off-resonance effects and subject movement in diffusion MR imaging (2015)
Journal Article

In this paper we describe a method for retrospective estimation and correction of eddy current (EC)-induced distortions and subject movement in diffusion imaging. In addition a susceptibility-induced field can be supplied and will be incorporated int... Read More about An integrated approach to correction for off-resonance effects and subject movement in diffusion MR imaging.

The feasibility of psychomotor therapy in acute mental health services for adults with intellectual disability (2015)
Journal Article

Background. Psychomotor therapy enables people to reflect on the relationship between experiences and feelings by starting from awareness of bodily responses rather than from awareness of emotion. In this study we examine PsyMot (ID), an assessment t... Read More about The feasibility of psychomotor therapy in acute mental health services for adults with intellectual disability.

Hyperacusis Questionnaire as a Tool for Measuring Hypersensitivity to Sound in a Tinnitus Research Population (2015)
Journal Article

Hypersensitivity to external sounds is often comorbid with tinnitus and may be significant for adherence to certain types of tinnitus management. Therefore, a clear measure of sensitivity to sound is important. The aim of this study was to evaluate t... Read More about Hyperacusis Questionnaire as a Tool for Measuring Hypersensitivity to Sound in a Tinnitus Research Population.

Recommendations to facilitate the ideal fit note: are they achievable in practice? (2015)
Journal Article

Background: Although the UK fit note has been broadly welcomed as a tool to facilitate return to work, difficulties and uncertainties have resulted in wide variation in its use. Agreement on what constitutes the ‘ideal’ fit note from the perspective... Read More about Recommendations to facilitate the ideal fit note: are they achievable in practice?.

Identification of mechano-sensitive C fibre sensitization and contribution to nerve injury-induced mechanical hyperalgesia (2015)
Journal Article

Background C fibre hyperexcitability is fundamental to chronic pain development in humans and rodents; therefore, peripheral sensory neuronal sensitization plays a role in the development of mechanical hyperalgesia. However, the axonal properties... Read More about Identification of mechano-sensitive C fibre sensitization and contribution to nerve injury-induced mechanical hyperalgesia.

Building analytic skills to drive improvements in patient care and organisational decision making: an information analysts’ development programme (2015)
Journal Article

Purpose This paper briefly outlines a development programme designed to improve the skills of NHS Information Analysts and assesses the extent these skills have been developed. There are significant opportunities for the NHS to utilise information... Read More about Building analytic skills to drive improvements in patient care and organisational decision making: an information analysts’ development programme.

Psychometric properties of the Tinnitus Functional Index (TFI): assessment in a UK research volunteer population (2015)
Journal Article

Objectives Questionnaires are essential for measuring tinnitus severity and intervention-related change but there is no standard instrument used routinely in research settings. Most tinnitus questionnaires are optimised for measuring severity but... Read More about Psychometric properties of the Tinnitus Functional Index (TFI): assessment in a UK research volunteer population.

The burden of severe asthma in childhood and adolescence: Results from the paediatric U-BIOPRED cohorts (2015)
Journal Article

U-BIOPRED aims to characterise paediatric and adult severe asthma using conventional and innovative systems biology approaches. A total of 99 school-age children with severe asthma and 81 preschoolers with severe wheeze were compared with 49 schoo... Read More about The burden of severe asthma in childhood and adolescence: Results from the paediatric U-BIOPRED cohorts.

A probabilistic atlas of the cerebellar white matter (2015)
Journal Article

Imaging of the cerebellar cortex, deep cerebellar nuclei and their connectivity are gaining attraction, due to the important role the cerebellum plays in cognition and motor control. Atlases of the cerebellar cortex and nuclei are used to locate regi... Read More about A probabilistic atlas of the cerebellar white matter.

Computer and internet interventions to optimize listening and learning for people with hearing loss: accessibility, use, and adherence (2015)
Journal Article

Purpose: The aim of this research forum article was to examine accessibility, use, and adherence to computerized and online interventions for people with hearing loss. Method: Four intervention studies of people with hearing loss were examined: 2 aud... Read More about Computer and internet interventions to optimize listening and learning for people with hearing loss: accessibility, use, and adherence.

A systematic review and meta-regression analysis of prophylactic gabapentin for postoperative pain (2015)
Journal Article

We searched MEDLINE, Embase, CINAHL, AMED and CENTRAL databases until December 2014 and included 133 randomised controlled trials of peri-operative gabapentin vs placebo. Gabapentin reduced mean (95% CI) 24-h morphine-equivalent consumption by 8.44 (... Read More about A systematic review and meta-regression analysis of prophylactic gabapentin for postoperative pain.

Use of Mobile Clinical Decision Support Software by Junior Doctors at a UK Teaching Hospital: Identification and Evaluation of Barriers to Engagement (2015)
Journal Article

Intrinsic and extrinsic motivation is associated with computer-based auditory training uptake, engagement, and adherence for people with hearing loss (2015)
Journal Article

Hearing aid intervention typically occurs after significant delay, or not at all, resulting in an unmet need for many people with hearing loss. Computer-based auditory training (CBAT) may provide generalized benefits to real-world listening, particul... Read More about Intrinsic and extrinsic motivation is associated with computer-based auditory training uptake, engagement, and adherence for people with hearing loss.