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The burden of severe asthma in childhood and adolescence: Results from the paediatric U-BIOPRED cohorts

Fleming, Louise; Murray, Clare; Bansal, Aruna T.; Hashimoto, Simone; Bisgaard, Hans; Bush, Andrew; Frey, Urs; Hedlin, Gunilla; Singer, Florian; Aalderen, Wim M. van; Vissing, Nadja H.; Zolkipli, Zaraquiza; Selby, Anna; Fowler, Stephen; Shaw, Dominick E.; Chung, Kian Fan; Sousa, Ana R.; Wagers, Scott; Corfield, Julie; Pandis, Ioannis; Rowe, Anthony; Formaggio, Elena; Sterk, Peter J.; Roberts, Graham


Louise Fleming

Clare Murray

Aruna T. Bansal

Simone Hashimoto

Hans Bisgaard

Andrew Bush

Urs Frey

Gunilla Hedlin

Florian Singer

Wim M. van Aalderen

Nadja H. Vissing

Zaraquiza Zolkipli

Anna Selby

Stephen Fowler

Kian Fan Chung

Ana R. Sousa

Scott Wagers

Julie Corfield

Ioannis Pandis

Anthony Rowe

Elena Formaggio

Peter J. Sterk

Graham Roberts


U-BIOPRED aims to characterise paediatric and adult severe asthma using conventional and innovative systems biology approaches.

A total of 99 school-age children with severe asthma and 81 preschoolers with severe wheeze were compared with 49 school-age children with mild/moderate asthma and 53 preschoolers with mild/moderate wheeze in a cross-sectional study.

Despite high-dose treatment, the severe cohorts had more severe exacerbations compared with the mild/moderate ones (annual medians: school-aged 3.0 versus 1.1, preschool 3.9 versus 1.8; p


Fleming, L., Murray, C., Bansal, A. T., Hashimoto, S., Bisgaard, H., Bush, A., …Roberts, G. (2015). The burden of severe asthma in childhood and adolescence: Results from the paediatric U-BIOPRED cohorts. European Respiratory Journal, 46(5), doi:10.1183/13993003.00780-2015

Journal Article Type Article
Acceptance Date Aug 23, 2015
Online Publication Date Sep 24, 2015
Publication Date Nov 1, 2015
Deposit Date May 9, 2017
Journal European Respiratory Journal
Print ISSN 0903-1936
Electronic ISSN 1399-3003
Publisher European Respiratory Society
Peer Reviewed Peer Reviewed
Volume 46
Issue 5
Public URL
Publisher URL