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Measuring macroscopic brain connections in vivo

Jbabdi, Saad; Sotiropoulos, Stamatios N.; Haber, Suzanne N.; Van Essen, David C.; Behrens, Timothy E.

Authors

Saad Jbabdi

Stamatios N. Sotiropoulos

Suzanne N. Haber

David C. Van Essen

Timothy E. Behrens



Abstract

Decades of detailed anatomical tracer studies in non-human animals point to a rich and complex organization of long-range white matter connections in the brain. State-of-the art in vivo imaging techniques are striving to achieve a similar level of detail in humans, but multiple technical factors can limit their sensitivity and fidelity. In this review, we mostly focus on magnetic resonance imaging of the brain. We highlight some of the key challenges in analyzing and interpreting in vivo connectomics data, particularly in relation to what is known from classical neuroanatomy in laboratory animals. We further illustrate that, despite the challenges, in vivo imaging methods can be very powerful and provide information on connections that is not available by any other means.

Journal Article Type Article
Publication Date Oct 27, 2015
Journal Nature Neuroscience
Print ISSN 1097-6256
Electronic ISSN 1546-1726
Publisher Nature Publishing Group
Peer Reviewed Peer Reviewed
Volume 18
Issue 11
APA6 Citation Jbabdi, S., Sotiropoulos, S. N., Haber, S. N., Van Essen, D. C., & Behrens, T. E. (2015). Measuring macroscopic brain connections in vivo. Nature Neuroscience, 18(11), https://doi.org/10.1038/nn.4134
DOI https://doi.org/10.1038/nn.4134
Publisher URL https://www.nature.com/articles/nn.4134
Copyright Statement Copyright information regarding this work can be found at the following address: http://eprints.nottingh.../end_user_agreement.pdf

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://eprints.nottingham.ac.uk/end_user_agreement.pdf





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