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Measuring macroscopic brain connections in vivo

Jbabdi, Saad; Sotiropoulos, Stamatios N.; Haber, Suzanne N.; Van Essen, David C.; Behrens, Timothy E.

Authors

Saad Jbabdi

Stamatios N. Sotiropoulos

Suzanne N. Haber

David C. Van Essen

Timothy E. Behrens



Abstract

Decades of detailed anatomical tracer studies in non-human animals point to a rich and complex organization of long-range white matter connections in the brain. State-of-the art in vivo imaging techniques are striving to achieve a similar level of detail in humans, but multiple technical factors can limit their sensitivity and fidelity. In this review, we mostly focus on magnetic resonance imaging of the brain. We highlight some of the key challenges in analyzing and interpreting in vivo connectomics data, particularly in relation to what is known from classical neuroanatomy in laboratory animals. We further illustrate that, despite the challenges, in vivo imaging methods can be very powerful and provide information on connections that is not available by any other means.

Citation

Jbabdi, S., Sotiropoulos, S. N., Haber, S. N., Van Essen, D. C., & Behrens, T. E. (2015). Measuring macroscopic brain connections in vivo. Nature Neuroscience, 18(11), https://doi.org/10.1038/nn.4134

Journal Article Type Article
Acceptance Date Sep 8, 2015
Publication Date Oct 27, 2015
Deposit Date Apr 5, 2018
Publicly Available Date Mar 29, 2024
Journal Nature Neuroscience
Print ISSN 1097-6256
Electronic ISSN 1546-1726
Publisher Nature Publishing Group
Peer Reviewed Peer Reviewed
Volume 18
Issue 11
DOI https://doi.org/10.1038/nn.4134
Public URL https://nottingham-repository.worktribe.com/output/763152
Publisher URL https://www.nature.com/articles/nn.4134

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