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Concurrent mapping of brain ontogeny and phylogeny within a common space: standardised tractography and applications

Warrington, Shaun; Thompson, Elinor; Bastiani, Matteo; Dubois, Jessica; Baxter, Luke; Slater, Rebeccah; Jbabdi, Saad; Mars, Rogier B.; Sotiropoulos, Stamatios N.


Elinor Thompson

Matteo Bastiani

Jessica Dubois

Luke Baxter

Rebeccah Slater

Saad Jbabdi

Rogier B. Mars


Developmental and evolutionary effects on brain organization are complex, yet linked, as evidenced by the correspondence in cortical area expansion across these vastly different time scales. However, it is still not possible to study concurrently the ontogeny and phylogeny of cortical areal connections, which is arguably more relevant to brain function than allometric measurements. Here, we propose a novel framework that allows the integration of structural connectivity maps from humans (adults and neonates) and nonhuman primates (macaques) onto a common space. We use white matter bundles to anchor the common space and use the uniqueness of cortical connection patterns to these bundles to probe area specialization. This enabled us to quantitatively study divergences and similarities in connectivity over evolutionary and developmental scales, to reveal brain maturation trajectories, including the effect of premature birth, and to translate cortical atlases between diverse brains. Our findings open new avenues for an integrative approach to imaging neuroanatomy.


Warrington, S., Thompson, E., Bastiani, M., Dubois, J., Baxter, L., Slater, R., …Sotiropoulos, S. N. (2022). Concurrent mapping of brain ontogeny and phylogeny within a common space: standardised tractography and applications. Science Advances, 8(42), Article eabq2.

Journal Article Type Article
Acceptance Date Aug 25, 2022
Online Publication Date Oct 19, 2022
Publication Date Oct 21, 2022
Deposit Date Sep 7, 2022
Publicly Available Date Sep 7, 2022
Journal Science Advances
Electronic ISSN 2375-2548
Publisher American Association for the Advancement of Science
Peer Reviewed Peer Reviewed
Volume 8
Issue 42
Article Number eabq2
Public URL
Publisher URL


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