Dr SHAUN WARRINGTON Shaun.Warrington1@nottingham.ac.uk
Research Fellow
Concurrent mapping of brain ontogeny and phylogeny within a common space: standardised tractography and applications
Warrington, Shaun; Thompson, Elinor; Bastiani, Matteo; Dubois, Jessica; Baxter, Luke; Slater, Rebeccah; Jbabdi, Saad; Mars, Rogier B.; Sotiropoulos, Stamatios N.
Authors
Elinor Thompson
Matteo Bastiani
Jessica Dubois
Luke Baxter
Rebeccah Slater
Saad Jbabdi
Rogier B. Mars
STAMATIOS SOTIROPOULOS STAMATIOS.SOTIROPOULOS@NOTTINGHAM.AC.UK
Professor of Computational Neuroimaging
Abstract
Developmental and evolutionary effects on brain organization are complex, yet linked, as evidenced by the correspondence in cortical area expansion across these vastly different time scales. However, it is still not possible to study concurrently the ontogeny and phylogeny of cortical areal connections, which is arguably more relevant to brain function than allometric measurements. Here, we propose a novel framework that allows the integration of structural connectivity maps from humans (adults and neonates) and nonhuman primates (macaques) onto a common space. We use white matter bundles to anchor the common space and use the uniqueness of cortical connection patterns to these bundles to probe area specialization. This enabled us to quantitatively study divergences and similarities in connectivity over evolutionary and developmental scales, to reveal brain maturation trajectories, including the effect of premature birth, and to translate cortical atlases between diverse brains. Our findings open new avenues for an integrative approach to imaging neuroanatomy.
Citation
Warrington, S., Thompson, E., Bastiani, M., Dubois, J., Baxter, L., Slater, R., …Sotiropoulos, S. N. (2022). Concurrent mapping of brain ontogeny and phylogeny within a common space: standardised tractography and applications. Science Advances, 8(42), Article eabq2. https://doi.org/10.1126/sciadv.abq2022
Journal Article Type | Article |
---|---|
Acceptance Date | Aug 25, 2022 |
Online Publication Date | Oct 19, 2022 |
Publication Date | Oct 21, 2022 |
Deposit Date | Sep 7, 2022 |
Publicly Available Date | Sep 7, 2022 |
Journal | Science Advances |
Electronic ISSN | 2375-2548 |
Peer Reviewed | Peer Reviewed |
Volume | 8 |
Issue | 42 |
Article Number | eabq2 |
DOI | https://doi.org/10.1126/sciadv.abq2022 |
Public URL | https://nottingham-repository.worktribe.com/output/10913578 |
Publisher URL | https://www.science.org/doi/10.1126/sciadv.abq2022 |
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Concurrent mapping of brain ontogeny and phylogeny within a common space: Standardized tractography and applications
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Publisher Licence URL
https://creativecommons.org/licenses/by/4.0/
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