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Preventive acetaminophen reduces postoperative opioid consumption, vomiting, and pain scores after surgery: systematic review and meta-analysis

Doleman, Brett; Read, David; Lund, Jonathan N.; Williams, John P.

Authors

Brett Doleman

David Read

Jonathan N. Lund

John P. Williams



Abstract

Background and Objectives: Preventive analgesia has been proposed as a potential strategy to reduce postoperative pain. However, there is currently no review that focuses on acetaminophen for preventive analgesia.

Methods: We conducted a search of MEDLINE, EMBASE, Cinahl, AMED, and CENTRAL databases identifying randomized controlled trials that compared preventive acetaminophen with postincision acetaminophen.

Results: Seven studies with 544 participants were included. Overall, the studies showed a reduction in 24-hour opioid consumption (standardized mean difference [SMD] of -0.52; 95% confidence interval [95% CI], -0.98 to -0.06), lower pain scores at 1 hour (MD, -0.50; 95% CI, -0.98 to -0.02) and 2 hours (MD, -0.34; 95% CI, -0.67 to -0.01), and a lower incidence of postoperative vomiting (risk ratio, 0.50; 95% CI, 0.31-0.83) in the preventive acetaminophen group. Current studies are limited by a potential risk of bias.

Conclusions: To our knowledge, this is the first review to describe a potential preventive effect of acetaminophen. However, well-conducted randomized controlled trials are necessary to substantiate the conclusions of this review.

Journal Article Type Article
Publication Date Nov 1, 2015
Journal Regional Anesthesia and Pain Medicine
Print ISSN 1098-7339
Electronic ISSN 1532-8651
Publisher Lippincott, Williams & Wilkins
Peer Reviewed Peer Reviewed
Volume 40
Issue 6
APA6 Citation Doleman, B., Read, D., Lund, J. N., & Williams, J. P. (2015). Preventive acetaminophen reduces postoperative opioid consumption, vomiting, and pain scores after surgery: systematic review and meta-analysis. Regional Anesthesia and Pain Medicine, 40(6), https://doi.org/10.1097/AAP.0000000000000311
DOI https://doi.org/10.1097/AAP.0000000000000311
Publisher URL http://journals.lww.com/rapm/pages/articleviewer.aspx?year=2015&issue=11000&article=00008&type=abstract
Copyright Statement Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by-nc/4.0

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by-nc/4.0





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