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Naturally Occurring Mutations in the PA Gene Are Key Contributors to Increased Virulence of Pandemic H1N1/09 Influenza Virus in Mice (2014)
Journal Article
Sun, Y., Xu, Q., Shen, Y., Liu, L., Wei, K., Sun, H., …Liu, J. (2014). Naturally Occurring Mutations in the PA Gene Are Key Contributors to Increased Virulence of Pandemic H1N1/09 Influenza Virus in Mice. Journal of Virology, 88(8), 4600-4604. https://doi.org/10.1128/jvi.03158-13

We examined the molecular basis of virulence of pandemic H1N1/09 influenza viruses by reverse genetics based on two H1N1/09 virus isolates (A/California/04/2009 [CA04] and A/swine/Shandong/731/2009 [SD731]) with contrasting pathogenicities in mice. W... Read More about Naturally Occurring Mutations in the PA Gene Are Key Contributors to Increased Virulence of Pandemic H1N1/09 Influenza Virus in Mice.

Molecular Characterization of Adipose Tissue in the African Elephant (Loxodonta africana) (2014)
Journal Article
Nilsson, E. M., Fainberg, H. P., Choong, S. S., Giles, T. C., Sells, J., May, S., …Yon, L. (2014). Molecular Characterization of Adipose Tissue in the African Elephant (Loxodonta africana). PLoS ONE, 9(3), Article e91717. https://doi.org/10.1371/journal.pone.0091717

Adipose tissue (AT) is a dynamic and flexible organ with regulatory roles in physiological functions including metabolism, reproduction and inflammation; secreted adipokines, including leptin, and fatty acids facilitate many of these roles. The Afric... Read More about Molecular Characterization of Adipose Tissue in the African Elephant (Loxodonta africana).

Pigs naturally exposed to porcine circovirus type 2 (PCV2) generate antibody responses capable to neutralise PCV2 isolates of different genotypes and geographic origins (2014)
Journal Article
Kurtz, S., Grau-Roma, L., Cortey, M., Fort, M., Rodríguez, F., Sibila, M., & Segalés, J. (2014). Pigs naturally exposed to porcine circovirus type 2 (PCV2) generate antibody responses capable to neutralise PCV2 isolates of different genotypes and geographic origins. Veterinary Research, 45, Article 29. https://doi.org/10.1186/1297-9716-45-29

Porcine circovirus type 2 (PCV2) is the essential infectious agent for PCV2-systemic disease (PCV2-SD, formerly known as postweaning multisystemic wasting syndrome) and other pathological conditions. Recent studies indicated antigenic variability am... Read More about Pigs naturally exposed to porcine circovirus type 2 (PCV2) generate antibody responses capable to neutralise PCV2 isolates of different genotypes and geographic origins.

Novel gonadal characteristics in an aged bovine freemartin (2014)
Journal Article
Remnant, J., Lea, R. G., Allen, C. E., Huxley, J., Robinson, R. S., & Brower, A. (2014). Novel gonadal characteristics in an aged bovine freemartin. Animal Reproduction Science, 146(1-2), https://doi.org/10.1016/j.anireprosci.2014.02.011

The gonads from a five year old freemartin Holstein animal were subjected to morphological analysis and to immunohistochemistry using antibodies against developmental and functional markers. We demonstrate, for the first time, the retention of anti-m... Read More about Novel gonadal characteristics in an aged bovine freemartin.

Novel ovine polymorphisms and adaptive evolution in mammalian TLR2 suggest existence of multiple pathogen binding regions (2014)
Journal Article
Haig, D., Smith, S., & Emes, R. (2014). Novel ovine polymorphisms and adaptive evolution in mammalian TLR2 suggest existence of multiple pathogen binding regions. Gene, 540(2), 217-225. https://doi.org/10.1016/j.gene.2014.02.032

Toll-like receptors initiate inflammatory responses following the recognition of a wide repertoire of pathogens including bacteria, fungi, protozoa and viruses. They are composed of an extracellular leucine-rich repeat domain responsible for detectin... Read More about Novel ovine polymorphisms and adaptive evolution in mammalian TLR2 suggest existence of multiple pathogen binding regions.

Targeted NGS gene panel identifies mutations in RSPH1 causing primary ciliary dyskinesia and a common mechanism for ciliary central pair agenesis due to radial spoke defects (2014)
Journal Article
Onoufriadis, A., Shoemark, A., Schmidts, M., Patel, M., Jimenez, G., Liu, H., …Mitchison, H. M. (2014). Targeted NGS gene panel identifies mutations in RSPH1 causing primary ciliary dyskinesia and a common mechanism for ciliary central pair agenesis due to radial spoke defects. Human Molecular Genetics, 23(13), 3362-3374. https://doi.org/10.1093/hmg/ddu046

Primary ciliary dyskinesia (PCD) is an inherited chronic respiratory obstructive disease with randomized body laterality and infertility, resulting from cilia and sperm dysmotility. PCD is characterized by clinical variability and extensive genetic h... Read More about Targeted NGS gene panel identifies mutations in RSPH1 causing primary ciliary dyskinesia and a common mechanism for ciliary central pair agenesis due to radial spoke defects.

Discovery of AZD3199, An Inhaled Ultralong Acting ?2 Receptor Agonist with Rapid Onset of Action (2014)
Journal Article
Stocks, M., Alcaraz, L., Bailey, A., Bonnert, R., Cadogan, E., Christie, J., …Young, A. (2014). Discovery of AZD3199, An Inhaled Ultralong Acting β2 Receptor Agonist with Rapid Onset of Action. ACS Medicinal Chemistry Letters, 5(4), 416-421. https://doi.org/10.1021/ml4005232

A series of dibasic des-hydroxy ?2 receptor agonists has been prepared and evaluated for potential as inhaled ultra-long acting bronchodilators. Determination of activities at the human ?-adrenoreceptors demonstrated a series of highly potent and se... Read More about Discovery of AZD3199, An Inhaled Ultralong Acting ?2 Receptor Agonist with Rapid Onset of Action.

Recombinant plants provide a new approach to the production of bacterial polysaccharide for vaccines (2014)
Journal Article
Smith, C. M., Fry, S. C., Gough, K. C., Patel, A. J., Glenn, S., Goldrick, M., …Andrew, P. W. (2014). Recombinant plants provide a new approach to the production of bacterial polysaccharide for vaccines. PLoS ONE, 9(2), Article e88144. https://doi.org/10.1371/journal.pone.0088144

Bacterial polysaccharides have numerous clinical or industrial uses. Recombinant plants could offer the possibility of producing bacterial polysaccharides on a large scale and free of contaminating bacterial toxins and antigens. We investigated the f... Read More about Recombinant plants provide a new approach to the production of bacterial polysaccharide for vaccines.

Effects of cyclic equibiaxial mechanical stretch on ?-BK and TRPV4 expression in equine chondrocytes (2014)
Journal Article
Hdud, I. M., Mobasheri, A., & Loughna, P. (2014). Effects of cyclic equibiaxial mechanical stretch on ?-BK and TRPV4 expression in equine chondrocytes. SpringerPlus, 3, Article 59. https://doi.org/10.1186/2193-1801-3-59

Background Chondrocytes are regularly exposed to load-induced stimuli and have the capability to sense and respond to applied mechanical stress. However, the mechanisms involved in chondrocyte mechanotransduction are not clearly understood. The pu... Read More about Effects of cyclic equibiaxial mechanical stretch on ?-BK and TRPV4 expression in equine chondrocytes.

Acinar cell carcinoma of exocrine pancreas in two horses (2014)
Journal Article
de Brot, S., Junge, H., & Hilbe, M. (2014). Acinar cell carcinoma of exocrine pancreas in two horses. Journal of Comparative Pathology, 150(4), https://doi.org/10.1016/j.jcpa.2014.01.003

Two horses were presented with non-specific clinical signs of several weeks' duration and were humanely destroyed due to a poor prognosis. At necropsy examination, both horses had multiple small, white nodules replacing pancreatic tissue and involvin... Read More about Acinar cell carcinoma of exocrine pancreas in two horses.

Bayesian evaluation of budgets for endemic disease control: an example using management changes to reduce milksomatic cell count early in the first lactation of Irish dairy cows (2014)
Journal Article
Archer, S. C., Mc Coy, F., Wapenaar, W., & Green, M. J. (2014). Bayesian evaluation of budgets for endemic disease control: an example using management changes to reduce milksomatic cell count early in the first lactation of Irish dairy cows. Preventive Veterinary Medicine, 113(1), https://doi.org/10.1016/j.prevetmed.2013.10.011

The aim of this research was to determine budgets for specific management interventions to control heifer mastitis in Irish dairy herds as an example of evidence synthesis and 1-step Bayesian micro-simulation in a veterinary context. Budgets were det... Read More about Bayesian evaluation of budgets for endemic disease control: an example using management changes to reduce milksomatic cell count early in the first lactation of Irish dairy cows.

Association between somatic cell count during the first lactation and the cumulative milk yield of cows in Irish dairy herds (2014)
Journal Article
Archer, S. C., Mc Coy, F., Wapenaar, W., & Green, M. J. (2014). Association between somatic cell count during the first lactation and the cumulative milk yield of cows in Irish dairy herds. Journal of Dairy Science, 97(4), https://doi.org/10.3168/jds.2013-7158

Reduced potential milk yield is an important component of mastitis costs in dairy cows. The first aim of this study was to assess associations between somatic cell count (SCC) during the first lactation, and cumulative milk yield over the first lacta... Read More about Association between somatic cell count during the first lactation and the cumulative milk yield of cows in Irish dairy herds.

Survey of the UK veterinary profession: common species and conditions nominated by veterinarians in practice (2014)
Journal Article
Nielsen, T., Dean, R. S., Robinson, N., Massey, A., & Brennan, M. L. (in press). Survey of the UK veterinary profession: common species and conditions nominated by veterinarians in practice. Veterinary Record, 174(13), https://doi.org/10.1136/vr.101745

The practice of evidence-based veterinary medicine involves the utilisation of scientific evidence for clinical decision making. To enable this, research topics pertinent to clinical practice need to be identified, and veterinary clinicians are best... Read More about Survey of the UK veterinary profession: common species and conditions nominated by veterinarians in practice.

Computed tomography analysis of guinea pig bone: architecture, bone thickness and dimensions throughout development. (2014)
Journal Article
Witkowska, A., Alibhai, A., Hughes, C., Price, J., Klisch, K., Sturrock, C., & Rutland, C. S. (2014). Computed tomography analysis of guinea pig bone: architecture, bone thickness and dimensions throughout development. PeerJ, 2, Article e615. https://doi.org/10.7717/peerj.615

The domestic guinea pig, Cavia aperea f. porcellus, belongs to the Caviidae family of rodents. It is an important species as a pet, a source of food and in medical research. Adult weight is achieved at 8-12 months and life expectancy is ?5-6 years. O... Read More about Computed tomography analysis of guinea pig bone: architecture, bone thickness and dimensions throughout development..

Development of a surveillance scheme for equine influenza in the UK and characterisation of viruses isolated in Europe, Dubai and the USA from 2010-2012 (2014)
Journal Article
Woodward, A. L., Rash, A. S., Blinman, D., Bowman, S., Chambers, T. M., Daly, J. M., …Elton, D. M. (2014). Development of a surveillance scheme for equine influenza in the UK and characterisation of viruses isolated in Europe, Dubai and the USA from 2010-2012. Veterinary Microbiology, 169(3-4), https://doi.org/10.1016/j.vetmic.2013.11.039

Equine influenza viruses are a major cause of respiratory disease in horses worldwide and undergo antigenic drift. Several outbreaks of equine influenza occurred worldwide during 2010-2012, including in vaccinated animals, highlighting the importance... Read More about Development of a surveillance scheme for equine influenza in the UK and characterisation of viruses isolated in Europe, Dubai and the USA from 2010-2012.

The impact of cafeteria feeding during lactation in the rat on novel object discrimination in the offspring (2014)
Journal Article
Wright, T., King, M., Davey, W., Langley-Evans, S. . C., & Voigt, J. (2014). The impact of cafeteria feeding during lactation in the rat on novel object discrimination in the offspring. British Journal of Nutrition, 112, https://doi.org/10.1017/S0007114514003134

There is increasing evidence that hyperenergetic diets impact on memory in rodents. However, it is largely unknown how diets, such as a cafeteria diet (CD), that mimic a Western diet act on learning and memory, in particular when fed during early sta... Read More about The impact of cafeteria feeding during lactation in the rat on novel object discrimination in the offspring.

The utility of low-density genotyping for imputation in the Thoroughbred horse (2014)
Journal Article
Corbin, L., Kranis, A., Blott, S., Swinburne, J., Vaudin, M., Bishop, S., & Woolliams, J. (2014). The utility of low-density genotyping for imputation in the Thoroughbred horse. Genetics Selection Evolution, 46, Article 9. https://doi.org/10.1186/1297-9686-46-9

Background Despite the dramatic reduction in the cost of high-density genotyping that has occurred over the last decade, it remains one of the limiting factors for obtaining the large datasets required for genomic studies of disease in the horse. In... Read More about The utility of low-density genotyping for imputation in the Thoroughbred horse.