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Acinar cell carcinoma of exocrine pancreas in two horses

de Brot, Simone; Junge, Hannah; Hilbe, Monika

Authors

Simone de Brot

Hannah Junge

Monika Hilbe



Abstract

Two horses were presented with non-specific clinical signs of several weeks' duration and were humanely destroyed due to a poor prognosis. At necropsy examination, both horses had multiple small, white nodules replacing pancreatic tissue and involving the serosal surface of the abdominal cavity, the liver and the lung. Microscopically, neoplastic cells were organized in acini and contained abundant (case 1) or sparse (horse 2) intracytoplasmic zymogen granules. Immunohistochemically, both tumours expressed amylase and pan-cytokeratin, but not insulin or neuron-specific enolase. In case 2, a low percentage of neoplastic cells expressed glucagon and synaptophysin. The presence of zymogen granules was confirmed in both cases by electron microscopy and occasional fibrillary or glucagon granules were observed in cases 1 and 2, respectively. A diagnosis of pancreatic acinar cell carcinoma was established in both horses.

Journal Article Type Article
Publication Date May 31, 2014
Journal Journal of Comparative Pathology
Print ISSN 0021-9975
Electronic ISSN 1532-3129
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 150
Issue 4
APA6 Citation de Brot, S., Junge, H., & Hilbe, M. (2014). Acinar cell carcinoma of exocrine pancreas in two horses. Journal of Comparative Pathology, 150(4), https://doi.org/10.1016/j.jcpa.2014.01.003
DOI https://doi.org/10.1016/j.jcpa.2014.01.003
Keywords electron microscopy; fibrillary granules; immunohistochemistry; pancreas
Publisher URL http://www.sciencedirect.com/science/article/pii/S0021997514000048
Copyright Statement Copyright information regarding this work can be found at the following address: http://eprints.nottingh.../end_user_agreement.pdf

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://eprints.nottingham.ac.uk/end_user_agreement.pdf





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