All Outputs (88)

Study of NAP adsorption and assembly on the surface of HOPG (2014)
Journal Article

NAP is an octapeptide that has demonstrated a neuroprotective/therapeutic efficacy at very low concentrations in preclinical studies and in a number of clinical trials. Yet little is known about its structural organization at low concentrations. Here... Read More about Study of NAP adsorption and assembly on the surface of HOPG.

Exploiting the kinetic interplay between GPIb -VWF binding interfaces to regulate hemostasis and thrombosis (2014)
Journal Article

Platelet–von Willebrand factor (VWF) interactions must be tightly regulated in order to promote effective hemostasis and prevent occlusive thrombus formation. However, it is unclear what role the inherent properties of the bond formed between the pla... Read More about Exploiting the kinetic interplay between GPIb -VWF binding interfaces to regulate hemostasis and thrombosis.

Bacterial Attachment to Polymeric Materials Correlates with Molecular Flexibility and Hydrophilicity (2014)
Journal Article

A new class of material resistant to bacterial attachment has been discovered that is formed from polyacrylates with hydrocarbon pendant groups. In this study, the relationship between the nature of the hydrocarbon moiety and resistance to bacteria i... Read More about Bacterial Attachment to Polymeric Materials Correlates with Molecular Flexibility and Hydrophilicity.

In vivo evaluation of different formulation strategies for sustained release injectables of a poorly soluble HIV protease inhibitor (2014)
Journal Article

At present no scientific rationale exists for selecting a particular enabling strategy to formulate a poorly water-soluble drug, although this is crucial as it will influence the in vivo performance of the resulting formulation. This study provides a... Read More about In vivo evaluation of different formulation strategies for sustained release injectables of a poorly soluble HIV protease inhibitor.

A New Porphyrin for the Preparation of Functionalized Water-Soluble Gold Nanoparticles with Low Intrinsic Toxicity (2014)
Journal Article

Biased allosteric modulation at the CaS receptor engendered by structurally diverse calcimimetics (2014)
Journal Article

Background and Purpose Clinical use of cinacalcet in hyperparathyroidism is complicated by its tendency to induce hypocalcaemia, arising partly from activation of calcium-sensing receptors (CaS receptors) in the thyroid and stimulation of calcitonin... Read More about Biased allosteric modulation at the CaS receptor engendered by structurally diverse calcimimetics.

A Thermoresponsive and Magnetic Colloid for 3D Cell Expansion and Reconfiguration (2014)
Journal Article

A dual thermoresponsive and magnetic colloidal gel matrix is described for enhanced stem-cell culture. The combined properties of the material allow enzyme-free passaging and expansion of mesenchymal stem cells, as well as isolation of cells postcult... Read More about A Thermoresponsive and Magnetic Colloid for 3D Cell Expansion and Reconfiguration.

Technological development of intracellular polysilicon–chromium–gold chips for orthogonal chemical functionalization (2014)
Journal Article

Increasingly, advances in microtechnologies are focused on obtaining new chips intended for applications in fields such as nanomedicine and cell biology, taking advantage of the ability of microelectronics to manufacture devices with cell dimensions... Read More about Technological development of intracellular polysilicon–chromium–gold chips for orthogonal chemical functionalization.

An evaluation of a multi-site community pharmacy-based chronic obstructive pulmonary disease support service (2014)
Journal Article

Objectives Chronic obstructive pulmonary disease (COPD) is a progressive chronic condition that can be effectively managed by smoking-cessation, optimising prescribed therapy and providing treatment to prevent chest infections from causing hospitalis... Read More about An evaluation of a multi-site community pharmacy-based chronic obstructive pulmonary disease support service.

Preparation and structural analysis of (±)-cis-ethyl 2-sulfanylidenedecahydro-1,6-naphthyridine-6-carboxylate and (±)-trans-ethyl 2-oxooctahydro-1H-pyrrolo[3,2-c]pyridine-5-carboxylate (2014)
Journal Article

Bicycle ring closure on a mixture of (4aS,8aR)- and (4aR,8aS)-ethyl 2-oxodecahydro-1,6-naphthyridine-6-carboxylate, followed by conversion of the separated cis and trans isomers to the corresponding thioamide derivatives, gave (4aSR,8aRS)-ethyl 2-sul... Read More about Preparation and structural analysis of (±)-cis-ethyl 2-sulfanylidenedecahydro-1,6-naphthyridine-6-carboxylate and (±)-trans-ethyl 2-oxooctahydro-1H-pyrrolo[3,2-c]pyridine-5-carboxylate.

Formulations for modulation of protein release from large-size PLGA microparticles for tissue engineering (2014)
Journal Article

In this study we present an approach to pre-program lysozyme release from large size (100–300 μm) poly(dl-lactic acid-co-glycolic acid) (PLGA) microparticles. This approach involved blending in-house synthesized triblock copolymers with a PLGA 85:15.... Read More about Formulations for modulation of protein release from large-size PLGA microparticles for tissue engineering.

Chronic obstructive pulmonary disease case finding by community pharmacists: A potential cost-effective public health intervention (2014)
Journal Article

Objectives This study aims to pilot a community pharmacy chronic obstructive pulmonary disease (COPD) case finding service in England, estimating costs and effects. Methods Patients potentially at risk of COPD were screened with validated tools. Smok... Read More about Chronic obstructive pulmonary disease case finding by community pharmacists: A potential cost-effective public health intervention.

A facile approach to tryptophan derivatives for the total synthesis of argyrin analogues (2014)
Journal Article

A facile route has been established for the synthesis of indole-substituted (S)-tryptophans from corresponding indoles, which utilizes a chiral auxiliary-facilitated Strecker amino acid synthesis strategy. The chiral auxiliary reagents evaluated were... Read More about A facile approach to tryptophan derivatives for the total synthesis of argyrin analogues.

Gelation properties of self-assembling N-acyl modified cytidine derivatives (2014)
Journal Article

In this study we report the synthesis of new cytidine derived gelators possessing acyl chains of different lengths. These low molecular weight gelators were shown to form self-supporting gels at 0.5 % (w/v) in binary systems of aqueous miscible polar... Read More about Gelation properties of self-assembling N-acyl modified cytidine derivatives.

Electrically-driven modulation of surface-grafted RGD peptides for manipulation of cell adhesion (2014)
Journal Article

The mechanisms of nanoparticle internalization and transport across an intestinal epithelial cell model: effect of size and surface charge (2014)
Journal Article

This study investigated the effect of nanoparticle size (50 and 100 nm) and surface charge on their interaction with Caco-2 monolayers as a model of the intestinal epithelium, including cell internalization pathways and the level of transepithelial t... Read More about The mechanisms of nanoparticle internalization and transport across an intestinal epithelial cell model: effect of size and surface charge.

Mechanistic Insights into Allosteric Structure-Function Relationships at the M1 Muscarinic Acetylcholine Receptor (2014)
Journal Article

Benzylquinolone carboxylic acid (BQCA) is the first highly selective positive allosteric modulator (PAM) for the M1 muscarinic acetylcholine receptor (mAChR), but it possesses low affinity for the allosteric site on the receptor. More recent drug dis... Read More about Mechanistic Insights into Allosteric Structure-Function Relationships at the M1 Muscarinic Acetylcholine Receptor.

Combination of (M)DSC and Surface Analysis to Study the Phase Behaviour and Drug Distribution of Ternary Solid Dispersions (2014)
Journal Article

Purpose: Miscibility of the different compounds that make up a solid dispersion based formulation play a crucial role in the drug release profile and physical stability of the solid dispersion as it defines the phase behaviour of the dispersion. The... Read More about Combination of (M)DSC and Surface Analysis to Study the Phase Behaviour and Drug Distribution of Ternary Solid Dispersions.

Spectroscopic Studies of Internal Injector Deposits (IDID) Resulting from the Use of Non-Commercial Low Molecular Weight Polyisobutylenesuccinimide (PIBSI) (2014)
Journal Article

Copyright © 2014 SAE International. Since 2009, there has been a rise in deposits of various types found in diesel fuel injection systems. They have been identified in the filter, the injector tip and recently inside the injector. The latter internal... Read More about Spectroscopic Studies of Internal Injector Deposits (IDID) Resulting from the Use of Non-Commercial Low Molecular Weight Polyisobutylenesuccinimide (PIBSI).

Rapid Detection of Peptide Markers for Authentication Purposes in Raw and Cooked Meat Using Ambient Liquid Extraction Surface Analysis Mass Spectrometry (2014)
Journal Article

In this paper, our previously developed ambient LESA-MS methodology is implemented to analyze five types of thermally treated meat species, namely beef, pork, horse, chicken, and turkey meat, in order to select and identify heat-stable and species-sp... Read More about Rapid Detection of Peptide Markers for Authentication Purposes in Raw and Cooked Meat Using Ambient Liquid Extraction Surface Analysis Mass Spectrometry.