Gelation properties of self-assembling N-acyl modified cytidine derivatives

Skilling, Kathryn J.; Ndungu, A.; Kellam, Barrie; Ashford, M.; Bradshaw, Tracey D.; Marlow, Maria

Abstract

In this study we report the synthesis of new cytidine derived gelators possessing acyl chains of different lengths. These low molecular weight gelators were shown to form self-supporting gels at 0.5 % (w/v) in binary systems of aqueous miscible polar organic solvent and water. The representative gels were studied using rheology and their fibrillar structure confirmed by TEM imaging and FTIR. We further demonstrated the use of these gels as potential drug delivery platforms by monitoring release characteristics of both high and low molecular weight fluorescently labelled tracers.

Citation

Skilling, K. J., Ndungu, A., Kellam, B., Ashford, M., Bradshaw, T. D., & Marlow, M. (in press). Gelation properties of self-assembling N-acyl modified cytidine derivatives. Journal of Materials Chemistry B, 2(47), https://doi.org/10.1039/C4TB01375A

• Journal Article Type: Article
• Acceptance Date: Oct 18, 2014
• Online Publication Date: Oct 22, 2014
• Deposit Date: Oct 4, 2016
• Publicly Available Date: Oct 4, 2016
• Journal: Journal of Materials Chemistry B
• Print ISSN: 2050-750X
• Electronic ISSN: 2050-7518
• Publisher: Royal Society of Chemistry
• Peer Reviewed: Peer Reviewed
• Volume: 2
• Issue: 47
• DOI: https://doi.org/10.1039/C4TB01375A
• Public URL: https://nottingham-repository.worktribe.com/output/737814
• Publisher URL: http://pubs.rsc.org/en/Content/ArticleLanding/2014/TB/C4TB01375A#!divAbstract
• Contract Date: Oct 4, 2016