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Gelation properties of self-assembling N-acyl modified cytidine derivatives

Skilling, Kathryn J.; Ndungu, A.; Kellam, Barrie; Ashford, M.; Bradshaw, Tracey D.; Marlow, Maria

Authors

Kathryn J. Skilling

A. Ndungu

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BARRIE KELLAM BARRIE.KELLAM@NOTTINGHAM.AC.UK
Professor of Medicinal Chemistry

M. Ashford

Tracey D. Bradshaw



Abstract

In this study we report the synthesis of new cytidine derived gelators possessing acyl chains of different lengths. These low molecular weight gelators were shown to form self-supporting gels at 0.5 % (w/v) in binary systems of aqueous miscible polar organic solvent and water. The representative gels were studied using rheology and their fibrillar structure confirmed by TEM imaging and FTIR. We further demonstrated the use of these gels as potential drug delivery platforms by monitoring release characteristics of both high and low molecular weight fluorescently labelled tracers.

Citation

Skilling, K. J., Ndungu, A., Kellam, B., Ashford, M., Bradshaw, T. D., & Marlow, M. (in press). Gelation properties of self-assembling N-acyl modified cytidine derivatives. Journal of Materials Chemistry B, 2(47), https://doi.org/10.1039/C4TB01375A

Journal Article Type Article
Acceptance Date Oct 18, 2014
Online Publication Date Oct 22, 2014
Deposit Date Oct 4, 2016
Publicly Available Date Oct 4, 2016
Journal Journal of Materials Chemistry B
Print ISSN 2050-750X
Electronic ISSN 2050-750X
Publisher Royal Society of Chemistry
Peer Reviewed Peer Reviewed
Volume 2
Issue 47
DOI https://doi.org/10.1039/C4TB01375A
Public URL http://eprints.nottingham.ac.uk/id/eprint/37331
Publisher URL http://pubs.rsc.org/en/Content/ArticleLanding/2014/TB/C4TB01375A#!divAbstract
Copyright Statement Copyright information regarding this work can be found at the following address: http://eprints.nottingh.../end_user_agreement.pdf

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final paper Mat chem B 2014.pdf (592 Kb)
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Copyright Statement
Copyright information regarding this work can be found at the following address: http://eprints.nottingham.ac.uk/end_user_agreement.pdf





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