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Evaluation of cannabidiol nanoparticles and nanoemulsion biodistribution in the central nervous system after intrathecal administration for the treatment of pain

Muresan, Paula; Woodhams, Stephen; Smith, Fiona; Taresco, Vincenzo; Shah, Jaymin; Wong, Mei; Chapman, Victoria; Smith, Stuart; Hathway, Gareth; Rahman, Ruman; Gershkovich, Pavel; Marlow, Maria

Evaluation of cannabidiol nanoparticles and nanoemulsion biodistribution in the central nervous system after intrathecal administration for the treatment of pain Thumbnail


Authors

Paula Muresan

Fiona Smith

Jaymin Shah

Mei Wong



Abstract

We investigated how the biodistribution of cannabidiol (CBD) within the central nervous system (CNS) is influenced by two different formulations, an oil-in-water (O/W) nanoemulsion and polymer-coated nanoparticles (PCNPs). We observed that both CBD formulations administered were preferentially retained in the spinal cord, with high concentrations reaching the brain within 10 min of administration. The CBD nanoemulsion reached Cmax in the brain at 210 ng/g within 120 min (Tmax), whereas the CBD PCNPs had a Cmax of 94 ng/g at 30 min (Tmax), indicating that rapid brain delivery can be achieved through the use of PCNPs. Moreover, the AUC0–4 h of CBD in the brain was increased 3.7-fold through the delivery of the nanoemulsion as opposed to the PCNPs, indicating higher retention of CBD at this site. Both formulations exhibited immediate anti-nociceptive effects in comparison to the respective blank formulations.

Citation

Muresan, P., Woodhams, S., Smith, F., Taresco, V., Shah, J., Wong, M., Chapman, V., Smith, S., Hathway, G., Rahman, R., Gershkovich, P., & Marlow, M. (2023). Evaluation of cannabidiol nanoparticles and nanoemulsion biodistribution in the central nervous system after intrathecal administration for the treatment of pain. Nanomedicine: Nanotechnology, Biology and Medicine, 49, Article 102664. https://doi.org/10.1016/j.nano.2023.102664

Journal Article Type Article
Acceptance Date Feb 3, 2023
Online Publication Date Mar 7, 2023
Publication Date 2023-04
Deposit Date Mar 8, 2023
Publicly Available Date Mar 10, 2023
Journal Nanomedicine: Nanotechnology, Biology and Medicine
Print ISSN 1549-9634
Electronic ISSN 1549-9642
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 49
Article Number 102664
DOI https://doi.org/10.1016/j.nano.2023.102664
Keywords Drug-delivery, Polymer-coated nanoparticles, Intrathecal, Nanoemulsion, Cannabidiol
Public URL https://nottingham-repository.worktribe.com/output/18229717
Publisher URL https://www.sciencedirect.com/science/article/pii/S1549963423000151?via%3Dihub