All Outputs (118)

Circadian variation in renal blood flow and kidney function in healthy volunteers monitored using non-invasive magnetic resonance imaging (2020)
Journal Article
Eckerbom, P., Hansell, P., Cox, E., Buchanan, C., Weis, J., Palm, F., …Liss, P. (2020). Circadian variation in renal blood flow and kidney function in healthy volunteers monitored using non-invasive magnetic resonance imaging. AJP - Renal Physiology, 319(6), F966-F978. https://doi.org/10.1152/ajprenal.00311.2020

Circadian regulation of kidney function is involved in maintaining whole-body homeostasis and dysfunctional circadian rhythm can potentially be involved in disease development. Magnetic Resonance Imaging (MRI)provides reliable and reproducible repeti... Read More about Circadian variation in renal blood flow and kidney function in healthy volunteers monitored using non-invasive magnetic resonance imaging.

Effective connectivity of the right anterior insula in schizophrenia: the salience network and task-negative to task-positive transition (2020)
Journal Article
Luo, Q., Pan, B., Gu, H., Simmonite, M., Francis, S., Liddle, P. F., & Palaniyappan, L. (2020). Effective connectivity of the right anterior insula in schizophrenia: the salience network and task-negative to task-positive transition. NeuroImage: Clinical, 28, Article 102377. https://doi.org/10.1016/j.nicl.2020.102377

Triple network dysfunction theory of schizophrenia postulates that the interaction between the default-mode and the fronto-parietal executive network is disrupted by aberrant salience signals from the right anterior insula (rAI). To date, it is not c... Read More about Effective connectivity of the right anterior insula in schizophrenia: the salience network and task-negative to task-positive transition.

A nociresponsive specific area of human somatosensory cortex within BA3a: BA3c? (2020)
Journal Article
Sanchez Panchuelo, R. M., Eldeghaidy, S., Marshall, A., McGlone, F., Francis, S. T., & Favorov, O. (2020). A nociresponsive specific area of human somatosensory cortex within BA3a: BA3c?. NeuroImage, 221, Article 117187. https://doi.org/10.1016/j.neuroimage.2020.117187

© 2020 It is well recognized that in primates, including humans, noxious body stimulation evokes a neural response in the posterior bank of the central sulcus, in Brodmann cytoarchitectonic subdivisions 3b and 1 of the primary somatosensory cortex. T... Read More about A nociresponsive specific area of human somatosensory cortex within BA3a: BA3c?.

A probabilistic atlas of finger dominance in the primary somatosensory cortex (2020)
Journal Article
O’Neill, G., Sengupta, A., Asghar, M., Barratt, E., Besle, J., Schluppeck, D., …Sanchez Panchuelo, R. (2020). A probabilistic atlas of finger dominance in the primary somatosensory cortex. NeuroImage, 217, Article 116880. https://doi.org/10.1016/j.neuroimage.2020.116880

With the advent of ultra-high field (7T), high spatial resolution functional MRI (fMRI) has allowed the differentiation of the cortical representations of each of the digits at an individual-subject level in human primary somatosensory cortex (S1). H... Read More about A probabilistic atlas of finger dominance in the primary somatosensory cortex.

Consensus-based technical recommendations for clinical translation of renal ASL MRI (2019)
Journal Article
Nery, F., Buchanan, C. E., Harteveld, A. A., Odudu, A., Bane, O., Cox, E. F., …Fernández-Seara, M. A. (2020). Consensus-based technical recommendations for clinical translation of renal ASL MRI. Magnetic Resonance Materials in Physics, Biology and Medicine, 33(1), 141-161. https://doi.org/10.1007/s10334-019-00800-z

Objectives: To develop technical recommendations for the acquisition, processing and analysis of renal ASL data in the human kidney at 1.5T and 3T field strengths that can promote standardization of renal perfusion measurements and facilitate the com... Read More about Consensus-based technical recommendations for clinical translation of renal ASL MRI.

FU-Net: Multi-class Image Segmentation Using Feedback Weighted U-Net (2019)
Book Chapter
Jafari, M., Li, R., Xing, Y., Auer, D., Francis, S., Garibaldi, J., & Chen, X. (2019). FU-Net: Multi-class Image Segmentation Using Feedback Weighted U-Net. In Image and Graphics: 10th International Conference, ICIG 2019, Beijing, China, August 23–25, 2019, Proceedings, Part II (529-537). Springer Verlag. https://doi.org/10.1007/978-3-030-34110-7_44

© 2019, Springer Nature Switzerland AG. In this paper, we present a generic deep convolutional neural network (DCNN) for multi-class image segmentation. It is based on a well-established supervised end-to-end DCNN model, known as U-net. U-net is firs... Read More about FU-Net: Multi-class Image Segmentation Using Feedback Weighted U-Net.

Consensus-based technical recommendations for clinical translation of renal BOLD MRI (2019)
Journal Article
Bane, O., Mendichovszky, I. A., Dekkers, I. A., Milani, B., Deux, J., Eckerbom, P., …Prasad, P. V. (2019). Consensus-based technical recommendations for clinical translation of renal BOLD MRI. Magma, 1-17

Objectives: Harmonization of acquisition and analysis protocols is an important step in the validation of BOLD MRI as a renal biomarker. This harmonization initiative provides technical recommendations based on a consensus report with the aim to move... Read More about Consensus-based technical recommendations for clinical translation of renal BOLD MRI.

Consensus-based technical recommendations for clinical translation of renal T1 and T2 mapping MRI (2019)
Journal Article
Semple, S. I. K., Dekkers, I. A., de Boer, A., Sharma, K., Cox, E. F., Lamb, H. J., …Francis, S. (2020). Consensus-based technical recommendations for clinical translation of renal T1 and T2 mapping MRI. Magnetic Resonance Materials in Physics, Biology and Medicine, 33(1), 163-176. https://doi.org/10.1007/s10334-019-00797-5

© 2019, The Author(s). To develop technical recommendations on the acquisition and post-processing of renal longitudinal (T1) and transverse (T2) relaxation time mapping. A multidisciplinary panel consisting of 18 experts in the field of renal T1 and... Read More about Consensus-based technical recommendations for clinical translation of renal T1 and T2 mapping MRI.

Consensus-based technical recommendations for clinical translation of renal diffusion-weighted MRI (2019)
Journal Article
Ljimani, A., Caroli, A., Laustsen, C., Francis, S., Mendichovszky, I. A., Bane, O., …Sigmund, E. E. (2020). Consensus-based technical recommendations for clinical translation of renal diffusion-weighted MRI. Magnetic Resonance Materials in Physics, Biology and Medicine, 33, 177-195. https://doi.org/10.1007/s10334-019-00790-y

© 2019, European Society for Magnetic Resonance in Medicine and Biology (ESMRMB). Objectives: Standardization is an important milestone in the validation of DWI-based parameters as imaging biomarkers for renal disease. Here, we propose technical reco... Read More about Consensus-based technical recommendations for clinical translation of renal diffusion-weighted MRI.

Post-stimulus beta responses are modulated by task duration (2019)
Journal Article
Pakenham, D. O., Quinn, A. J., Fry, A., Francis, S. T., Woolrich, M. W., Brookes, M. J., & Mullinger, K. J. (2020). Post-stimulus beta responses are modulated by task duration. NeuroImage, 206, Article 116288. https://doi.org/10.1016/j.neuroimage.2019.116288

Modulation of beta-band neural oscillations during and following movement is a robust marker of brain function. In particular, the post-movement beta rebound (PMBR), which occurs on movement cessation, has been related to inhibition and connectivity... Read More about Post-stimulus beta responses are modulated by task duration.

A randomized, controlled, double-blind crossover study on the effects of isoeffective and isovolumetric intravenous crystalloid and gelatin on blood volume, and renal and cardiac hemodynamics (2019)
Journal Article
Bradley, C. R., Bragg, D. D., Cox, E. F., El-Sharkawy, A. M., Buchanan, C. E., Chowdhury, A. H., …Lobo, D. N. (2020). A randomized, controlled, double-blind crossover study on the effects of isoeffective and isovolumetric intravenous crystalloid and gelatin on blood volume, and renal and cardiac hemodynamics. Clinical Nutrition, 39(7), 2070-2079. https://doi.org/10.1016/j.clnu.2019.09.011

Background & aims
Blood volume expanding properties of colloids are superior to crystalloids. In addition to oncotic/osmotic properties, the electrolyte composition of infusions may have important effects on visceral perfusion, with infusions contai... Read More about A randomized, controlled, double-blind crossover study on the effects of isoeffective and isovolumetric intravenous crystalloid and gelatin on blood volume, and renal and cardiac hemodynamics.

The association between subcortical and cortical fMRI and lifetime noise exposure in listeners with normal hearing thresholds (2019)
Journal Article
Dewey, R. S., Francis, S. T., Guest, H., Prendergast, G., Millman, R. E., Plack, C. J., & Hall, D. A. (2020). The association between subcortical and cortical fMRI and lifetime noise exposure in listeners with normal hearing thresholds. NeuroImage, 204, Article 116239. https://doi.org/10.1016/j.neuroimage.2019.116239

© 2019 In animal models, exposure to high noise levels can cause permanent damage to hair-cell synapses (cochlear synaptopathy) for high-threshold auditory nerve fibers without affecting sensitivity to quiet sounds. This has been confirmed in several... Read More about The association between subcortical and cortical fMRI and lifetime noise exposure in listeners with normal hearing thresholds.

Two spatially distinct posterior alpha sources fulfill different functional roles in attention (2019)
Journal Article
Sokoliuk, R., Mayhew, S., Aquino, K., Wilson, R., Brookes, M., Francis, S., …Mullinger, K. (2019). Two spatially distinct posterior alpha sources fulfill different functional roles in attention. Journal of Neuroscience, 39(36), 7183-7194. https://doi.org/10.1523/jneurosci.1993-18.2019

Directing attention helps extracting relevant information and suppressing distracters. Alpha brain oscillations (8-12Hz) are crucial for this process, with power decreases facilitating processing of important information and power increases inhibitin... Read More about Two spatially distinct posterior alpha sources fulfill different functional roles in attention.

Quantitative assessment of renal structural and functional changes in chronic kidney disease using multi-parametric magnetic resonance imaging (2019)
Journal Article
Buchanan, C. E., Mahmoud, H., Cox, E. F., McCulloch, T., Prestwich, B. L., Taal, M. W., …Francis, S. T. (2020). Quantitative assessment of renal structural and functional changes in chronic kidney disease using multi-parametric magnetic resonance imaging. Nephrology Dialysis Transplantation, 35(6), 955-964. https://doi.org/10.1093/ndt/gfz129

BACKGROUND:
Multi-parametric magnetic resonance imaging (MRI) provides the potential for a more comprehensive non-invasive assessment of organ structure and function than individual MRI measures, but has not previously been comprehensively evaluated... Read More about Quantitative assessment of renal structural and functional changes in chronic kidney disease using multi-parametric magnetic resonance imaging.

The relationship between negative BOLD responses and ERS and ERD of alpha/beta oscillations in visual and motor cortex (2019)
Journal Article
Wilson, R., Mullinger, K. J., Francis, S. T., & Mayhew, S. D. (2019). The relationship between negative BOLD responses and ERS and ERD of alpha/beta oscillations in visual and motor cortex. NeuroImage, 199, 635-650. https://doi.org/10.1016/j.neuroimage.2019.06.009

Previous work has investigated the electrophysiological origins of the intra-modal (within the stimulated sensory cortex) negative BOLD fMRI response (NBR, decrease from baseline) but little attention has been paid to the origin of cross-modal NBRs,... Read More about The relationship between negative BOLD responses and ERS and ERD of alpha/beta oscillations in visual and motor cortex.

Coupling between cerebral blood flow and cerebral blood volume: contributions of different vascular compartments (2019)
Journal Article
Wesolowski, R., Blockley, N., Driver, I., Francis, S., & Gowland, P. (2019). Coupling between cerebral blood flow and cerebral blood volume: contributions of different vascular compartments. NMR in Biomedicine, 32(3), 1-11. https://doi.org/10.1002/nbm.4061

A better understanding of the coupling between changes in cerebral blood flow (CBF) and cerebral blood volume (CBV) is vital for furthering our understanding of the BOLD response. The aim of this study was to measure CBF-CBV coupling in different vas... Read More about Coupling between cerebral blood flow and cerebral blood volume: contributions of different vascular compartments.

Imaging human cortical responses to intraneural microstimulation using magnetoencephalography (2019)
Journal Article
O'Neill, G. C., Watkins, R. H., Ackerley, R., Barratt, E. L., Sengupta, A., Asghar, M., …Francis, S. T. (2019). Imaging human cortical responses to intraneural microstimulation using magnetoencephalography. NeuroImage, 189, 329-340. https://doi.org/10.1016/j.neuroimage.2019.01.017

The sensation of touch in the glabrous skin of the human hand is conveyed by thousands of fast-conducting mechanoreceptive afferents, which can be categorised into four distinct types. The spiking properties of these afferents in the periphery in re... Read More about Imaging human cortical responses to intraneural microstimulation using magnetoencephalography.

Short-term changes observed in multi-parametric liver MRI following therapy with direct acting antivirals in chronic hepatitis C virus patients (2018)
Journal Article
Bradley, C., Scott, R., Cox, E., Palaniyappan, N., Thompson, B., Ryder, D., …Francis, S. (2019). Short-term changes observed in multi-parametric liver MRI following therapy with direct acting antivirals in chronic hepatitis C virus patients. European Radiology, 29(6), 3100–3107. https://doi.org/10.1007/s00330-018-5788-1

Methods: We applied multiparametric MRI to assess changes in liver composition, perfusion and blood flow in 17 patients before DAA therapy and after treatment completion (within 12 weeks of last DAA tablet swallowed).
Results: We observed changes in... Read More about Short-term changes observed in multi-parametric liver MRI following therapy with direct acting antivirals in chronic hepatitis C virus patients.

Addressing challenges of high spatial resolution UHF fMRI for group analysis of higher‐order cognitive tasks: An inter‐sensory task directing attention between visual and somatosensory domains (2018)
Journal Article
Aquino, K. M., Sokoliuk, R., Pakenham, D., Sanchez-Panchuelo, R. M., Hanslmayr, S., Mayhew, S. D., …Francis, S. T. (2019). Addressing challenges of high spatial resolution UHF fMRI for group analysis of higher‐order cognitive tasks: An inter‐sensory task directing attention between visual and somatosensory domains. Human Brain Mapping, 40(4), 1298-1316. https://doi.org/10.1002/hbm.24450

Functional MRI at ultra-high field (UHF, ≥7T) provides significant increases in BOLD contrast-to-noise ratio (CNR) compared with conventional field strength (3T), and has been exploited for reduced field-of-view, high spatial resolution mapping of pr... Read More about Addressing challenges of high spatial resolution UHF fMRI for group analysis of higher‐order cognitive tasks: An inter‐sensory task directing attention between visual and somatosensory domains.

Is human auditory cortex organization compatible with the monkey model? Contrary evidence from ultra-high-field functional and structural MRI (2018)
Journal Article
Besle, J., Mougin, O., Sánchez-Panchuelo, R.-M., Lanting, C., Gowland, P., Bowtell, R., …Krumbholz, K. (2018). Is human auditory cortex organization compatible with the monkey model? Contrary evidence from ultra-high-field functional and structural MRI. Cerebral Cortex, 29(1), 410-428. https://doi.org/10.1093/cercor/bhy267

It is commonly assumed that the human auditory cortex is organized similarly to that of macaque monkeys, where the primary region, or “core,” is elongated parallel to the tonotopic axis (main direction of tonotopic gradients), and subdivided across t... Read More about Is human auditory cortex organization compatible with the monkey model? Contrary evidence from ultra-high-field functional and structural MRI.