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Coupling between cerebral blood flow and cerebral blood volume: contributions of different vascular compartments

Wesolowski, Roman; Blockley, Nic; Driver, Ian; Francis, Susan; Gowland, Penny


Roman Wesolowski

Ian Driver


A better understanding of the coupling between changes in cerebral blood flow (CBF) and cerebral blood volume (CBV) is vital for furthering our understanding of the BOLD response. The aim of this study was to measure CBF-CBV coupling in different vascular compartments during neural activation. Three haemodynamic parameters were measured during a visual stimulus. Look-Locker Flow-sensitive Alternating Inversion Recovery (LL-FAIR) was used to measure changes in CBF and arterial CBV (CBVa) using sequence parameters optimised for each contrast. Changes in total CBV (CBVtot) were measured using a Gadolinium based contrast agent technique. Haemodynamic changes were extracted from a region of interest based on voxels that were activated in the CBF experiments. The CBF-CBVtot coupling constant αtot was measured as 0.16±0.14 and the CBF-CBVa coupling constant αa was measured as 0.65±0.24. Using a two-compartment model of the vasculature (arterial and venous), the change in venous CBV (CBVv) was predicted for an assumed value of baseline arterial and venous blood volume. These results will enhance the accuracy and reliability of applications that rely on models of the BOLD response, such as calibrated BOLD.


Wesolowski, R., Blockley, N., Driver, I., Francis, S., & Gowland, P. (2019). Coupling between cerebral blood flow and cerebral blood volume: contributions of different vascular compartments. NMR in Biomedicine, 32(3), 1-11.

Journal Article Type Article
Acceptance Date Oct 19, 2018
Online Publication Date Jan 18, 2019
Publication Date Mar 1, 2019
Deposit Date Jan 8, 2019
Publicly Available Date Jan 22, 2019
Journal NMR in Biomedicine
Print ISSN 0952-3480
Electronic ISSN 1099-1492
Publisher Wiley
Peer Reviewed Peer Reviewed
Volume 32
Issue 3
Article Number e4061
Pages 1-11
Keywords arterial spin labelling, BOLD, CBF?CBV coupling, cerebral blood volume, fMR
Public URL
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