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Is human auditory cortex organization compatible with the monkey model? Contrary evidence from ultra-high-field functional and structural MRI

Besle, Julien; Mougin, Olivier; Sánchez-Panchuelo, Rosa-María; Lanting, Cornelis; Gowland, Penny; Bowtell, Richard; Francis, Susan; Krumbholz, Katrin

Authors

Julien Besle

Cornelis Lanting



Abstract

It is commonly assumed that the human auditory cortex is organized similarly to that of macaque monkeys, where the primary region, or “core,” is elongated parallel to the tonotopic axis (main direction of tonotopic gradients), and subdivided across this axis into up to 3 distinct areas (A1, R, and RT), with separate, mirror-symmetric tonotopic gradients. This assumption, however, has not been tested until now. Here, we used high-resolution ultra-high-field (7 T) magnetic resonance imaging (MRI) to delineate the human core and map tonotopy in 24 individual hemispheres. In each hemisphere, we assessed tonotopic gradients using principled, quantitative analysis methods, and delineated the core using 2 independent (functional and structural) MRI criteria. Our results indicate that, contrary to macaques, the human core is elongated perpendicular rather than parallel to the main tonotopic axis, and that this axis contains no more than 2 mirror-reversed gradients within the core region. Previously suggested homologies between these gradients and areas A1 and R in macaques were not supported. Our findings suggest fundamental differences in auditory cortex organization between humans and macaques.

Journal Article Type Article
Publication Date Oct 24, 2018
Journal Cerebral Cortex
Print ISSN 1047-3211
Electronic ISSN 1460-2199
Publisher Oxford University Press (OUP)
Peer Reviewed Peer Reviewed
APA6 Citation Besle, J., Mougin, O., Sánchez-Panchuelo, R., Lanting, C., Gowland, P., Bowtell, R., …Krumbholz, K. (2018). Is human auditory cortex organization compatible with the monkey model? Contrary evidence from ultra-high-field functional and structural MRI. Cerebral Cortex, doi:10.1093/cercor/bhy267
DOI https://doi.org/10.1093/cercor/bhy267
Keywords Cognitive Neuroscience; Cellular and Molecular Neuroscience
Publisher URL https://academic.oup.com/cercor/advance-article/doi/10.1093/cercor/bhy267/5144239

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