Skip to main content

Research Repository

Advanced Search

Addressing challenges of high spatial resolution UHF fMRI for group analysis of higher‐order cognitive tasks: An inter‐sensory task directing attention between visual and somatosensory domains

Aquino, Kevin M.; Sokoliuk, Rodika; Pakenham, Daisie; Sanchez-Panchuelo, Rosa Maria; Hanslmayr, Simon; Mayhew, Stephen D.; Mullinger, Karen J.; Francis, Susan T.

Authors

Kevin M. Aquino

Rodika Sokoliuk

Daisie Pakenham

Simon Hanslmayr

Stephen D. Mayhew



Abstract

Functional MRI at ultra-high field (UHF, ≥7T) provides significant increases in BOLD contrast-to-noise ratio (CNR) compared with conventional field strength (3T), and has been exploited for reduced field-of-view, high spatial resolution mapping of primary sensory areas. Applying these high spatial resolution methods to investigate whole brain functional responses to higher-order cognitive tasks leads to a number of challenges, in particular how to perform robust group-level statistical analyses.
This study addresses these challenges using an inter-sensory cognitive task which modulates top-down attention at graded levels between the visual and somatosensory domains. At the individual level, highly focal functional activation to the task and task difficulty (modulated by attention levels) were detectable due to the high CNR at UHF. However, to assess group level effects, both anatomical and functional variability must be considered during analysis. We demonstrate the importance of surface over volume normalization and the requirement of no spatial smoothing when assessing highly focal activity. Using novel group analysis on anatomically parcellated brain regions, we show that in higher cognitive areas (parietal and dorsal-lateral-prefrontal cortex) fMRI responses to graded attention levels were modulated quadratically, whilst in visual cortex and VIP, responses were modulated linearly. These group fMRI responses were not seen clearly using conventional second-level GLM analyses, illustrating the limitations of a conventional approach when investigating such focal responses in higher cognitive regions which are more anatomically variable. The approaches demonstrated here complement other advanced analysis methods such as multi-variate pattern analysis, allowing UHF to be fully exploited in cognitive neuroscience.

Journal Article Type Article
Publication Date 2019-03
Journal Human Brain Mapping
Print ISSN 1065-9471
Electronic ISSN 1097-0193
Publisher Wiley
Peer Reviewed Peer Reviewed
Volume 40
Issue 4
Pages 1298-1316
APA6 Citation Aquino, K. M., Sokoliuk, R., Pakenham, D., Sanchez-Panchuelo, R. M., Hanslmayr, S., Mayhew, S. D., …Francis, S. T. (2019). Addressing challenges of high spatial resolution UHF fMRI for group analysis of higher‐order cognitive tasks: An inter‐sensory task directing attention between visual and somatosensory domains. Human Brain Mapping, 40(4), 1298-1316. https://doi.org/10.1002/hbm.24450
DOI https://doi.org/10.1002/hbm.24450
Keywords Anatomy; Radiological and Ultrasound Technology; Radiology Nuclear Medicine and imaging; Neurology; Clinical Neurology
Publisher URL https://onlinelibrary.wiley.com/doi/full/10.1002/hbm.24450

Files





You might also like



Downloadable Citations

;