Outputs (189)

Deconditioning in quiescent Crohn’s Disease patients with heightened fatigue perception (2025)
Journal Article
McGing, J. J., Serres, S., Nicholas, R., Gupta, A., Radford, S. J., Nixon, A. V., Mallinson, J., Bradley, C., Bawden, S., Francis, S. T., Greenhaff, P. L., & Moran, G. W. (2025). Deconditioning in quiescent Crohn’s Disease patients with heightened fatigue perception. Journal of Crohn's and Colitis, 19(1), Article jjae194. https://doi.org/10.1093/ecco-jcc/

Background & Objective

IBD fatigue aetiology is poorly understood. This study quantified body composition and physical function alongside proton magnetic resonance imaging (1H MRI) and spectroscopy (31P MRS) measures of organ structure and functio... Read More about Deconditioning in quiescent Crohn’s Disease patients with heightened fatigue perception.

A standardized MRI phantom for dissolved phase 129Xe MRI (2024)
Journal Article
Filkins, M., Harrison, A., Collier, G. J., Norquay, G., Wild, J. M., Rigby, S. P., Pavlovskaya, G. E., & Meersmann, T. (2024). A standardized MRI phantom for dissolved phase 129Xe MRI. Journal of Magnetic Resonance, 21, Article 100175. https://doi.org/10.1016/j.jmro.2024.100175

Pulmonary MRI of hyperpolarized xenon-129 (hp129Xe) dissolved in the lung parenchyma and vascular phase is gaining increasing attention for clinical assessment of gas exchange in multiple diseases. These conditions can involve thickening of barrier t... Read More about A standardized MRI phantom for dissolved phase 129Xe MRI.

Combined magnetic resonance imaging, high resolution manometry and a randomised trial of bisacodyl versus hyoscine shows the significance of an enlarged colon in constipation: the RECLAIM study (2024)
Journal Article
Wilkinson-Smith, V., Scott, M., Menys, A., Wiklendt, L., MARCIANI, L., Atkinson, D., Sansone, S., Zdanavciene, A., Coupland, C., Knowles, C., Dinning, P., Taylor, S., Gowland, P., Hoad, C., Corsetti, M., & Spiller, R. (2025). Combined magnetic resonance imaging, high resolution manometry and a randomised trial of bisacodyl versus hyoscine shows the significance of an enlarged colon in constipation: the RECLAIM study. Gut, 74(1), 35-44. https://doi.org/10.1136/gutjnl-2024-332755

Background
Colonic motility in constipation can be assessed non-invasively using MRI.

Objective
To compare MRI with high resolution colonic manometry (HRCM) for predicting treatment response.

Design
Part 1: 44 healthy volunteers (HV), 43... Read More about Combined magnetic resonance imaging, high resolution manometry and a randomised trial of bisacodyl versus hyoscine shows the significance of an enlarged colon in constipation: the RECLAIM study.

Determinants of cerebral blood flow and arterial transit time in healthy older adults (2024)
Journal Article
Feron, J., Segaert, K., Rahman, F., Fosstveit, S. H., Joyce, K. E., Gilani, A., Lohne-Seiler, H., Berntsen, S., Mullinger, K. J., & Lucas, S. J. (2024). Determinants of cerebral blood flow and arterial transit time in healthy older adults. Aging, 16(18), 12473-12497. https://doi.org/10.18632/aging.206112

Cerebral blood flow (CBF) and arterial transit time (ATT), markers of brain vascular health, worsen with age. The primary aim of this cross-sectional study was to identify modifiable determinants of CBF and ATT in healthy older adults (n = 78, aged 6... Read More about Determinants of cerebral blood flow and arterial transit time in healthy older adults.

Greater hepatic lipid saturation is associated with impaired glycaemic regulation in men with metabolic dysfunction‐associated steatotic liver disease but is not altered by 6 weeks of exercise training (2024)
Journal Article
Willis, S. A., Malaikah, S., Bawden, S. J., Sherry, A. P., Sargeant, J. A., Coull, N. A., Bradley, C. R., Rowlands, A., Naim, I., Ennequin, G., Yates, T., Waheed, G., Gowland, P., Stensel, D. J., Webb, D. R., Davies, M. J., Aithal, G. P., & King, J. A. (2024). Greater hepatic lipid saturation is associated with impaired glycaemic regulation in men with metabolic dysfunction‐associated steatotic liver disease but is not altered by 6 weeks of exercise training. Diabetes, Obesity and Metabolism, 26(9), 4030-4042. https://doi.org/10.1111/dom.15755

Aims: To examine the impact of impaired glycaemic regulation (IGR) and exercise training on hepatic lipid composition in men with metabolic dysfunction‐associated steatotic liver disease (MASLD). Materials and Methods: In Part A (cross‐sectional desi... Read More about Greater hepatic lipid saturation is associated with impaired glycaemic regulation in men with metabolic dysfunction‐associated steatotic liver disease but is not altered by 6 weeks of exercise training.

DYNamic Assessment of Multi‐Organ level dysfunction in patients recovering from COVID‐19: DYNAMO COVID‐19 (2024)
Journal Article
Gupta, A., Nicholas, R., McGing, J. J., Nixon, A. V., Mallinson, J. E., McKeever, T. M., Bradley, C. R., Piasecki, M., Cox, E. F., Bonnington, J., Lord, J. M., Brightling, C. E., Evans, R. A., Hall, I. P., Francis, S. T., Greenhaff, P. L., & Bolton, C. E. (2024). DYNamic Assessment of Multi‐Organ level dysfunction in patients recovering from COVID‐19: DYNAMO COVID‐19. Experimental Physiology, 109(8), 1274-1291. https://doi.org/10.1113/ep091590

We evaluated the impacts of COVID-19 on multi-organ and metabolic function in patients following severe hospitalised infection compared to controls. Patients (n = 21) without previous diabetes, cardiovascular or cerebrovascular disease were recruited... Read More about DYNamic Assessment of Multi‐Organ level dysfunction in patients recovering from COVID‐19: DYNAMO COVID‐19.

Post‐task responses following working memory and movement are driven by transient spectral bursts with similar characteristics (2024)
Journal Article
Coleman, S. C., Seedat, Z. A., Pakenham, D. O., Quinn, A. J., Brookes, M. J., Woolrich, M. W., & Mullinger, K. J. (2024). Post‐task responses following working memory and movement are driven by transient spectral bursts with similar characteristics. Human Brain Mapping, 45(7), Article e26700. https://doi.org/10.1002/hbm.26700

The post-movement beta rebound has been studied extensively using magnetoencephalography (MEG) and is reliably modulated by various task parameters as well as illness. Our recent study showed that rebounds, which we generalise as “post-task responses... Read More about Post‐task responses following working memory and movement are driven by transient spectral bursts with similar characteristics.

Fast and High‐Resolution T2 Mapping Based on Echo Merging Plus k‐t Undersampling with Reduced Refocusing Flip Angles (TEMPURA) as Methods for Human Renal MRI (2024)
Journal Article
Li, H., Priest, A. N., Horvat‐Menih, I., Huang, Y., Li, S., Stewart, G. D., Mendichovszky, I. A., Francis, S. T., & Gallagher, F. A. (2024). Fast and High‐Resolution T2 Mapping Based on Echo Merging Plus k‐t Undersampling with Reduced Refocusing Flip Angles (TEMPURA) as Methods for Human Renal MRI. Magnetic Resonance in Medicine, 92(3), 1138-1148. https://doi.org/10.1002/mrm.30115

Purpose: To develop a highly accelerated multi‐echo spin‐echo method, TEMPURA, for reducing the acquisition time and/or increasing spatial resolution for kidney T2 mapping. Methods: TEMPURA merges several adjacent echoes into one k‐space by either co... Read More about Fast and High‐Resolution T2 Mapping Based on Echo Merging Plus k‐t Undersampling with Reduced Refocusing Flip Angles (TEMPURA) as Methods for Human Renal MRI.

Recommendations for quantitative cerebral perfusion MRI using multi‐timepoint arterial spin labeling: Acquisition, quantification, and clinical applications (2024)
Journal Article
Woods, J. G., Achten, E., Asllani, I., Bolar, D. S., Dai, W., Detre, J. A., Fan, A. P., Fernández‐Seara, M. A., Golay, X., Günther, M., Guo, J., Hernandez‐Garcia, L., Ho, M., Juttukonda, M. R., Lu, H., MacIntosh, B. J., Madhuranthakam, A. J., Mutsaerts, H., Okell, T. W., Parkes, L. M., …the ISMRM Perfusion Study Group. (2024). Recommendations for quantitative cerebral perfusion MRI using multi‐timepoint arterial spin labeling: Acquisition, quantification, and clinical applications. Magnetic Resonance in Medicine, 92(2), 469-495. https://doi.org/10.1002/mrm.30091

Accurate assessment of cerebral perfusion is vital for understanding the hemodynamic processes involved in various neurological disorders and guiding clinical decision-making. This guidelines article provides a comprehensive overview of quantitative... Read More about Recommendations for quantitative cerebral perfusion MRI using multi‐timepoint arterial spin labeling: Acquisition, quantification, and clinical applications.

Effects of the Fasting‐Postprandial State on Arterial Spin Labeling MRI‐Based Cerebral Perfusion Quantification in Alzheimer's Disease (2024)
Journal Article
Li, R., Zhuo, Z., Hong, Y., Yao, Z., Li, Z., Wang, Y., Jiang, J., Wang, L., Jia, Z., Sun, M., Zhang, Y., Li, W., Ren, Q., Zhang, Y., Duan, Y., Liu, Y., Wei, H., Zhang, Y., Chappell, M., Shi, H., …Xu, J. (2024). Effects of the Fasting‐Postprandial State on Arterial Spin Labeling MRI‐Based Cerebral Perfusion Quantification in Alzheimer's Disease. Journal of Magnetic Resonance Imaging, 60(5), 2173-2183. https://doi.org/10.1002/jmri.29348

Background
The fasting-postprandial state remains an underrecognized confounding factor for quantifying cerebral blood flow (CBF) in the cognitive assessment and differential diagnosis of Alzheimer's disease (AD).

Purpose
To investigate the effe... Read More about Effects of the Fasting‐Postprandial State on Arterial Spin Labeling MRI‐Based Cerebral Perfusion Quantification in Alzheimer's Disease.