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Outputs (189)

Light Cannabis Use and the Adolescent Brain: An 8-years Longitudinal Assessment of Mental Health, Cognition, and Reward Processing. (2024)
Journal Article
Macedo, I., Paiva, T. O., Pasion, R., Daedelow, L., Heinz, A., Magalhães, A., Banaschewski, T., Bokde, A. L., Desrivières, S., Flor, H., Grigis, A., Garavan, H., Gowland, P., Brühl, R., Martinot, J.-L., Martinot, M.-L. P., Artiges, E., Nees, F., Orfanos, D. P., Paus, T., …Barbosa, F. (2024). Light Cannabis Use and the Adolescent Brain: An 8-years Longitudinal Assessment of Mental Health, Cognition, and Reward Processing. Psychopharmacology, 241, 1447-1461. https://doi.org/10.1007/s00213-024-06575-z

Rationale: For decades, cannabis has been the most widely used illicit substance in the world, particularly among youth. Research suggests that mental health problems associated with cannabis use may result from its effect on reward brain circuit, em... Read More about Light Cannabis Use and the Adolescent Brain: An 8-years Longitudinal Assessment of Mental Health, Cognition, and Reward Processing..

Improvements in Between-Vendor MRI Harmonization of Renal T2 Mapping using Stimulated Echo Compensation (2024)
Journal Article
Li, H., Daniel, A. J., Buchanan, C. E., Nery, F., Morris, D. M., Li, S., Huang, Y., Sousa, J. A., Sourbron, S., Mendichovszky, I. A., Thomas, D. L., Priest, A. N., & Francis, S. T. (2024). Improvements in Between-Vendor MRI Harmonization of Renal T2 Mapping using Stimulated Echo Compensation. Journal of Magnetic Resonance Imaging, 60(5), 2144-2155. https://doi.org/10.1002/jmri.29282

Background: T2 mapping is valuable to evaluate pathophysiology in kidney disease. However, variations in T2 relaxation time measurements across MR scanners and vendors may occur requiring additional correction. Purpose: To harmonize renal T2 measurem... Read More about Improvements in Between-Vendor MRI Harmonization of Renal T2 Mapping using Stimulated Echo Compensation.

Bed‐rest and exercise remobilization: Concurrent adaptations in muscle glucose and protein metabolism (2024)
Journal Article
Shur, N. F., Simpson, E. J., Crossland, H., Constantin, D., Cordon, S. M., Constantin-Teodosiu, D., Stephens, F. B., Brook, M. S., Atherton, P. J., Smith, K., Wilkinson, D. J., Mougin, O. E., Bradley, C., Macdonald, I. A., & Greenhaff, P. L. (2024). Bed‐rest and exercise remobilization: Concurrent adaptations in muscle glucose and protein metabolism. Journal of Cachexia, Sarcopenia and Muscle, 15(2), 603-614. https://doi.org/10.1002/jcsm.13431

Background
Bed-rest (BR) of only a few days duration reduces muscle protein synthesis and induces skeletal muscle atrophy and insulin resistance, but the scale and juxtaposition of these events have not been investigated concurrently in the same ind... Read More about Bed‐rest and exercise remobilization: Concurrent adaptations in muscle glucose and protein metabolism.

Mechanisms underlying the laxative effect of lactulose: A randomized placebo‐controlled trial showing increased small bowel water and motility unaltered by the 5‐HT3 receptor antagonist, ondansetron (2024)
Journal Article
Gunn, D., Yeldho, C., Hoad, C., Menys, A., Gowland, P., Marciani, L., & Spiller, R. (in press). Mechanisms underlying the laxative effect of lactulose: A randomized placebo‐controlled trial showing increased small bowel water and motility unaltered by the 5‐HT3 receptor antagonist, ondansetron. Neurogastroenterology and Motility, https://doi.org/10.1111/nmo.14754

Background: Lactulose is a laxative which accelerates transit and softens stool. Our aim was to investigate its mechanism of action and use this model of diarrhea to investigate the anti-diarrheal actions of ondansetron.
Methods: A double-blind, ra... Read More about Mechanisms underlying the laxative effect of lactulose: A randomized placebo‐controlled trial showing increased small bowel water and motility unaltered by the 5‐HT3 receptor antagonist, ondansetron.

An examination of resting-state functional connectivity in patients with active Crohn’s disease (2023)
Journal Article
Thapaliya, G., Eldeghaidy, S., Radford, S. J., Francis, S. T., & Moran, G. W. (in press). An examination of resting-state functional connectivity in patients with active Crohn’s disease. Frontiers in Neuroscience, 17, Article 1265815. https://doi.org/10.3389/fnins.2023.1265815

Background: Alterations in resting state functional connectivity (rs-FC) in Crohn’s Disease (CD) have been documented in default mode network (DMN) and frontal parietal network (FPN) areas, visual, cerebellar, salience and attention resting-state-net... Read More about An examination of resting-state functional connectivity in patients with active Crohn’s disease.

An examination of resting-state functional connectivity in patients with active Crohn's disease (2023)
Journal Article
Francis, S. T., Moran, G. W., Eldeghaidy, S., Radford, S., & Thapaliya, G. (2023). An examination of resting-state functional connectivity in patients with active Crohn's disease. Frontiers in Neuroscience, 17, Article 1265815. https://doi.org/10.3389/fnins.2023.1265815

Background: Alterations in resting state functional connectivity (rs-FC) in Crohn’s Disease (CD) have been documented in default mode network (DMN) and frontal parietal network (FPN) areas, visual, cerebellar, salience and attention resting-state-net... Read More about An examination of resting-state functional connectivity in patients with active Crohn's disease.

Two-Dimensional Population Receptive Field Mapping of Human Primary Somatosensory Cortex (2023)
Journal Article
Asghar, M., Sanchez-Panchuelo, R., Schluppeck, D., & Francis, S. (2023). Two-Dimensional Population Receptive Field Mapping of Human Primary Somatosensory Cortex. Brain Topography, 36, 816-834. https://doi.org/10.1007/s10548-023-01000-8

Functional magnetic resonance imaging can provide detailed maps of how sensory space is mapped in the human brain. Here, we use a novel 16 stimulator setup (a 4 × 4 grid) to measure two-dimensional sensory maps of between and within-digit (D2–D4) spa... Read More about Two-Dimensional Population Receptive Field Mapping of Human Primary Somatosensory Cortex.