Recommendations for quantitative cerebral perfusion MRI using multi‐timepoint arterial spin labeling: Acquisition, quantification, and clinical applications

Woods, Joseph G.; Achten, Eric; Asllani, Iris; Bolar, Divya S.; Dai, Weiying; Detre, John A.; Fan, Audrey P.; Fernández‐Seara, María A.; Golay, Xavier; Günther, Matthias; Guo, Jia; Hernandez‐Garcia, Luis; Ho, Mai‐Lan; Juttukonda, Meher R.; Lu, Hanzhang; MacIntosh, Bradley J.; Madhuranthakam, Ananth J.; Mutsaerts, Henk‐Jan; Okell, Thomas W.; Parkes, Laura M.; Pinter, Nandor; Pinto, Joana; Qin, Qin; Smits, Marion; Suzuki, Yuriko; Thomas, David L.; Van Osch, Matthias J. P.; Wang, Danny J. J.; Warnert, Esther A. H.; Zaharchuk, Greg; Zelaya, Fernando; Zhao, Moss; Chappell, Michael A.; the ISMRM Perfusion Study Group

Abstract

Accurate assessment of cerebral perfusion is vital for understanding the hemodynamic processes involved in various neurological disorders and guiding clinical decision-making. This guidelines article provides a comprehensive overview of quantitative perfusion imaging of the brain using multi-timepoint arterial spin labeling (ASL), along with recommendations for its acquisition and quantification. A major benefit of acquiring ASL data with multiple label durations and/or post-labeling delays (PLDs) is being able to account for the effect of variable arterial transit time (ATT) on quantitative perfusion values and additionally visualize the spatial pattern of ATT itself, providing valuable clinical insights. Although multi-timepoint data can be acquired in the same scan time as single-PLD data with comparable perfusion measurement precision, its acquisition and postprocessing presents challenges beyond single-PLD ASL, impeding widespread adoption. Building upon the 2015 ASL consensus article, this work highlights the protocol distinctions specific to multi-timepoint ASL and provides robust recommendations for acquiring high-quality data. Additionally, we propose an extended quantification model based on the 2015 consensus model and discuss relevant postprocessing options to enhance the analysis of multi-timepoint ASL data. Furthermore, we review the potential clinical applications where multi-timepoint ASL is expected to offer significant benefits. This article is part of a series published by the International Society for Magnetic Resonance in Medicine (ISMRM) Perfusion Study Group, aiming to guide and inspire the advancement and utilization of ASL beyond the scope of the 2015 consensus article.

Citation

Woods, J. G., Achten, E., Asllani, I., Bolar, D. S., Dai, W., Detre, J. A., Fan, A. P., Fernández‐Seara, M. A., Golay, X., Günther, M., Guo, J., Hernandez‐Garcia, L., Ho, M., Juttukonda, M. R., Lu, H., MacIntosh, B. J., Madhuranthakam, A. J., Mutsaerts, H., Okell, T. W., Parkes, L. M., …the ISMRM Perfusion Study Group. (2024). Recommendations for quantitative cerebral perfusion MRI using multi‐timepoint arterial spin labeling: Acquisition, quantification, and clinical applications. Magnetic Resonance in Medicine, 92(2), 469-495. https://doi.org/10.1002/mrm.30091

• Journal Article Type: Article
• Acceptance Date: Mar 7, 2024
• Online Publication Date: Apr 9, 2024
• Publication Date: 2024-08
• Deposit Date: Apr 15, 2024
• Publicly Available Date: Apr 16, 2024
• Journal: Magnetic Resonance in Medicine
• Print ISSN: 0740-3194
• Electronic ISSN: 1522-2594
• Publisher: Wiley
• Peer Reviewed: Peer Reviewed
• Volume: 92
• Issue: 2
• Pages: 469-495
• DOI: https://doi.org/10.1002/mrm.30091
• Keywords: Arterial spin labeling; arterial transit time; cerebral blood flow; multi-timepoint; perfusion
• Public URL: https://nottingham-repository.worktribe.com/output/33567386
• Publisher URL: https://onlinelibrary.wiley.com/doi/10.1002/mrm.30091