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An examination of resting-state functional connectivity in patients with active Crohn’s disease

Thapaliya, Gita; Eldeghaidy, Sally; Radford, Shellie J.; Francis, Susan T.; Moran, Gordon William

An examination of resting-state functional connectivity in patients with active Crohn’s disease Thumbnail


Authors

Gita Thapaliya

GORDON MORAN GORDON.MORAN@NOTTINGHAM.AC.UK
Professor of Gastroenterology



Abstract

Background: Alterations in resting state functional connectivity (rs-FC) in Crohn’s Disease (CD) have been documented in default mode network (DMN) and frontal parietal network (FPN) areas, visual, cerebellar, salience and attention resting-state-networks (RSNs), constituting a CD specific neural phenotype. To date, most studies are in patients in remission, with limited studies in active disease. Methods: Twenty five active CD cases and 25 age-, BMI- and gender-matched healthy controls (HC) were recruited to a resting-state-functional Magnetic Resonance Imaging (rs-fMRI) study. Active disease was defined as C-reactive protein>5 mg/dL, faecal calprotectin>250 μg/g, or through ileocolonoscopy or MRE. rs-fMRI data were analysed using independent component analysis (ICA) and dual regression. Differences in RSNs between HCs and active CD were assessed, and rs-FC was associated with disease duration and abdominal pain. Results: Increased connectivity in the FPN (fusiform gyrus, thalamus, caudate, posterior cingulate cortex, postcentral gyrus) and visual RSN (orbital frontal cortex) were observed in CD versus HC. Decreased activity was observed in the salience network (cerebellum, postcentral gyrus), DMN (parahippocampal gyrus, cerebellum), and cerebellar network (occipital fusiform gyrus, cerebellum) in CD versus HCs. Greater abdominal pain scores were associated with lower connectivity in the precuneus (visual network) and parietal operculum (salience network), and higher connectivity in the cerebellum (frontal network). Greater disease duration was associated with greater connectivity in the middle temporal gyrus and planum temporale (visual network). Conclusion: Alterations in rs-FC in active CD in RSNs implicated in cognition, attention, emotion, and pain may represent neural correlates of chronic systemic inflammation, abdominal pain, disease duration, and severity.

Citation

Thapaliya, G., Eldeghaidy, S., Radford, S. J., Francis, S. T., & Moran, G. W. (in press). An examination of resting-state functional connectivity in patients with active Crohn’s disease. Frontiers in Neuroscience, 17, Article 1265815. https://doi.org/10.3389/fnins.2023.1265815

Journal Article Type Article
Acceptance Date Nov 20, 2023
Online Publication Date Dec 6, 2023
Deposit Date Nov 21, 2023
Publicly Available Date Nov 22, 2023
Journal Frontiers in Neuroscience
Print ISSN 1662-4548
Electronic ISSN 1662-453X
Publisher Frontiers Media
Peer Reviewed Peer Reviewed
Volume 17
Article Number 1265815
DOI https://doi.org/10.3389/fnins.2023.1265815
Keywords Crohn's disease, gut-brain axis, Gut Inflammation, systemic inflammation, functional connectivity
Public URL https://nottingham-repository.worktribe.com/output/27588593

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Publisher Licence URL
https://creativecommons.org/licenses/by/4.0/

Copyright Statement
© 2023 Thapaliya, Eldeghaidy, Radford, Francis and Moran. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.





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