Prior Consumption of a Fat Meal in Healthy Adults Modulates the Brain's Response to Fat

Eldeghaidy, Sally; Marciani, Luca; Hort, Joanne; Hollowood, Tracey Ann; Singh, Gulzar; Bush, Debbie; Foster, Tim; Taylor, Andrew J.; Busch, Johanneke; Spiller, Robin C.; Gowland, Penny A.; Francis, Susan T.

Abstract

Background: Consumption of fat is regulated by reward and homeostatic pathways, but no studies have examined the role of the intake of a high fat meal (HFM) on subsequent brain activation to oral stimuli.
Objective: We evaluated how prior consumption of a HFM or water load (WL) modulates reward, homeostatic and taste brain responses to subsequent delivery of oral fat.
Methods: A randomized 2-way crossover design (1-week apart) was used to compare prior consumption of a 250mL HFM (520kcal) (rapeseed oil (440kcal), emulsifier, sucrose, flavor cocktail) or non-caloric WL on brain activation to the delivery of repeated trials of an oral flavored no-fat control stimulus (CS) or flavored fat stimulus (FS) in 17 healthy adults (11 male, age=25±2 years, BMI=22.4±0.8kg/m2). Analyses tested differences in brain activation to the CS and FS, and baseline cerebral blood flow (CBF), following the HFM and WL. Individual’s plasma cholecystokinin (CCK) concentration following the HFM was correlated with their BOLD activation.
Results: Prior consumption of the HFM compared to the WL led to decreased anterior insula taste activation in response to both the CS (36.3%,P

Citation

Eldeghaidy, S., Marciani, L., Hort, J., Hollowood, T. A., Singh, G., Bush, D., …Francis, S. T. (2016). Prior Consumption of a Fat Meal in Healthy Adults Modulates the Brain's Response to Fat. Journal of Nutrition, 146(11), 2187-2198. https://doi.org/10.3945/jn.116.234104

• Journal Article Type: Article
• Acceptance Date: Aug 12, 2016
• Online Publication Date: Sep 21, 2016
• Publication Date: Nov 1, 2016
• Deposit Date: Sep 22, 2016
• Publicly Available Date: Sep 22, 2016
• Journal: The Journal of Nutrition
• Print ISSN: 0022-3166
• Electronic ISSN: 1541-6100
• Publisher: Oxford University Press
• Peer Reviewed: Peer Reviewed
• Volume: 146
• Issue: 11
• Pages: 2187-2198
• DOI: https://doi.org/10.3945/jn.116.234104
• Keywords: fMRI, BOLD, CBF, CCK, habituation, oral fat, insula, subjective rating satiety
• Public URL: https://nottingham-repository.worktribe.com/output/809939
• Publisher URL: http://jn.nutrition.org/content/early/2016/09/20/jn.116.234104