Consensus-based technical recommendations for clinical translation of renal ASL MRI
Dr CHARLOTTE BUCHANAN CHARLOTTE.BUCHANAN@NOTTINGHAM.AC.UK
Anita A Harteveld
ELEANOR COX ELEANOR.COX@NOTTINGHAM.AC.UK
Senior Research Fellow
H Michael Gach
Ananth J Madhuranthakam
Pottumarthi V Prasad
Philip M Robson
David L Thomas
Danny J J Wang
Jeff L Zhang
David C Alsop
Sean B Fain
Professor SUSAN FRANCIS email@example.com
Professor of Physics
Objectives: To develop technical recommendations for the acquisition, processing and analysis of renal ASL data in the human kidney at 1.5T and 3T field strengths that can promote standardization of renal perfusion measurements and facilitate the comparability of results across scanners and in multi-center clinical studies.
Methods: An international panel of 23 renal ASL experts followed a modified Delphi process, including on-line surveys and two in-person meetings, to formulate a series of consensus statements regarding patient preparation, hardware, acquisition protocol, analysis steps and data reporting.
Results: Fifty-nine statements achieved consensus, while agreement could not be reached on two statements related to patient preparation. As a default protocol, the panel recommends pseudo-continuous (PCASL) or flow-sensitive alternating inversion recovery (FAIR) labeling with a single-slice spin-echo EPI readout with background suppression, and a simple but robust quantification model.
Discussion: This approach is considered robust and reproducible and can provide renal perfusion images of adequate quality and SNR for most applications. If extended kidney coverage is desirable, a 2D multislice readout is recommended. These recommendations are based on current available evidence and expert opinion. Nonetheless they are expected to be updated as more data becomes available, since the renal ASL literature is rapidly expanding.
Nery, F., Buchanan, C. E., Harteveld, A. A., Odudu, A., Bane, O., Cox, E. F., …Fernández-Seara, M. A. (2020). Consensus-based technical recommendations for clinical translation of renal ASL MRI. Magnetic Resonance Materials in Physics, Biology and Medicine, 33(1), 141-161. https://doi.org/10.1007/s10334-019-00800-z
|Journal Article Type||Article|
|Acceptance Date||Nov 11, 2019|
|Online Publication Date||Dec 12, 2019|
|Deposit Date||Jan 2, 2020|
|Publicly Available Date||Jan 14, 2020|
|Journal||Magnetic Resonance Materials in Physics, Biology and Medicine|
|Peer Reviewed||Peer Reviewed|
|Keywords||Biophysics; Radiological and Ultrasound Technology; Radiology Nuclear Medicine and imaging|
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