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Consensus-based technical recommendations for clinical translation of renal ASL MRI

Consensus-based technical recommendations for clinical translation of renal ASL MRI Thumbnail


Fabio Nery

Anita A Harteveld

Aghogho Odudu

Octavia Bane

Senior Research Fellow

Katja Derlin

H Michael Gach

Xavier Golay

Marcel Gutberlet

Christoffer Laustsen

Alexandra Ljimani

Ananth J Madhuranthakam

Ivan Pedrosa

Pottumarthi V Prasad

Philip M Robson

Kanishka Sharma

Steven Sourbron

Manuel Taso

David L Thomas

Danny J J Wang

Jeff L Zhang

David C Alsop

Sean B Fain


Objectives: To develop technical recommendations for the acquisition, processing and analysis of renal ASL data in the human kidney at 1.5T and 3T field strengths that can promote standardization of renal perfusion measurements and facilitate the comparability of results across scanners and in multi-center clinical studies.
Methods: An international panel of 23 renal ASL experts followed a modified Delphi process, including on-line surveys and two in-person meetings, to formulate a series of consensus statements regarding patient preparation, hardware, acquisition protocol, analysis steps and data reporting.
Results: Fifty-nine statements achieved consensus, while agreement could not be reached on two statements related to patient preparation. As a default protocol, the panel recommends pseudo-continuous (PCASL) or flow-sensitive alternating inversion recovery (FAIR) labeling with a single-slice spin-echo EPI readout with background suppression, and a simple but robust quantification model.
Discussion: This approach is considered robust and reproducible and can provide renal perfusion images of adequate quality and SNR for most applications. If extended kidney coverage is desirable, a 2D multislice readout is recommended. These recommendations are based on current available evidence and expert opinion. Nonetheless they are expected to be updated as more data becomes available, since the renal ASL literature is rapidly expanding.


Nery, F., Buchanan, C. E., Harteveld, A. A., Odudu, A., Bane, O., Cox, E. F., …Fernández-Seara, M. A. (2020). Consensus-based technical recommendations for clinical translation of renal ASL MRI. Magnetic Resonance Materials in Physics, Biology and Medicine, 33(1), 141-161.

Journal Article Type Article
Acceptance Date Nov 11, 2019
Online Publication Date Dec 12, 2019
Publication Date 2020-02
Deposit Date Jan 2, 2020
Publicly Available Date Jan 14, 2020
Journal Magnetic Resonance Materials in Physics, Biology and Medicine
Print ISSN 0968-5243
Electronic ISSN 1352-8661
Publisher Springer Verlag
Peer Reviewed Peer Reviewed
Volume 33
Issue 1
Pages 141-161
Keywords Biophysics; Radiological and Ultrasound Technology; Radiology Nuclear Medicine and imaging
Public URL
Publisher URL


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