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Consensus-based technical recommendations for clinical translation of renal T1 and T2 mapping MRI

Semple, Scott I. K.; Dekkers, Ilona A.; de Boer, Anneloes; Sharma, Kaniska; Cox, Eleanor F.; Lamb, Hildo J.; Buckley, David L.; Bane, Octavia; Morris, David M.; Prasad, Pottumarthi V.; Semple, Scott I.K.; Gillis, Keith A.; Hockings, Paul; Buchanan, Charlotte; Wolf, Marcos; Laustsen, Christoffer; Leiner, Tim; Haddock, Bryan; Hoogduin, Johannes M.; Pullens, Pim; Sourbron, Steven; Francis, Susan

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Scott I. K. Semple

Ilona A. Dekkers

Anneloes de Boer

Kaniska Sharma

Senior Research Fellow

Hildo J. Lamb

David L. Buckley

Octavia Bane

David M. Morris

Pottumarthi V. Prasad

Scott I.K. Semple

Keith A. Gillis

Paul Hockings

Marcos Wolf

Christoffer Laustsen

Tim Leiner

Bryan Haddock

Johannes M. Hoogduin

Pim Pullens

Steven Sourbron


© 2019, The Author(s). To develop technical recommendations on the acquisition and post-processing of renal longitudinal (T1) and transverse (T2) relaxation time mapping. A multidisciplinary panel consisting of 18 experts in the field of renal T1 and T2 mapping participated in a consensus project, which was initiated by the European Cooperation in Science and Technology Action PARENCHIMA CA16103. Consensus recommendations were formulated using a two-step modified Delphi method. The first survey consisted of 56 items on T1 mapping, of which 4 reached the pre-defined consensus threshold of 75% or higher. The second survey was expanded to include both T1 and T2 mapping, and consisted of 54 items of which 32 reached consensus. Recommendations based were formulated on hardware, patient preparation, acquisition, analysis and reporting. Consensus-based technical recommendations for renal T1 and T2 mapping were formulated. However, there was considerable lack of consensus for renal T1 and particularly renal T2 mapping, to some extent surprising considering the long history of relaxometry in MRI, highlighting key knowledge gaps that require further work. This paper should be regarded as a first step in a long-term evidence-based iterative process towards ever increasing harmonization of scan protocols across sites, to ultimately facilitate clinical implementation.


Semple, S. I. K., Dekkers, I. A., de Boer, A., Sharma, K., Cox, E. F., Lamb, H. J., …Francis, S. (2020). Consensus-based technical recommendations for clinical translation of renal T1 and T2 mapping MRI. Magnetic Resonance Materials in Physics, Biology and Medicine, 33(1), 163-176.

Journal Article Type Article
Acceptance Date Nov 4, 2019
Online Publication Date Nov 22, 2019
Publication Date 2020-02
Deposit Date Jan 2, 2020
Publicly Available Date Jan 8, 2020
Journal Magnetic Resonance Materials in Physics, Biology and Medicine
Print ISSN 0968-5243
Electronic ISSN 1352-8661
Publisher Springer Verlag
Peer Reviewed Peer Reviewed
Volume 33
Issue 1
Pages 163-176
Keywords Biophysics; Radiological and Ultrasound Technology; Radiology Nuclear Medicine and imaging
Public URL
Publisher URL
Additional Information Received: 8 August 2019; Revised: 31 October 2019; Accepted: 4 November 2019; First Online: 22 November 2019; : ; : Author P.H. is director of Imaging at Antaros Medical. Other authors declare no conflict of interest.; : Informed consent was obtained from all individual participants included in the study.