Consensus-based technical recommendations for clinical translation of renal diffusion-weighted MRI

Ljimani, Alexandra; Caroli, Anna; Laustsen, Christoffer; Francis, Susan; Mendichovszky, Iosif Alexandru; Bane, Octavia; Nery, Fabio; Sharma, Kanishka; Pohlmann, Andreas; Dekkers, Ilona A.; Vallee, Jean-Paul; Derlin, Katja; Notohamiprodjo, Mike; Lim, Ruth P.; Palmucci, Stefano; Serai, Suraj D.; Periquito, Joao; Wang, Zhen Jane; Froeling, Martijn; Thoeny, Harriet C.; Prasad, Pottumarthi; Schneider, Moritz; Niendorf, Thoralf; Pullens, Pim; Sourbron, Steven; Sigmund, Eric E.

Abstract

© 2019, European Society for Magnetic Resonance in Medicine and Biology (ESMRMB). Objectives: Standardization is an important milestone in the validation of DWI-based parameters as imaging biomarkers for renal disease. Here, we propose technical recommendations on three variants of renal DWI, monoexponential DWI, IVIM and DTI, as well as associated MRI biomarkers (ADC, D, D*, f, FA and MD) to aid ongoing international efforts on methodological harmonization. Materials and methods: Reported DWI biomarkers from 194 prior renal DWI studies were extracted and Pearson correlations between diffusion biomarkers and protocol parameters were computed. Based on the literature review, surveys were designed for the consensus building. Survey data were collected via Delphi consensus process on renal DWI preparation, acquisition, analysis, and reporting. Consensus was defined as ≥ 75% agreement. Results: Correlations were observed between reported diffusion biomarkers and protocol parameters. Out of 87 survey questions, 57 achieved consensus resolution, while many of the remaining questions were resolved by preference (65–74% agreement). Summary of the literature and survey data as well as recommendations for the preparation, acquisition, processing and reporting of renal DWI were provided. Discussion: The consensus-based technical recommendations for renal DWI aim to facilitate inter-site harmonization and increase clinical impact of the technique on a larger scale by setting a framework for acquisition protocols for future renal DWI studies. We anticipate an iterative process with continuous updating of the recommendations according to progress in the field.

Citation

Ljimani, A., Caroli, A., Laustsen, C., Francis, S., Mendichovszky, I. A., Bane, O., Nery, F., Sharma, K., Pohlmann, A., Dekkers, I. A., Vallee, J.-P., Derlin, K., Notohamiprodjo, M., Lim, R. P., Palmucci, S., Serai, S. D., Periquito, J., Wang, Z. J., Froeling, M., Thoeny, H. C., …Sigmund, E. E. (2020). Consensus-based technical recommendations for clinical translation of renal diffusion-weighted MRI. Magnetic Resonance Materials in Physics, Biology and Medicine, 33, 177-195. https://doi.org/10.1007/s10334-019-00790-y

• Journal Article Type: Article
• Acceptance Date: Oct 30, 2019
• Online Publication Date: Nov 1, 2019
• Publication Date: Feb 1, 2020
• Deposit Date: Jan 2, 2020
• Publicly Available Date: Nov 2, 2020
• Journal: Magnetic Resonance Materials in Physics, Biology and Medicine
• Print ISSN: 0968-5243
• Electronic ISSN: 1352-8661
• Publisher: Springer Verlag
• Peer Reviewed: Peer Reviewed
• Volume: 33
• Pages: 177-195
• DOI: https://doi.org/10.1007/s10334-019-00790-y
• Keywords: Biophysics; Radiological and Ultrasound Technology; Radiology Nuclear Medicine and imaging
• Public URL: https://nottingham-repository.worktribe.com/output/3655792
• Publisher URL: https://link.springer.com/article/10.1007/s10334-019-00790-y
• Additional Information: This is a post-peer-review, pre-copyedit version of an article published in Magnetic Resonance Materials in Physics, Biology and Medicine. The final authenticated version is available online at: http://dx.doi.org/10.1007/s10334-019-00790-y