All Outputs (19)

Long-Term Connectome Analysis Reveals Reshaping of Visual, Spatial Networks in a Model With Vascular Dementia Features (2022)
Journal Article

Background: Connectome analysis of neuroimaging data is a rapidly expanding field that offers the potential to diagnose, characterize, and predict neurological disease. Animal models provide insight into biological mechanisms that underpin disease, b... Read More about Long-Term Connectome Analysis Reveals Reshaping of Visual, Spatial Networks in a Model With Vascular Dementia Features.

Structures of the Human SPAK and OSR1 Conserved C-Terminal (CCT) Domains (2021)
Journal Article

STE20/SPS1-related proline/alanine-rich kinase (SPAK) and oxidative stress responsive 1 (OSR1) kinase are two serine/threonine protein kinases that regulate the function of ion co-transporters through phosphorylation. The highly conserved C-terminal... Read More about Structures of the Human SPAK and OSR1 Conserved C-Terminal (CCT) Domains.

Glyceryl trinitrate for the treatment of ischaemic stroke: Determining efficacy in rodent and ovine species for enhanced clinical translation (2021)
Journal Article

Hypertension is a leading risk factor for death and dependency after ischaemic stroke. However, administering anti-hypertensive medications post-stroke remains contentious with concerns regarding deleterious effects on cerebral blood flow and infarct... Read More about Glyceryl trinitrate for the treatment of ischaemic stroke: Determining efficacy in rodent and ovine species for enhanced clinical translation.

A pilot of the feasibility and usefulness of an aged obese model for use in stroke research (2021)
Journal Article

Background: Animal models of stroke have been criticised as having poor predictive validity, lacking risk factors prevalent in an aging population. This pilot study examined the development of comorbidities in a combined aged and high-fat diet model,... Read More about A pilot of the feasibility and usefulness of an aged obese model for use in stroke research.

CDK12 inhibition reduces abnormalities in cells from patients with myotonic dystrophy and in a mouse model (2020)
Journal Article

Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Myotonic dystrophy type 1 (DM1) is an RNA-based disease with no current treatment.... Read More about CDK12 inhibition reduces abnormalities in cells from patients with myotonic dystrophy and in a mouse model.

UK consensus on pre-clinical vascular cognitive impairment functional outcomes assessment: questionnaire and workshop proceedings (2020)
Journal Article

© The Author(s) 2020. Assessment of outcome in preclinical studies of vascular cognitive impairment (VCI) is heterogenous. Through an ARUK Scottish Network supported questionnaire and workshop (mostly UK-based researchers), we aimed to determine unde... Read More about UK consensus on pre-clinical vascular cognitive impairment functional outcomes assessment: questionnaire and workshop proceedings.

Recommendations for measuring whisker movements and locomotion in mice with sensory, motor and cognitive deficits (2019)
Journal Article

Background : Previous studies have measured whisker movements and locomotion to characterise mouse models of neurodegenerative disease. However, these studies have always been completed in isolation, and do not involve standardized procedures for com... Read More about Recommendations for measuring whisker movements and locomotion in mice with sensory, motor and cognitive deficits.

Small vessels, dementia and chronic diseases – molecular mechanisms and pathophysiology (2018)
Journal Article

Cerebral small vessel disease (SVD) is a major contributor to stroke, cognitive impairment and dementia with limited therapeutic interventions. There is a critical need to provide mechanistic insight and improve translation between pre-clinical resea... Read More about Small vessels, dementia and chronic diseases – molecular mechanisms and pathophysiology.

The IMPROVE guidelines (Ischaemia Models: Procedural Refinements Of in Vivo Experiments) (2017)
Journal Article

Most in vivo models of ischaemic stroke target the middle cerebral artery and a spectrum of stroke severities, from mild to substantial, can be achieved. This review describes opportunities to improve the in vivo modelling of ischaemic stroke and ani... Read More about The IMPROVE guidelines (Ischaemia Models: Procedural Refinements Of in Vivo Experiments).

Behavioral outcome measures to improve experimental stroke research (2017)
Journal Article

Functional recovery after an experimental stroke can be assessed by multiple behavioural tests, however, there is no consensus about which test to use in long-term stroke recovery studies or whether the tests are affected by stroke surgery, post-oper... Read More about Behavioral outcome measures to improve experimental stroke research.

Infections up to 76 days after stroke increase disability and death (2017)
Journal Article

Early infection after stroke is associated with a poor outcome. We aimed to determine whether delayed infections (up to 76 days post-stroke) are associated with poor outcome at 90 days. Data came from the international Efficacy of Nitric Oxide Stroke... Read More about Infections up to 76 days after stroke increase disability and death.

Neuroimaging biomarkers predict brain structural connectivity change in a mouse model of vascular cognitive impairment (2017)
Journal Article

Background and Purpose�Chronic hypoperfusion in the mouse brain has been suggested to mimic aspects of vascular cognitive impairment, such as white matter damage. Although this model has attracted attention, our group has struggled to generate a reli... Read More about Neuroimaging biomarkers predict brain structural connectivity change in a mouse model of vascular cognitive impairment.

Lickometry: a novel and sensitive method for assessing functional deficits in rats after stroke (2017)
Journal Article

The need for sensitive, easy to administer assessments of long-term functional deficits is crucial in pre-clinical stroke research. In the present study, we introduce lickometry (lick microstructure analysis) as a precise method to assess sensorimoto... Read More about Lickometry: a novel and sensitive method for assessing functional deficits in rats after stroke.

Intra-arterial nitroglycerin as directed acute treatment in experimental ischemic stroke (2016)
Journal Article

Background: Nitroglycerin (also known as glyceryl trinitrate (GTN)), a vasodilator best known for treatment of ischemic heart disease, has also been investigated for its potential therapeutic benefit in ischemic stroke. The completed Efficacy of Nitr... Read More about Intra-arterial nitroglycerin as directed acute treatment in experimental ischemic stroke.

Developing Mn-doped lead sulfide quantum dots for MRI labels (2016)
Journal Article

Magnetic interactions of Mn2+ions in lead sulfide (PbS) nanocrystals with protons in water are probed by NMR and MRI. A thin layer of capping molecules enables free solvent diffusion to the nanocrystal surface resulting in a decrease of proton relaxa... Read More about Developing Mn-doped lead sulfide quantum dots for MRI labels.

Longitudinal in vivo MRI in a Huntington’s disease mouse model: Global atrophy in the absence of white matter microstructural damage (2016)
Journal Article

Huntington’s disease (HD) is a genetically-determined neurodegenerative disease. Characterising neuropathology in mouse models of HD is commonly restricted to cross-sectional ex vivo analyses, beset by tissue fixation issues. In vivo longitudinal mag... Read More about Longitudinal in vivo MRI in a Huntington’s disease mouse model: Global atrophy in the absence of white matter microstructural damage.

Systematic and detailed analysis of behavioural tests in the rat middle cerebral artery occlusion model of stroke: Tests for long-term assessment (2016)
Journal Article

In order to test therapeutics, functional assessments are required. In pre-clinical stroke research, there is little consensus regarding the most appropriate behavioural tasks to assess deficits; especially when testing over extended times in milder... Read More about Systematic and detailed analysis of behavioural tests in the rat middle cerebral artery occlusion model of stroke: Tests for long-term assessment.

In vivo MRI evidence that neuropathology is attenuated by cognitive enrichment in the Yac128 Huntington's disease mouse model (2015)
Journal Article

Robust MR-based approaches to quantifying white matter structure and structure/function alterations in Huntington's disease (2015)
Journal Article