Skip to main content

Research Repository

Advanced Search

Long-term connectome analysis reveals reshaping of visual, spatial networks in a model with vascular dementia features

Hall, Gerard R; Boehm-Sturm, Philipp; Dirnagl, Ulrich; Finke, Carsten; Foddis, Marco; Harms, Christoph; Koch, Stefan Paul; Kuchling, Joseph; Madan, Christopher R; Mueller, Susanne; Sassi, Celeste; Sotiropoulos, Stamatios N; Trueman, Rebecca C; Wallis, Marcus; Yildirim, Ferah; Farr, Tracy D

Authors

Gerard R Hall

Philipp Boehm-Sturm

Ulrich Dirnagl

Carsten Finke

Marco Foddis

Christoph Harms

Stefan Paul Koch

Joseph Kuchling

Susanne Mueller

Celeste Sassi

Stamatios N Sotiropoulos

Marcus Wallis

Ferah Yildirim



Abstract

Background and purpose: Connectome analysis of neuroimaging data is a rapidly expanding field that offers the potential to diagnose, characterise, and predict neurological disease. Animal models provide insight into biological mechanisms that underpin disease, but connectivity approaches are currently lagging in the rodent. Methods: We present a pipeline adapted for structural and functional connectivity analysis of the mouse brain and we tested it in a mouse model of vascular dementia. Results: We observed lacunar infarctions, microbleeds, and progressive white matter change across 6 months. For the first time, we report that default mode network activity is disrupted in the mouse model. We also identified specific functional circuitry that was vulnerable to vascular stress, including perturbations in a sensorimotor, visual resting state network that were accompanied by deficits in visual and spatial memory tasks. Conclusions: These findings advance our understanding of the mouse connectome and provide insight into how it can be altered by vascular insufficiency.

Citation

Hall, G. R., Boehm-Sturm, P., Dirnagl, U., Finke, C., Foddis, M., Harms, C., …Farr, T. D. (in press). Long-term connectome analysis reveals reshaping of visual, spatial networks in a model with vascular dementia features. Stroke,

Journal Article Type Article
Acceptance Date Nov 22, 2021
Deposit Date Nov 26, 2021
Journal Stroke
Print ISSN 0039-2499
Publisher American Heart Association
Peer Reviewed Peer Reviewed
Public URL https://nottingham-repository.worktribe.com/output/6789677