Skip to main content

Research Repository

Advanced Search

Behavioral outcome measures to improve experimental stroke research

Balkaya, Mustafa G.; Trueman, Rebecca C.; Boltze, Johannes; Corbett, Dale; Jolkkonen, Jukka

Authors

Mustafa G. Balkaya

Rebecca C. Trueman

Johannes Boltze

Dale Corbett

Jukka Jolkkonen



Abstract

Functional recovery after an experimental stroke can be assessed by multiple behavioural tests, however, there is no consensus about which test to use in long-term stroke recovery studies or whether the tests are affected by stroke surgery, post-operative care or behavioural compensation due to repeated testing. This review describes the tests most commonly used to assess motor and sensorimotor function, cognition and mood in stroke animals. Although it is difficult to predict the direction of future research, it may be possible to prevent false-positive results by selecting an appropriate task or a battery of tasks. It is also expected that the upcoming stroke recovery recommendations and the improved dialogue between academy, industry and healthcare professionals will further promote translational success.

Citation

Balkaya, M. G., Trueman, R. C., Boltze, J., Corbett, D., & Jolkkonen, J. (in press). Behavioral outcome measures to improve experimental stroke research. Behavioural Brain Research, https://doi.org/10.1016/j.bbr.2017.07.039

Journal Article Type Article
Acceptance Date Jul 27, 2017
Online Publication Date Jul 29, 2017
Deposit Date Sep 15, 2017
Publicly Available Date Sep 15, 2017
Journal Behavioural Brain Research
Print ISSN 0166-4328
Electronic ISSN 1872-7549
Publisher Elsevier
Peer Reviewed Peer Reviewed
DOI https://doi.org/10.1016/j.bbr.2017.07.039
Keywords Stroke, Animal models, Behavioral tests, Sensorimotor function, Cognition, Depression, Anxiety, Restoration
Public URL http://eprints.nottingham.ac.uk/id/eprint/46341
Publisher URL http://www.sciencedirect.com/science/article/pii/S0166432817307325?via%3Dihub
Copyright Statement Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by-nc-nd/4.0

Files

BBR_2017_579_Final.pdf (302 Kb)
PDF

Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by-nc-nd/4.0





You might also like



Downloadable Citations