Behavioral outcome measures to improve experimental stroke research

Balkaya, Mustafa G.; Trueman, Rebecca C.; Boltze, Johannes; Corbett, Dale; Jolkkonen, Jukka

Abstract

Functional recovery after an experimental stroke can be assessed by multiple behavioural tests, however, there is no consensus about which test to use in long-term stroke recovery studies or whether the tests are affected by stroke surgery, post-operative care or behavioural compensation due to repeated testing. This review describes the tests most commonly used to assess motor and sensorimotor function, cognition and mood in stroke animals. Although it is difficult to predict the direction of future research, it may be possible to prevent false-positive results by selecting an appropriate task or a battery of tasks. It is also expected that the upcoming stroke recovery recommendations and the improved dialogue between academy, industry and healthcare professionals will further promote translational success.

Citation

Balkaya, M. G., Trueman, R. C., Boltze, J., Corbett, D., & Jolkkonen, J. (in press). Behavioral outcome measures to improve experimental stroke research. Behavioural Brain Research, https://doi.org/10.1016/j.bbr.2017.07.039

• Journal Article Type: Article
• Acceptance Date: Jul 27, 2017
• Online Publication Date: Jul 29, 2017
• Deposit Date: Sep 15, 2017
• Publicly Available Date: Sep 15, 2017
• Journal: Behavioural Brain Research
• Print ISSN: 0166-4328
• Electronic ISSN: 1872-7549
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• DOI: https://doi.org/10.1016/j.bbr.2017.07.039
• Keywords: Stroke, Animal models, Behavioral tests, Sensorimotor function, Cognition, Depression, Anxiety, Restoration
• Public URL: https://nottingham-repository.worktribe.com/output/874653
• Publisher URL: http://www.sciencedirect.com/science/article/pii/S0166432817307325?via%3Dihub
• Contract Date: Sep 15, 2017