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UK consensus on pre-clinical vascular cognitive impairment functional outcomes assessment: questionnaire and workshop proceedings

McColl, Barry W; Allan, Stuart M; McFall, Aisling; Hietamies, Tuuli M; Bernard, Ashton; Aimable, Margaux; Bath, Philip M; Brezzo, Gaia; Carare, Roxana O; Carswell, Hilary V; Clarkson, Andrew N; Currie, Gillian; Farr, Tracy D; Fowler, Jill; Good, Mark; Hainsworth, Atticus H; Hall, Catherine; Horsburgh, Karen; Kalaria, Rajesh; Kehoe, Patrick; Lawrence, Catherine; Macleod, Malcolm; McNeilly, Alison; Miller, Alyson A; Miners, Scott; Mok, Vincent; O'Sullivan, Michael; Platt, Bettina; Sena, Emily S; Sharp, Matthew; Strangeward, Patrick; Szymkowiak, Stefan; Touyz, Rhian M; Trueman, Rebecca C; White, Claire; McCabe, Chris; Work, Lorraine M; Quinn, Terence J


Barry W McColl

Stuart M Allan

Aisling McFall

Tuuli M Hietamies

Ashton Bernard

Margaux Aimable

Stroke Association Professor of Stroke Medicine

Gaia Brezzo

Roxana O Carare

Hilary V Carswell

Andrew N Clarkson

Gillian Currie

Jill Fowler

Mark Good

Atticus H Hainsworth

Catherine Hall

Karen Horsburgh

Rajesh Kalaria

Patrick Kehoe

Catherine Lawrence

Malcolm Macleod

Alison McNeilly

Alyson A Miller

Scott Miners

Vincent Mok

Michael O'Sullivan

Bettina Platt

Emily S Sena

Matthew Sharp

Patrick Strangeward

Stefan Szymkowiak

Rhian M Touyz

Claire White

Chris McCabe

Lorraine M Work

Terence J Quinn


© The Author(s) 2020. Assessment of outcome in preclinical studies of vascular cognitive impairment (VCI) is heterogenous. Through an ARUK Scottish Network supported questionnaire and workshop (mostly UK-based researchers), we aimed to determine underlying variability and what could be implemented to overcome identified challenges. Twelve UK VCI research centres were identified and invited to complete a questionnaire and attend a one-day workshop. Questionnaire responses demonstrated agreement that outcome assessments in VCI preclinical research vary by group and even those common across groups, may be performed differently. From the workshop, six themes were discussed: issues with preclinical models, reasons for choosing functional assessments, issues in interpretation of functional assessments, describing and reporting functional outcome assessments, sharing resources and expertise, and standardization of outcomes. Eight consensus points emerged demonstrating broadly that the chosen assessment should reflect the deficit being measured, and therefore that one assessment does not suit all models; guidance/standardisation on recording VCI outcome reporting is needed and that uniformity would be aided by a platform to share expertise, material, protocols and procedures thus reducing heterogeneity and so increasing potential for collaboration, comparison and replication. As a result of the workshop, UK wide consensus statements were agreed and future priorities for preclinical research identified.


McColl, B. W., Allan, S. M., McFall, A., Hietamies, T. M., Bernard, A., Aimable, M., …Quinn, T. J. (2020). UK consensus on pre-clinical vascular cognitive impairment functional outcomes assessment: questionnaire and workshop proceedings. Journal of Cerebral Blood Flow and Metabolism, 40(7), 1402-1414.

Journal Article Type Article
Acceptance Date Dec 6, 2019
Online Publication Date Mar 9, 2020
Publication Date Jul 1, 2020
Deposit Date Dec 16, 2019
Publicly Available Date Mar 9, 2020
Journal Journal of Cerebral Blood Flow and Metabolism
Print ISSN 0271-678X
Electronic ISSN 1559-7016
Publisher SAGE Publications
Peer Reviewed Peer Reviewed
Volume 40
Issue 7
Pages 1402-1414
Keywords Neurology; Clinical Neurology; Cardiology and Cardiovascular Medicine
Public URL
Publisher URL


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