All Outputs (14)

A collagen hydrolysate/milk protein-blend stimulates muscle anabolism equivalently to an isoenergetic milk protein-blend containing a greater quantity of essential amino acids in older men (2021)
Journal Article

Background & aims: Nutritional composition is key for skeletal muscle maintenance into older age. Yet the acute effects of collagen protein blended with other protein sources, in relation to skeletal muscle anabolism, are ill-defined. We investigated... Read More about A collagen hydrolysate/milk protein-blend stimulates muscle anabolism equivalently to an isoenergetic milk protein-blend containing a greater quantity of essential amino acids in older men.

Genetic predisposition to hypertension is associated with preeclampsia in European and Central Asian women (2020)
Journal Article

Hydrostatic pressure regulates CYP1A2 expression in human hepatocytes via a mechanosensitive aryl hydrocarbon receptor-dependent pathway (2020)
Journal Article

Approximately 75% of xenobiotics are primarily eliminated through metabolism; thus the accurate scaling of metabolic clearance is vital to successful drug development. Yet, when data is scaled from in vitro to in vivo, hepatic metabolic clearance, th... Read More about Hydrostatic pressure regulates CYP1A2 expression in human hepatocytes via a mechanosensitive aryl hydrocarbon receptor-dependent pathway.

Elevated 5hmC levels characterize DNA of the cerebellum in Parkinson’s disease (2017)
Journal Article

5-methylcytosine and the oxidation product 5-hydroxymethylcytosine are two prominent epigenetic variants of the cytosine base in nuclear DNA of mammalian brains. We measured levels of 5-methylcytosine and 5-hydroxymethylcytosine by enzyme-linked immu... Read More about Elevated 5hmC levels characterize DNA of the cerebellum in Parkinson’s disease.

Physical and biological characteristics of multi drug resistance (MDR): an integral approach considering pH and drug resistance in cancer (2017)
Journal Article

The role of the Warburg effect in cancer remains to be elucidated with a resurgence in research efforts over the past decade. Why a cancer cell would prefer to use energy inefficient glycolysis, leading to an alteration of pH both inside and outside... Read More about Physical and biological characteristics of multi drug resistance (MDR): an integral approach considering pH and drug resistance in cancer.

Proton pump inhibitors for the treatment of cancer in companion animals (2015)
Journal Article

Placental expression of adenosine A2A receptor and hypoxia inducible factor-1 alpha in early pregnancy, term and pre-eclamptic pregnancies: interactions with placental renin-angiotensin system (2015)
Journal Article

Normal placentation occurs under low oxygen tensions yet hypoxia is also implicated in placental pathologies such as pre-eclampsia (PE). Hypoxia-inducible factors (HIFs), adenosine and tissue renin-angiotensin-system (RAS) are known to promote angiog... Read More about Placental expression of adenosine A2A receptor and hypoxia inducible factor-1 alpha in early pregnancy, term and pre-eclamptic pregnancies: interactions with placental renin-angiotensin system.

Is the atherosclerotic phenotype of pre-eclamptic placentas due to altered lipoprotein concentrations and placental lipoprotein receptors?: role of a small-for-gestational-age phenotype (2013)
Journal Article

Artherosis of spiral arteries in uteroplacental beds from pre-eclamptic women resemble those of atherosclerosis, characterised by increased plasma lipids and lipoproteins. We hypothesised 1) lipoproteins receptors/transporter in placenta would be up-... Read More about Is the atherosclerotic phenotype of pre-eclamptic placentas due to altered lipoprotein concentrations and placental lipoprotein receptors?: role of a small-for-gestational-age phenotype.

Altered placental expression of kisspeptin and its receptor in pre-eclampsia (2012)
Journal Article

Kisspeptin, originally identified as metastatin, important in preventing cancer metastasis, has more recently been shown to be important in pregnancy. Roles indicated for kisspeptin in pregnancy include regulating trophoblast invasion and migration d... Read More about Altered placental expression of kisspeptin and its receptor in pre-eclampsia.

The role of genetics in pre-eclampsia and potential pharmacogenomic interventions (2012)
Journal Article

The pregnancy-specific condition pre-eclampsia not only affects the health of mother and baby during pregnancy but also has long-term consequences, increasing the chances of cardiovascular disease in later life. It is accepted that pre-eclampsia has... Read More about The role of genetics in pre-eclampsia and potential pharmacogenomic interventions.

Folate transporter expression decreases in the human placenta throughout pregnancy and in pre-eclampsia (2012)
Journal Article

The transport of folate across the placenta involves a number of different receptors including folate receptor-alpha (FR-?), reduced folate carrier (RFC) and proton coupled folate transporter (PCFT). In addition there are a number of ATP-dependent tr... Read More about Folate transporter expression decreases in the human placenta throughout pregnancy and in pre-eclampsia.

The importance of antioxidant micronutrients and vitamins in pregnancy (2011)
Journal Article

Pregnancy places increased demands on the mother to provide not only adequate nutrition to support her own health but also to enable the growth and development of the conceptus. A key role of a number of micronutrients and vitamins is their function... Read More about The importance of antioxidant micronutrients and vitamins in pregnancy.

The genetics of pre-eclampsia and other hypertensive disorders of pregnancy (2011)
Journal Article

Hypertension is the most frequent medical complication occurring during pregnancy. In this chapter, we aim to address the genetic contribution to these disorders, with specific focus on preeclampsia. The pathogenic mechanisms underlying pre-eclampsia... Read More about The genetics of pre-eclampsia and other hypertensive disorders of pregnancy.

Possible roles for folic acid in the regulation of trophoblast invasion and placental development in normal early human pregnancy (2011)
Journal Article

In addition to its role in the prevention of neural tube defects, folic acid has many other physiological functions, including cell proliferation, DNA replication, and antioxidant protection. The aim of this study was to determine the role that folic... Read More about Possible roles for folic acid in the regulation of trophoblast invasion and placental development in normal early human pregnancy.