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The genetics of pre-eclampsia and other hypertensive disorders of pregnancy

Williams, Paula J.; Broughton Pipkin, Fiona

Authors

Paula J. Williams

Fiona Broughton Pipkin



Abstract

Hypertension is the most frequent medical complication occurring during pregnancy. In this chapter, we aim to address the genetic contribution to these disorders, with specific focus on preeclampsia. The pathogenic mechanisms underlying pre-eclampsia remain to be elucidated; however, immune maladaptation, inadequate placental development and trophoblast invasion, placental ischaemia, oxidative stress and thrombosis are all thought to represent key factors in the development of disease. Furthermore, all of these components have genetic factors that may be involved in the pathogenic changes occurring. The familial nature of pre-eclampsia has been known for many years and, as such, extensive genetic research has been carried out in this area using strategies that include candidate gene studies and linkage analysis. Interactions between fetal and maternal genotypes, the effect of environmental factors, and epistasis will also be considered.

Journal Article Type Article
Publication Date Aug 1, 2011
Journal Best Practice & Research Clinical Obstetrics and Gynaecology
Electronic ISSN 1521-6934
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 25
Issue 4
APA6 Citation Williams, P. J., & Broughton Pipkin, F. (2011). The genetics of pre-eclampsia and other hypertensive disorders of pregnancy. Best Practice and Research: Clinical Obstetrics and Gynaecology, 25(4), doi:10.1016/j.bpobgyn.2011.02.007
DOI https://doi.org/10.1016/j.bpobgyn.2011.02.007
Keywords pre-eclampsia, genome-wide association study, pregnancy-induced hypertension
Publisher URL http://www.bestpracticeobgyn.com/article/S1521-6934(11)00045-9/abstract
Copyright Statement Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0





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