All Outputs (30)

MRI assessment of cerebral perfusion in clinical trials (2023)
Journal Article

Neurodegenerative mechanisms affect the brain through a variety of processes that are reflected as changes in brain structure and physiology. Although some biomarkers for these changes are well established, others are at different stages of developme... Read More about MRI assessment of cerebral perfusion in clinical trials.

Time-encoded pseudo-continuous arterial spin labeling: Increasing SNR in ASL dynamic angiography (2022)
Journal Article

Purpose: Dynamic angiography using arterial spin labeling (ASL) can provide detailed hemodynamic information. However, the long time-resolved readouts require small flip angles to preserve ASL signal for later timepoints, limiting SNR. By using time-... Read More about Time-encoded pseudo-continuous arterial spin labeling: Increasing SNR in ASL dynamic angiography.

Potential Diagnostic Applications of Multi-Delay Arterial Spin Labeling in Early Alzheimer’s Disease: The Chinese Imaging, Biomarkers, and Lifestyle Study (2022)
Journal Article

Background: Cerebral blood flow (CBF) alterations are involved in the onset and progression of Alzheimer’s disease (AD) and can be a potential biomarker. However, CBF measured by single-delay arterial spin labeling (ASL) for discrimination of mild co... Read More about Potential Diagnostic Applications of Multi-Delay Arterial Spin Labeling in Early Alzheimer’s Disease: The Chinese Imaging, Biomarkers, and Lifestyle Study.

Review and consensus recommendations on clinical APT-weighted imaging approaches at 3T: Application to brain tumors (2022)
Journal Article

Amide proton transfer-weighted (APTw) MR imaging shows promise as a biomarker of brain tumor status. Currently used APTw MRI pulse sequences and protocols vary substantially among different institutes, and there are no agreed-on standards in the imag... Read More about Review and consensus recommendations on clinical APT-weighted imaging approaches at 3T: Application to brain tumors.

Amide proton transfer imaging in stroke (2022)
Journal Article

Amide proton transfer (APT) imaging, a variant of chemical exchange saturation transfer MRI, has shown promise in detecting ischemic tissue acidosis following impaired aerobic metabolism in animal models and in human stroke patients due to the sensit... Read More about Amide proton transfer imaging in stroke.

Quantitative chemical exchange saturation transfer imaging of nuclear overhauser effects in acute ischemic stroke (2022)
Journal Article

Purpose: In chemical exchange saturation transfer imaging, saturation effects between (Formula presented.) 2 to (Formula presented.) 5 ppm (nuclear Overhauser effects, NOEs) have been shown to exhibit contrast in preclinical stroke models. Our previo... Read More about Quantitative chemical exchange saturation transfer imaging of nuclear overhauser effects in acute ischemic stroke.

Validation of the estimation of the macrovascular contribution in multi‐timepoint arterial spin labeling MRI using a 2‐component kinetic model (2021)
Journal Article

Purpose In this paper, the ability to quantify cerebral blood flow by arterial spin labeling (ASL) was studied by investigating the separation of the macrovascular and tissue component using a 2-component model. Underlying assumptions of this model,... Read More about Validation of the estimation of the macrovascular contribution in multi‐timepoint arterial spin labeling MRI using a 2‐component kinetic model.

Partial volume correction in arterial spin labeling perfusion MRI: A method to disentangle anatomy from physiology or an analysis step too far? (2021)
Journal Article

The mismatch in the spatial resolution of Arterial Spin Labeling (ASL) MRI perfusion images and the anatomy of functionally distinct tissues in the brain leads to a partial volume effect (PVE), which in turn confounds the estimation of perfusion into... Read More about Partial volume correction in arterial spin labeling perfusion MRI: A method to disentangle anatomy from physiology or an analysis step too far?.

Examination of optimized protocols for pCASL: Sensitivity to macrovascular contamination, flow dispersion, and prolonged arterial transit time (2021)
Journal Article

Purpose Previously, multi- post-labeling delays (PLD) pseudo-continuous arterial spin labeling (pCASL) protocols have been optimized for the estimation accuracy of the cerebral blood flow (CBF) with/without the arterial transit time (ATT) under a st... Read More about Examination of optimized protocols for pCASL: Sensitivity to macrovascular contamination, flow dispersion, and prolonged arterial transit time.

Study Protocol: The Heart and Brain Study (2021)
Journal Article

Background: It is well-established that what is good for the heart is good for the brain. Vascular factors such as hypertension, diabetes, and high cholesterol, and genetic factors such as the apolipoprotein E4 allele increase the risk of developing... Read More about Study Protocol: The Heart and Brain Study.

Age-related normative changes in cerebral perfusion: data from The Irish Longitudinal Study on Ageing (TILDA) (2021)
Journal Article

Objective To establish normative reference values for total grey matter cerebral blood flow (CBFGM) measured using pseudo-continuous arterial spin labelling (pCASL) MRI in a large cohort of community-dwelling adults aged 54 years and older. Backgroun... Read More about Age-related normative changes in cerebral perfusion: data from The Irish Longitudinal Study on Ageing (TILDA).

Designing and comparing optimized pseudo-continuous Arterial Spin Labeling protocols for measurement of cerebral blood flow (2020)
Journal Article

Arterial Spin Labeling (ASL) is a non-invasive, non-contrast, perfusion imaging technique which is inherently SNR limited. It is, therefore, important to carefully design scan protocols to ensure accurate measurements. Many pseudo-continuous ASL (PCA... Read More about Designing and comparing optimized pseudo-continuous Arterial Spin Labeling protocols for measurement of cerebral blood flow.

Does the magnetization transfer effect bias chemical exchange saturation transfer effects? Quantifying chemical exchange saturation transfer in the presence of magnetization transfer (2020)
Journal Article

Toblerone: Surface-Based Partial Volume Estimation (2019)
Journal Article

Partial volume effects (PVE) present a source of confound for the analysis of functional imaging data. Correction for PVE requires estimates of the partial volumes (PVs) present in an image. These estimates are conventionally obtained via volumetric... Read More about Toblerone: Surface-Based Partial Volume Estimation.

Calibration of arterial spin labeling data—potential pitfalls in post‐processing (2019)
Journal Article

Purpose To assess the impact of the different post?processing options in the calibration of arterial spin labeling (ASL) data on perfusion quantification and its reproducibility. Theory and Methods Absolute quantification of perfusion measuremen... Read More about Calibration of arterial spin labeling data—potential pitfalls in post‐processing.

Quantification of cerebral perfusion and cerebrovascular reserve using Turbo?QUASAR arterial spin labeling MRI (2019)
Journal Article

Purpose To compare cerebral blood flow (CBF) and cerebrovascular reserve (CVR) quantification from Turbo?QUASAR (quantitative signal targeting with alternating radiofrequency labeling of arterial regions) arterial spin labeling (ASL) and single post... Read More about Quantification of cerebral perfusion and cerebrovascular reserve using Turbo?QUASAR arterial spin labeling MRI.

Robust estimation of quantitative perfusion from multi?phase pseudo?continuous arterial spin labeling (2019)
Journal Article

Purpose Multi‐phase PCASL has been proposed as a means to achieve accurate perfusion quantification that is robust to imperfect shim in the labeling plane. However, there exists a bias in the estimation process that is a function of noise in the dat... Read More about Robust estimation of quantitative perfusion from multi?phase pseudo?continuous arterial spin labeling.

ICA-based denoising for ASL perfusion imaging (2019)
Journal Article

Arterial Spin Labelling (ASL) imaging derives a perfusion image by tracing the accumulation of magnetically labeled blood water in the brain. As the image generated has an intrinsically low signal to noise ratio (SNR), multiple measurements are routi... Read More about ICA-based denoising for ASL perfusion imaging.

Association of Midlife Cardiovascular Risk Profiles with Cerebral Perfusion at Older Ages (2019)
Journal Article

© 2019 AMA. All rights reserved. Importance: Poor cardiovascular health is an established risk factor for dementia, but little is known about its association with brain physiology in older adults. Objective: To examine the association of cardiovascul... Read More about Association of Midlife Cardiovascular Risk Profiles with Cerebral Perfusion at Older Ages.

High temporal resolution arterial spin labeling MRI with whole-brain coverage by combining time-encoding with Look-Locker and simultaneous multi-slice imaging (2019)
Journal Article

Purpose The goal of this study was to achieve high temporal resolution, multi?time point pseudo?continuous arterial spin labeling (pCASL) MRI in a time?efficient manner, while maintaining whole?brain coverage. Methods A Hadamard 8?matrix was use... Read More about High temporal resolution arterial spin labeling MRI with whole-brain coverage by combining time-encoding with Look-Locker and simultaneous multi-slice imaging.