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MRI assessment of cerebral perfusion in clinical trials

Wang, Xue; Bishop, Courtney; O'Callaghan, James; Gayhoor, Ali; Albani, Justin; Theriault, Wendy; Chappell, Michael; Golay, Xavier; Wang, Danny; Becerra, Lino

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Xue Wang

Courtney Bishop

James O'Callaghan

Ali Gayhoor

Justin Albani

Wendy Theriault

Xavier Golay

Danny Wang

Lino Becerra


Neurodegenerative mechanisms affect the brain through a variety of processes that are reflected as changes in brain structure and physiology. Although some biomarkers for these changes are well established, others are at different stages of development for use in clinical trials. One of the most challenging biomarkers to harmonize for clinical trials is cerebral blood flow (CBF). There are several magnetic resonance imaging (MRI) methods for quantifying CBF without the use of contrast agents, in particular arterial spin labeling (ASL) perfusion MRI, which has been increasingly applied in clinical trials. In this review, we present ASL MRI techniques, including strategies for implementation across multiple imaging centers, levels of confidence in assessing disease progression and treatment effects, and details of image analysis.


Wang, X., Bishop, C., O'Callaghan, J., Gayhoor, A., Albani, J., Theriault, W., …Becerra, L. (2023). MRI assessment of cerebral perfusion in clinical trials. Drug Discovery Today, 28(4), Article 103506.

Journal Article Type Article
Acceptance Date Jan 10, 2023
Online Publication Date Jan 20, 2023
Publication Date Apr 1, 2023
Deposit Date Jan 26, 2023
Publicly Available Date Jan 27, 2023
Journal Drug Discovery Today
Print ISSN 1359-6446
Electronic ISSN 1878-5832
Publisher Elsevier BV
Peer Reviewed Peer Reviewed
Volume 28
Issue 4
Article Number 103506
Keywords Arterial spin labeling-MRI; cerebral perfusion; clinical trial; multicenter trials
Public URL
Publisher URL


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