MRI assessment of cerebral perfusion in clinical trials

Wang, Xue; Bishop, Courtney; O'Callaghan, James; Gayhoor, Ali; Albani, Justin; Theriault, Wendy; Chappell, Michael; Golay, Xavier; Wang, Danny; Becerra, Lino

doi:10.1016/j.drudis.2023.103506

MRI assessment of cerebral perfusion in clinical trials

Wang, Xue; Bishop, Courtney; O'Callaghan, James; Gayhoor, Ali; Albani, Justin; Theriault, Wendy; Chappell, Michael; Golay, Xavier; Wang, Danny; Becerra, Lino

Authors

Xue Wang

Courtney Bishop

James O'Callaghan

Ali Gayhoor

Justin Albani

Wendy Theriault

Professor MICHAEL CHAPPELL MICHAEL.CHAPPELL@NOTTINGHAM.AC.UK
PROFESSOR OF BIOMEDICAL IMAGING

Xavier Golay

Danny Wang

Lino Becerra

Abstract

Neurodegenerative mechanisms affect the brain through a variety of processes that are reflected as changes in brain structure and physiology. Although some biomarkers for these changes are well established, others are at different stages of development for use in clinical trials. One of the most challenging biomarkers to harmonize for clinical trials is cerebral blood flow (CBF). There are several magnetic resonance imaging (MRI) methods for quantifying CBF without the use of contrast agents, in particular arterial spin labeling (ASL) perfusion MRI, which has been increasingly applied in clinical trials. In this review, we present ASL MRI techniques, including strategies for implementation across multiple imaging centers, levels of confidence in assessing disease progression and treatment effects, and details of image analysis.

Citation

Wang, X., Bishop, C., O'Callaghan, J., Gayhoor, A., Albani, J., Theriault, W., Chappell, M., Golay, X., Wang, D., & Becerra, L. (2023). MRI assessment of cerebral perfusion in clinical trials. Drug Discovery Today, 28(4), Article 103506. https://doi.org/10.1016/j.drudis.2023.103506

Journal Article Type	Article
Acceptance Date	Jan 10, 2023
Online Publication Date	Jan 20, 2023
Publication Date	Apr 1, 2023
Deposit Date	Jan 26, 2023
Publicly Available Date	Jan 27, 2023
Journal	Drug Discovery Today
Print ISSN	1359-6446
Electronic ISSN	1878-5832
Publisher	Elsevier
Peer Reviewed	Peer Reviewed
Volume	28
Issue	4
Article Number	103506
DOI	https://doi.org/10.1016/j.drudis.2023.103506
Keywords	Arterial spin labeling-MRI; cerebral perfusion; clinical trial; multicenter trials
Public URL	https://nottingham-repository.worktribe.com/output/16502614
Publisher URL	https://www.sciencedirect.com/science/article/abs/pii/S1359644623000223?via%3Dihub