MRI assessment of cerebral perfusion in clinical trials

Wang, Xue; Bishop, Courtney; O'Callaghan, James; Gayhoor, Ali; Albani, Justin; Theriault, Wendy; Chappell, Michael; Golay, Xavier; Wang, Danny; Becerra, Lino

Abstract

Neurodegenerative mechanisms affect the brain through a variety of processes that are reflected as changes in brain structure and physiology. Although some biomarkers for these changes are well established, others are at different stages of development for use in clinical trials. One of the most challenging biomarkers to harmonize for clinical trials is cerebral blood flow (CBF). There are several magnetic resonance imaging (MRI) methods for quantifying CBF without the use of contrast agents, in particular arterial spin labeling (ASL) perfusion MRI, which has been increasingly applied in clinical trials. In this review, we present ASL MRI techniques, including strategies for implementation across multiple imaging centers, levels of confidence in assessing disease progression and treatment effects, and details of image analysis.

Citation

Wang, X., Bishop, C., O'Callaghan, J., Gayhoor, A., Albani, J., Theriault, W., …Becerra, L. (2023). MRI assessment of cerebral perfusion in clinical trials. Drug Discovery Today, 28(4), Article 103506. https://doi.org/10.1016/j.drudis.2023.103506

• Journal Article Type: Article
• Acceptance Date: Jan 10, 2023
• Online Publication Date: Jan 20, 2023
• Publication Date: Apr 1, 2023
• Deposit Date: Jan 26, 2023
• Publicly Available Date: Jan 27, 2023
• Journal: Drug Discovery Today
• Print ISSN: 1359-6446
• Electronic ISSN: 1878-5832
• Publisher: Elsevier BV
• Peer Reviewed: Peer Reviewed
• Volume: 28
• Issue: 4
• Article Number: 103506
• DOI: https://doi.org/10.1016/j.drudis.2023.103506
• Keywords: Arterial spin labeling-MRI; cerebral perfusion; clinical trial; multicenter trials
• Public URL: https://nottingham-repository.worktribe.com/output/16502614
• Publisher URL: https://www.sciencedirect.com/science/article/abs/pii/S1359644623000223?via%3Dihub