Review and consensus recommendations on clinical APT-weighted imaging approaches at 3T: Application to brain tumors

Zhou, Jinyuan; Zaiss, Moritz; Knutsson, Linda; Sun, Phillip Zhe; Ahn, Sung Soo; Aime, Silvio; Bachert, Peter; Blakeley, Jaishri O.; Cai, Kejia; Chappell, Michael A.; Chen, Min; Gochberg, Daniel F.; Goerke, Steffen; Heo, Hye Young; Jiang, Shanshan; Jin, Tao; Kim, Seong‐Gi; Laterra, John; Paech, Daniel; Pagel, Mark D.; Park, Ji Eun; Reddy, Ravinder; Sakata, Akihiko; Sartoretti‐Schefer, Sabine; Sherry, A. Dean; Smith, Seth A.; Stanisz, Greg J.; Sundgren, Pia C.; Togao, Osamu; Vandsburger, Moriel; Wen, Zhibo; Wu, Yin; Zhang, Yi; Zhu, Wenzhen; Zu, Zhongliang; Zijl, Peter C. M.

Abstract

Amide proton transfer-weighted (APTw) MR imaging shows promise as a biomarker of brain tumor status. Currently used APTw MRI pulse sequences and protocols vary substantially among different institutes, and there are no agreed-on standards in the imaging community. Therefore, the results acquired from different research centers are difficult to compare, which hampers uniform clinical application and interpretation. This paper reviews current clinical APTw imaging approaches and provides a rationale for optimized APTw brain tumor imaging at 3T, including specific recommendations for pulse sequences, acquisition protocols, and data processing methods. We expect that these consensus recommendations will become the first broadly accepted guidelines for APTw imaging of brain tumors on 3 T MRI systems from different vendors. This will allow more medical centers to use the same or comparable APTw MRI techniques for the detection, characterization, and monitoring of brain tumors, enabling multi-center trials in larger patient cohorts and, ultimately, routine clinical use.

Citation

Zhou, J., Zaiss, M., Knutsson, L., Sun, P. Z., Ahn, S. S., Aime, S., Bachert, P., Blakeley, J. O., Cai, K., Chappell, M. A., Chen, M., Gochberg, D. F., Goerke, S., Heo, H. Y., Jiang, S., Jin, T., Kim, S., Laterra, J., Paech, D., Pagel, M. D., …Zijl, P. C. M. (2022). Review and consensus recommendations on clinical APT-weighted imaging approaches at 3T: Application to brain tumors. Magnetic Resonance in Medicine, 88(2), 546-574. https://doi.org/10.1002/mrm.29241

• Journal Article Type: Article
• Acceptance Date: Mar 2, 2022
• Online Publication Date: Apr 22, 2022
• Publication Date: 2022-08
• Deposit Date: Apr 22, 2022
• Publicly Available Date: Apr 26, 2022
• Journal: Magnetic Resonance in Medicine
• Print ISSN: 0740-3194
• Electronic ISSN: 1522-2594
• Publisher: Wiley
• Peer Reviewed: Peer Reviewed
• Volume: 88
• Issue: 2
• Pages: 546-574
• DOI: https://doi.org/10.1002/mrm.29241
• Keywords: Radiology, Nuclear Medicine and imaging
• Public URL: https://nottingham-repository.worktribe.com/output/7787168
• Publisher URL: https://onlinelibrary.wiley.com/doi/10.1002/mrm.29241