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Quantitative chemical exchange saturation transfer imaging of nuclear overhauser effects in acute ischemic stroke

Msayib, Yunus; Harston, George W.J.; Ray, Kevin J.; Larkin, James R.; Sutherland, Brad A.; Sheerin, Fintan; Blockley, Nicholas P.; Okell, Thomas W.; Jezzard, Peter; Baldwin, Andrew; Sibson, Nicola R.; Kennedy, James; Chappell, Michael A.

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Authors

Yunus Msayib

George W.J. Harston

Kevin J. Ray

James R. Larkin

Brad A. Sutherland

Fintan Sheerin

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NIC BLOCKLEY Nicholas.Blockley@nottingham.ac.uk
Assistant Professor

Thomas W. Okell

Peter Jezzard

Andrew Baldwin

Nicola R. Sibson

James Kennedy



Abstract

Purpose: In chemical exchange saturation transfer imaging, saturation effects between (Formula presented.) 2 to (Formula presented.) 5 ppm (nuclear Overhauser effects, NOEs) have been shown to exhibit contrast in preclinical stroke models. Our previous work on NOEs in human stroke used an analysis model that combined NOEs and semisolid MT; however their combination might feasibly have reduced sensitivity to changes in NOEs. The aim of this study was to explore the information a 4-pool Bloch–McConnell model provides about the NOE contribution in ischemic stroke, contrasting that with an intentionally approximate 3-pool model. Methods: MRI data from 12 patients presenting with ischemic stroke were retrospectively analyzed, as well as from six animals induced with an ischemic lesion. Two Bloch–McConnell models (4 pools, and a 3-pool approximation) were compared for their ability to distinguish pathological tissue in acute stroke. The association of NOEs with pH was also explored, using pH phantoms that mimic the intracellular environment of naïve mouse brain. Results: The 4-pool measure of NOEs exhibited a different association with tissue outcome compared to 3-pool approximation in the ischemic core and in tissue that underwent delayed infarction. In the ischemic core, the 4-pool measure was elevated in patient white matter ((Formula presented.)) and in animals ((Formula presented.)). In the naïve brain pH phantoms, significant positive correlation between the NOE and pH was observed. Conclusion: Associations of NOEs with tissue pathology were found using the 4-pool metric that were not observed using the 3-pool approximation. The 4-pool model more adequately captured in vivo changes in NOEs and revealed trends depending on tissue pathology in stroke.

Journal Article Type Article
Acceptance Date Jan 17, 2022
Online Publication Date Mar 7, 2022
Publication Date 2022-07
Deposit Date Mar 10, 2022
Publicly Available Date Mar 11, 2022
Journal Magnetic Resonance in Medicine
Print ISSN 0740-3194
Electronic ISSN 1522-2594
Publisher Wiley
Peer Reviewed Peer Reviewed
Volume 88
Issue 1
Pages 341-356
DOI https://doi.org/10.1002/mrm.29187
Keywords Radiology, Nuclear Medicine and imaging
Public URL https://nottingham-repository.worktribe.com/output/7570465
Publisher URL https://onlinelibrary.wiley.com/doi/10.1002/mrm.29187

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